Revisiting the effects of Parkinson's disease and frontal lobe lesions on task switching: The role of rule reconfiguration

This study investigated the hypothesis that rule reconfiguration in task switching can isolate aspects of intact and impaired control at different stages of Parkinson's disease (PD) by comparing switches between concrete naming rules pertaining to stimulus selection, to switches between abstract rules which allocate categorization responses to these stimuli. Based on previous findings, it was hypothesized that attentional switches, where task set competition emerges at the stimulus but not response set level, highlights striatal dopaminergic function. Conversely, increasing the degree of task set competition to encompass reconfiguration of response set when switching between abstract rules, represents a condition which engages the prefrontal cortex (PFC) and renders this manipulation sensitive to frontal damage. To this end, we investigated task switching with concrete and abstract rules in unilaterally (Hoehn & Yahr stage I) and bilaterally (Hoehn & Yahr stage II) affected PD patients, as well as striatally intact frontal lesion patients. As predicted, frontal lesion patients demonstrated switching deficits only with abstract categorization rules, where switching engendered complete task set reconfiguration and a new response, as did stage II PD patients with presumed frontal cortical pathology. Replicating previous findings, stage I PD patients with relatively circumscribed striatal pathology demonstrated no such impairment. Disease severity also impacted on attentional switching indexed by naming rules, since medicated stage II but not stage I patients demonstrated switching deficits emerging from stimulus set reconfiguration, suggesting that the ameliorative efficacy of dopaminergic medication is inversely related to the severity of the striatal deficit. These findings illustrate that the nature of the rules that are switched, and its implication in terms of reconfiguring different task set elements, highlights different neural characters of cognitive flexibility. These manipulations may help decipher the differential effects of progressive neurodegeneration on parkinsonian cognition, and provide a framework in which to conceptualize the contributions of cortical and subcortical regions to cognitive control.     

The influence of discrete emotions on judgement and decision-making: A meta-analytic review

During the past three decades, researchers interested in emotions and cognition have attempted to understand the relationship that affect and emotions have with cognitive outcomes such as judgement and decision-making. Recent research has revealed the importance of examining more discrete emotions, showing that same-valence emotions (e.g., anger and fear) differentially impact judgement and decision-making outcomes. Narrative reviews of the literature (Lerner & Tiedens, 2006 Lerner, J. S. and Tiedens, L. Z. 2006. Portrait of the angry decision maker: How appraisal tendencies shape anger's influence on cognition. Journal of Behavioral Decision-Making, 19: 115–137. [Crossref], [Web of Science ®] , [Google Scholar]; Pham, 2007 Pham, M. T. 2007. Emotion and rationality: A critical review and interpretation of empirical evidence. Review of General Psychology, 11(2): 155–178. [Crossref], [Web of Science ®] , [Google Scholar]) have identified some under-researched topics, but provide a limited synthesis of findings. The purpose of this study was to review the research examining the influence of discrete emotions on judgement and decision-making outcomes and provide an assessment of the observed effects using a meta-analytic approach. Results, overall, show that discrete emotions have moderate to large effects on judgement and decision-making outcomes. However, moderator analyses revealed differential effects for study-design characteristics and emotion-manipulation characteristics by emotion type. Implications are discussed.     

Strangers at the benchside: research ethics consultation

Institutional ethics consultation services for biomedical scientists have begun to proliferate, especially for clinical researchers. We discuss several models of ethics consultation and describe a team-based approach used at Stanford University in the context of these models. As research ethics consultation services expand, there are many unresolved questions that need to be addressed, including what the scope, composition, and purpose of such services should be, whether core competencies for consultants can and should be defined, and how conflicts of interest should be mitigated. We make preliminary recommendations for the structure and process of research ethics consultation, based on our initial experiences in a pilot program.     

What’s the point? Domestic dogs’ sensitivity to the accuracy of human informants

Animal Cognition - Dogs excel at understanding human social-communicative gestures like points and can distinguish between human informants who vary in characteristics such as knowledge or...     

A Model of Sexually and Physically Victimized Women’s Process of Attaining Effective Formal Help over Time: The Role of Social Location, Context, and Intervention

As empirical evidence has demonstrated the pervasiveness of sexual assault and intimate partner violence in the lives of women, and the links to poor mental health outcomes, attention has turned to examining how women seek and access formal help. We present a conceptual model that addresses prior limitations and makes three key contributions: It foregrounds the influence of social location and multiple contextual factors; emphasizes the importance of the attainment of effective formal help that meets women's needs and leads to positive mental health outcomes; and highlights the role of interventions in facilitating help attainment. We conclude with research and practice implications.     

When do children trust the expert? Benevolence information influences children's trust more than expertise

How do children use informant niceness, meanness, and expertise when choosing between informant claims and crediting informants with knowledge? In Experiment 1, preschoolers met two experts providing conflicting claims for which only one had relevant expertise. Five‐year‐olds endorsed the relevant expert's claim and credited him with knowledge more often than 3‐year‐olds. In Experiment 2, niceness/meanness information was added. Although children most strongly preferred the nice relevant expert, the children often chose the nice irrelevant expert when the relevant one was mean. In Experiment 3, a mean expert was paired with a nice non‐expert. Although this nice informant had no expertise, preschoolers continued to endorse his claims and credit him with knowledge. Also noteworthy, children in all three experiments seemed to struggle more to choose the relevant expert's claim than to credit him with knowledge. Together, these experiments demonstrate that niceness/meanness information can powerfully influence how children evaluate informants.     

Quality of Life among Caregivers of children with Autism Spectrum Disorders,Intellectual Disability,and Typical Development

Applied Research in Quality of Life - The quality of life (QoL) of the caregivers of children with autism spectrum disorder and intellectual disabilities has received limited attention in emerging...     

The influence of discrete emotions on judgement and decision-making: a meta-analytic review

During the past three decades, researchers interested in emotions and cognition have attempted to understand the relationship that affect and emotions have with cognitive outcomes such as judgement and decision-making. Recent research has revealed the importance of examining more discrete emotions, showing that same-valence emotions (e.g., anger and fear) differentially impact judgement and decision-making outcomes. Narrative reviews of the literature (Lerner & Tiedens, 2006 ; Pham, 2007 ) have identified some under-researched topics, but provide a limited synthesis of findings. The purpose of this study was to review the research examining the influence of discrete emotions on judgement and decision-making outcomes and provide an assessment of the observed effects using a meta-analytic approach. Results, overall, show that discrete emotions have moderate to large effects on judgement and decision-making outcomes. However, moderator analyses revealed differential effects for study-design characteristics and emotion-manipulation characteristics by emotion type. Implications are discussed.