Experimental design symbolization and model derivation

A method of design symbolization (DS) is given for a class of designs in which all factors are related by complete crossing or by nesting. Characterization of acceptable DS's, and logical relational properties are given. It is shown how the design model can be obtained from the DS.The preparation of this article was supported by NIH Grant GM-11128, and by grants to the Institute of Human Learning by NSF and NIH.     

The 3RT Test: Three reaction time tasks for IBM PC computers

The 3RT Test consists of a simple, a choice, and a conditional reaction time (RT) task. The three tasks involve comparable visual stimuli and require identical manual responses, but they differ in the complexity of cognitive processing required. The nonverbal stimuli convey commonly known meanings. Responses can be made either on the keyboard or on response keys connected to the computer’s serial port. The computer’s internal timer/counter is used for millisecond timing. The test administration program allows flexible setting of the test conditions. The data analysis program provides summary data not only for each RT task as a whole, but also for separate trial types within each task. Summary statistics include measures of variation and central value that are not affected by extreme scores. In addition to laboratory studies with normal adults, the 3RT Test is suitable for life-span developmental studies, cross-cultural comparisons, and other uses in various clinical settings.     

Potentiation of the pressor response to stress by tolbutamide in dogs

Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α₁-agonist) at 5×10^?6M (which was the EC₅₀ value) was amplified by 2×10^?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents.     

Rules in relevant logic — II: Formula representation

This paper surveys the various forms of Deduction Theorem for a broad range of relevant logics. The logics range from the basic system B of Routley-Meyer through to the system R of relevant implication, and the forms of Deduction Theorem are characterized by the various formula representations of rules that are either unrestricted or restricted in certain ways. The formula representations cover the iterated form,A ₁ .A ₂ . ... .A _n B, the conjunctive form,A ₁&A ₂ & ...A _n B, the combined conjunctive and iterated form, enthymematic version of these three forms, and the classical implicational form,A ₁&A ₂& ...A _n B. The concept of general enthymeme is introduced and the Deduction Theorem is shown to apply for rules essentially derived using Modus Ponens and Adjunction only, with logics containing either (A B)&(B C) .A C orA B .B C .A C.I acknowledge help from anonymous referees for guidance in preparing Part II, and especially for the suggestion that Theorem 9 could be expanded to fully contraction-less logics.