尼可地尔与前列地尔预处理对大鼠心肌缺血再灌注的影响

研究尼可地尔、前列地尔及两药物联合应用预处理对心肌缺血再灌注中的影响,探究其作用机制.采用Tunel法检测心肌组织的凋亡情况,免疫组化法检测Bax、Bcl-2和caspase-3的蛋白表达情况.结果显示尼可地尔和前列地尔半剂量联合组细胞凋亡数、Bax和caspase-3的表达量均明显低于其他给药组(P＜0.05),Bcl-2的表达量明显高于其他给药组(P＜0.05);尼可地尔和前列地尔单给药组细胞凋亡、Bax、caspase-3表达均有降低,Bcl-2表达升高,但效果不及联合用药半剂量组.以此得出结论尼可地尔和前列地尔的联合用药效果较好,可加强对心肌的保护作用.     

Atomangst

Utilizing complex statistical analyses, namely latent growth modeling, the long-term development of worries among peace movement supporters is examined. Data originate from a 7-wave German longitudinal study started in 1985 with the then on average 14-year-old subjects. Waves were interspersed at 3? year intervals. Activists are assumed to have lower (self-related) microworries (H1) and higher macroworries (concerned with larger entities; H2) than non-activists at the onset of the study. Non-activists who appraised the threat of nuclear war as high in 1985 are assumed to report worse mental health than their activist age mates 21 years later (H3). Activists are assumed to express relatively more macroworries than non-activists in mid-adulthood (H4). All four hypotheses were confirmed. Results are interpreted as evidence for the psychoanalytic argumentation by Leith?user that fear of global threats is likely to be displaced into personal anxiety if not coped with in the form of ??identifying participation?? in political action, suggesting that refraining from acting out against a perceived sociopolitical threat is a long-term risk for a positive mental-health trajectory.     

Suicidal Ideation and Sexual Orientation in College Students: The Roles of Perceived Burdensomeness,Thwarted Belongingness,and Perceived Rejection Due to Sexual Orientation

A theoretical model in which perceived burdensomeness and thwarted belongingness were hypothesized to account for the association between sexual orientation and suicidal ideation among college students was tested. Among 198 college students (mean age 21.28 years), gay, lesbian, and bisexual students (n = 50) reported significantly higher levels of perceived burdensomeness and suicidal ideation than heterosexual students. The relationship between sexual orientation and suicidal ideation was partially accounted for by perceived burdensomeness, but not thwarted belongingness. This indirect effect was stronger at higher levels of perceived or anticipated rejection due to one’s sexual orientation. Implications for intervention and prevention science are discussed.     

Cyborgs, uploading and immortality — Some serious concerns

Transhumanism and Extropianism are two recent ‘movements’ which aspire to transcend the perceived limitations of human biological evolution. This paper takes a critical look at two of the most controversial aspects of Extropianism—Uploading and Immortality. Uploading is the process by which a human will be able to transfer the entire contents of their brain to a more suitable supercomputational medium. When the newentity exist as software, immortality is virtually assured. This should be possible, it is claimed, within the next fifty years! From both a pragmatic and philosophical perspective, I argue that these claims are at best misguided and at worst absurd.