Evaluating clinical significance: Incorporating robust statistics with normative comparison tests

The purpose of this study was to evaluate a modified test of equivalence for conducting normative comparisons when distribution shapes are non‐normal and variances are unequal. A Monte Carlo study was used to compare the empirical Type I error rates and power of the proposed Schuirmann–Yuen test of equivalence, which utilizes trimmed means, with that of the previously recommended Schuirmann and Schuirmann–Welch tests of equivalence when the assumptions of normality and variance homogeneity are satisfied, as well as when they are not satisfied. The empirical Type I error rates of the Schuirmann–Yuen were much closer to the nominal α level than those of the Schuirmann or Schuirmann–Welch tests, and the power of the Schuirmann–Yuen was substantially greater than that of the Schuirmann or Schuirmann–Welch tests when distributions were skewed or outliers were present. The Schuirmann–Yuen test is recommended for assessing clinical significance with normative comparisons.     

Saccadic output is influenced by limb kinetics during eye-hand coordination

In several recent studies, saccadic eye movements were found to be influenced by concurrent reaching movements. The authors investigated whether that influence originates in limb kinematic or kinetic signals. To dissociate those 2 possibilities, the authors required participants (N = 6) to generate pointing movements with a mass that either resisted or assisted limb motion. With practice, participants were able to generate pointing responses with very similar kinematics but whose kinetics varied in a systematic manner. The results showed that saccadic output was altered by the amount of force required to move the arm, consistent with an influence from limb kinetic signals. Because the interaction occurred before the pointing response began, the authors conclude that a predictive signal related to limb kinetics modulates saccadic output during tasks requiring eye-hand coordination.     

Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning

Convergent evidence highlights the differential contributions of various regions of the prefrontal cortex in the service of cognitive control, but little is understood about how the brain determines and communicates the need to recruit cognitive control, and how such signals instigate the implementation of appropriate performance adjustments. Here we review recent progress from cognitive neuroscience in examining some of the main constituent processes of cognitive control as involved in dynamic decision making: goal-directed action selection, response activation and inhibition, performance monitoring, and reward-based learning. Medial frontal cortex is found to be involved in performance monitoring: evaluating outcome vis-a-vis expectancy, and detecting performance errors or conflicting response tendencies. Lateral and orbitofrontal divisions of prefrontal cortex are involved in subsequently implementing appropriate adjustments.     

Backward-compatibility effects with irrelevant stimulus-response overlap: the case of the SNARC effect

In 3 dual-task experiments, the relationship between primary-task response (R1) and secondary-task response (R2) was varied. In general, R1-left responses were faster when followed by the word one, and right responses were faster when followed by the word two. This backward-compatibility (BWC) effect indicated (a) that activation of R2 was not delayed until R1 selection was completed, and (b) that activation of the vocal responses was accompanied by the automatic activation of magnitude codes, known to be associated with spatial left-right codes (spatial-numerical association of response codes [the SNARC effect]). These findings supported the hypotheses (a) that BWC effects persist even with irrelevant R1-R2 overlap, (b) that the SNARC effect is based on associations between magnitude and spatial representations underlying response processing, and (c) that the production and perception of magnitudes relies on common codes.     

Mass perturbation of a body segment: 1. Effects on segment dynamics

Investigators often use mass perturbation of body segments as an experimental paradigm to study movement coordination. To analyze the effect of mass perturbation on small-amplitude oscillations, the authors linearize the equation of motion of a single segment moving in a vertical plane and derive the effect of added mass on the undamped eigenfrequency, the relative damping, and the low-frequency control gain of the segment. Mass addition results in a decrease in both the relative damping and the low-frequency control gain; the undamped eigenfrequency increases for mass addition between the pivot point and R0 (where R0 is the length of a point mass pendulum whose undamped eigenfrequency is identical to that of the unperturbed segment), decreases for mass addition beyond R0, and remains unaffected for mass addition at R0. For a typical lower leg + foot segment, R0 is just proximal to the ankle joint. That location may explain the absence of an effect on oscillation frequency in studies in which mass has been added to the ankle. The authors' analysis provides a basis for a more effective application of mass perturbations in future experiments.     

State-dependent and odor-mediated anemotactic responses of a micro-arthropod on a novel type of locomotion compensator

A novel type of locomotion compensator was designed and tested for its use in orientation behavior experiments with a predatory mite. In this apparatus, displacements of the test animal in the two-dimensional plane are recorded using video equipment and a servosphere that keeps the animal in focus. Thex andy displacements are registeredusing two rotation encoders and are compensated using a pair of servo-motors, in such a way that the animal is always positioned on top of the sphere, yet moves freely. Well-fed and starved predators were tested for their responses to (1) still air, (2) a stimulus-free air flow, (3) an air flow with odors from uninfested Lima bean leaves, and (4) an air flow with odors from Lima bean leaves infested by plant-feeding mites, the prey of the predatory mites. Anemotactic responses of adultPhytoseivlus persimilis females were feeding state dependent. Well-fed predators moved downwind under Treatments 1–3 but moved neither up-nor downwind in the presence of odors from infested plants (Treatment 4). Starved predators moved upwind under all treatments. These results are in agreement with those of earlier studies in a wind tunnel, and therefore, the new type of locomotion compensator (LC-100) offers an excellent method for studying the orientation behavior of micro-arthropods.     

Mass perturbation of a body segment: 2. Effects on interlimb coordination

The shifts in relative phase that are observed when rhythmically coordinated limbs are submitted to asymmetric mass perturbations have typically been attributed to the induced eigenfrequency difference (delta omega) between limbs. Modeling the moving limbs as forced linear oscillators, however, reveals that asymmetric mass perturbations may induce a difference not only in eigenfrequency (i.e., delta omega not equal 0) but also in the covarying low-frequency control gains (i.e., delta k not equal 0). Because the inverse of the low-frequency control gain (k) reflects the level of muscular torque (input) required for a particular displacement from equilibrium (output), asymmetric mass perturbations may result in an imbalance in the muscular torques required for task performance (related to delta k not equal 0). Thus, it is possible that the effects attributed to delta omega were in fact mediated by delta k. In 2 experiments, the authors manipulated delta k and delta omega separately by applying mass perturbations to the lower legs of 9 participants. The relative phasing between the legs was not affected by delta k, but manipulation of delta omega (while delta k remained approximately 0) induced systematic relative phase shifts that were more pronounced for antiphase than for in-phase coordination. That indication that the coordination dynamics is indeed influenced by an imbalance in eigenfrequency is discussed vis-a-vis the question of how such a merely peripheral property may affect the underlying coordination process.     

Shape-from-shading depends on visual, gravitational, and body-orientation cues

The perception of shading-defined form results from an interaction between shading cues and the frames of reference within which those cues are interpreted. In the absence of a clear source of illumination, the definition of 'up' becomes critical to deducing the perceived shape from a particular pattern of shading. In our experiments, twelve subjects adjusted the orientation of a planar disc painted with a linear luminance gradient from one side to the other, until the disc appeared maximally convex-that is, until the luminance gradient induced the maximum perception of a three-dimensional shape. The vision, gravity, and body-orientation cues were altered relative to each other. Visual cues were manipulated by the York Tilted Room facility, and body cues were altered by simply lying on one side. The orientation of the disc that appeared maximally convex varied in a systematic fashion with these manipulations. We present a model in which the direction of perceptual 'up' is determined from the sum of three weighted vectors corresponding to the vision, gravity, and body-orientation cues. The model predicts the perceived direction of 'up', contributes to our understanding of how shape-from-shading is deduced, and also predicts the confidence with which the 'up' direction is perceived.