伤害回避的脑机制及其生物基础

伤害回避是指个体对厌恶刺激信号做出强烈的反应,并学会被动地回避惩罚的一种倾向,这一倾向使得个体反复思考未来的结局,并谨慎小心地对待不确定情景中的事件,进而更有可能诱发情感障碍。伤害回避涉及的神经网络包括三个子网络,即额顶叶-前扣带皮层的连接、皮层-杏仁核的连接和白质通道的结构性连接,这三个子网络分别与羞怯感-易疲劳性、预期担心以及不确定环境中的害怕情绪有关。而其生物基础则包括单一基因多态性和基因多态间的交互作用。今后的研究应该集中在深化伤害回避神经网络与生物基础间的联合机制、研究三种及以上基因多态间的交互作用、考察其他因素对基因效应的调节作用、注重伤害回避四种亚型相关神经网络之间的连接、探讨5-HT4等其他几种5-羟色胺受体多态性与伤害回避的关系以及分析伤害回避内部机制在抗抑郁治疗中的作用等方面。     

康德论纯粹实践理性的动机

纯粹实践理性动机的理论是康德道德哲学中的重要环节,但并未得到足够重视与研究。定言命令的奠基意义不仅局限于规范伦理学,也为解决德性动力学问题提供了基础;德性法则作为意志的规定根据,对感性产生作用,使人在德性法则面前感到谦卑,因而对德性法则产生敬重;敬重作为"能被先天认识的并看出其必然性的唯一情感",是德性唯一纯粹的动机;敬重概念还确立了人所能够达到的德性层次——出于对义务的敬重而行动。     

We should screen for major depression

This article is a response to Coyne, Thompson, Palmer, Kagee, and Maunsell's (2000) article, “Should We Screen for Depression? Caveats and Potential Pitfalls.” We address four points that we view as central to their argument: (1) current screening measures are inadequate; (2) correct identification of depressed patients does not result in improved clinical outcomes; (3) screening is too expensive; and (4) screening may have harmful negative effects. We discuss the following important issues: (1) screening and prevention are still in the research and development phase; (2) the kindling phenomenon is an important reason to screen; (3) there is a need to focus screening and prevention efforts on ethnic minorities; and (4) high depressive symptoms have a substantial public health impact. Finally, we present reasons why screening is advisable, both for prevention and treatment purposes, and provide our recommendations. Our stance is that, in order for screening and prevention to become practical, they need to be implemented in both research and practice contexts. Therefore, we should make screening for major depression a priority.     

Parents' structuring of children's daily lives in relation to the quality and stability of children's friendships

This study focused on the implications of parents' structuring of their children's home lives for the friendships of their children. Participants were 224 elementary‐school children (108 girls and 116 boys) from four grade levels in two schools in Aix‐en‐Provence, France. Most of the families were of middle or high socio‐economic status. The participating children were seen twice during the same school year in order to assess the stability of their friendship choices and the quality of their friendships. We used Lautrey's (1989) questionnaire in order to assess the parents' styles in the structuring of family life and related child‐rearing practice. This questionnaire delineates three structuring styles: 1) rigid, characterized by considerable imposition of routines with little leeway for exceptional circumstances; 2) flexible, in which established routines can be modified as circumstances dictate; and 3) laissez‐faire, characterized by an absence of predictability and routine. We measured friendship quality by means of Friendship Quality Scale developed by Bukowski, Hoza, and Boivin (1989). This scale consists of 23 items representing five dimensions: companionship, help, security, closeness and conflict. This tool was designed to elicit children's perceptions of a specific relationship with a friend. Results indicated a significant link between parenting style and both of the dimensions of child friendship we studied. Children from homes characterized by a laissez‐faire style of parenting have friendships with more positive features than children from homes with flexible or rigid styles. We also found that friendships were generally less stable and rated as less positive than in similar studies conducted in other countries.     

Learned associability and associative change in human causal learning.

The Mackintosh (1975) model of associative learning specifies that processing of both the cues presented on a trial and the outcome of that trial will interact to determine the amount of associative change undergone by a given cue. Experiments looking at the distribution of associative change among the elements of a reinforced compound in animal conditioning studies indicate that processing of the outcome of a trial does indeed influence associative change. The work reported here investigates the distribution of associative change among the elements of a reinforced compound in a human causal judgement paradigm, and it indicates that processing of the cues presented on a trial also plays a role in determining associative change (in terms of changes in the associability of cues as a result of experience). Taken in combination, these results provide good support for Mackintosh (1975) and the characterizations of both cue and outcome processing that it offers.     

A methodological study in a space flight simulation context]

To study the effects of isolation and confinement on small groups during long space flights, it is habitual to use closed hyperbaric ground chambers. For the first time, the European Space Agency made use of a nautral environment taking advantage of an Antarctic winter-over at the French Dumont d'Urville Station. The main objective of that study ("International Antarctic Psychological Programme"), was to compare different Russian tests used for training cosmonauts to a W. European approach validated during previous winter studies and European ground chamber simulations. Russian techniques appeared to be oriented to a narrow range of phenomena and unsuited to discern the adjustment to stress conditions.     

Definiteness and voice in the interpretation of active and passive sentences

In Experiment I, subjects were given active and passive sentences where the definiteness of nominals is varied and about which uncertainty was expressed, e.g. “I thought that the policeman had been injured by a gangster, but I was mistaken, in fact.”. Their task was to decide what was the target of the mistake by completing freely the sentence in such a way that the account would be corrected. When the nominals are differentially determined (a-the, the-a), the pattern of responses indicates that, for both active and passive, subjects were more likely to conclude that it was the non-definitely marked nominal that had been involved in the mistake rather than the definitely marked one. When both nominals are similarly determined (a-a, the-the), subjects were more likely to indicate the event itself as having been involved in the mistake. This supports the hypothesis that subjects are able to utilize definiteness to determine the relation between presupposed and assertional information. In Experiment II, subjects were given paired active and passive sentences with differentially determined nominals and were required to choose between the two syntactic forms of each pair the one they would prefer to use. The pattern of responses clearly shows that subjects were more likely to choose the voice allowing the hypothesized preferential order “Definitely marked grammatical subject-non-definitely marked grammatical object”. Passive transformational rule is thus interpreted as a particular case of a more general rule specifying the ways in which what is made known (comment) is nested on to what is already assumed to be the case (topic).