Evidence of Non-Linear Associations between Frustration-Related Prefrontal Cortex Activation and the Normal:Abnormal Spectrum of Irritability in Young Children

Burgeoning interest in early childhood irritability has recently turned toward neuroimaging techniques to better understand normal versus abnormal irritability using dimensional methods. Current accounts largely assume a linear relationship between poor frustration management, an expression of irritability, and its underlying neural circuitry. However, the relationship between these constructs may not be linear (i.e., operate differently at varying points across the irritability spectrum), with implications for how early atypical irritability is identified and treated. Our goal was to examine how the association between frustration-related lateral prefrontal cortex (LPFC) activation and irritability differs across the dimensional spectrum of irritability by testing for non-linear associations. Children (N = 92; ages 3–7) ranging from virtually no irritability to the upper end of the clinical range completed a frustration induction task while we recorded LPFC hemoglobin levels using fNIRS. Children self-rated their emotions during the task and parents rated their child’s level of irritability. Whereas a linear model showed no relationship between frustration-related LPFC activation and irritability, a quadratic model revealed frustration-related LPFC activation increased as parent-reported irritability scores increased within the normative range of irritability but decreased with increasing irritability in the severe range, with an apex at the 91st percentile. Complementarily, we found children’s self-ratings of emotion during frustration related to concurrent LPFC activation as an inverted U function, such that children who reported mild distress had greater activation than peers reporting no or high distress. Results suggest children with relatively higher irritability who are unimpaired may possess well-developed LPFC support, a mechanism that drops out in the severe end of the irritability dimension. Findings suggest novel avenues for understanding the heterogeneity of early irritability and its clinical sequelae.     

Applied Problem Solving in Children with ADHD: The Mediating Roles of Working Memory and Mathematical Calculation

The difficulties children with ADHD experience solving applied math problems are well documented; however, the independent and/or interactive contributions of cognitive processes underlying these difficulties are not fully understood and warrant scrutiny. The current study examines two primary cognitive processes integral to children’s ability to solve applied math problems: working memory (WM) and math calculation skills (i.e., the ability to utilize specific facts, skills, or processes related to basic math operations stored in long-term memory). Thirty-six boys with ADHD-combined presentation and 33 typically developing (TD) boys aged 8–12 years old were administered multiple counterbalanced tasks to assess upper (central executive [CE]) and lower level (phonological [PH STM] and visuospatial [VS STM] short-term memory) WM processes, and standardized measures of mathematical abilities. Bias-corrected, bootstrapped mediation analyses revealed that CE ability fully mediated between-group differences in applied problem solving whereas math calculation ability partially mediated the relation. Neither PH STM nor VS STM was a significant mediator. When modeled together via serial mediation analysis, CE in tandem with math calculation ability fully mediated the relation, explained 79% of the variance, and provided a more parsimonious explication of applied mathematical problem solving differences among children with ADHD. Results suggest that interventions designed to address applied math difficulties in children with ADHD will likely benefit from targeting basic knowledge of math facts and skills while simultaneously promoting the active interplay of these skills with CE processes.     

The Behavioral Approach System (BAS) Model of Vulnerability to Bipolar Disorder: Evidence of a Continuum in BAS Sensitivity across Adolescence

Behavioral Approach System (BAS) sensitivity has been implicated in the development of a variety of different psychiatric disorders. Prominent among these in the empirical literature are bipolar spectrum disorders (BSDs). Given that adolescence represents a critical developmental stage of risk for the onset of BSDs, it is important to clarify the latent structure of BAS sensitivity in this period of development. A statistical approach especially well-suited for delineating the latent structure of BAS sensitivity is taxometric analysis, which is designed to evaluate whether the latent structure of a construct is taxonic (i.e., categorical) or dimensional (i.e., continuous) in nature. The current study applied three mathematically non-redundant taxometric procedures (i.e., MAMBAC, MAXEIG, and L-Mode) to a large community sample of adolescents (n = 12,494) who completed two separate measures of BAS sensitivity: the BIS/BAS Scales Carver and White (Journal of Personality and Social Psychology, 67, 319–333. 1994) and the Sensitivity to Reward and Sensitivity to Punishment Questionnaire (Torrubia et al. Personality and Individual Differences, 31, 837–862. 2001). Given the significant developmental changes in reward sensitivity that occur across adolescence, the current investigation aimed to provide a fine-grained evaluation of the data by performing taxometric analyses at an age-by-age level (14–19 years; n for each age ≥ 883). Results derived from taxometric procedures, across all ages tested, were highly consistent, providing strong evidence that BAS sensitivity is best conceptualized as dimensional in nature. Thus, the findings suggest that BAS-related vulnerability to BSDs exists along a continuum of severity, with no natural cut-point qualitatively differentiating high- and low-risk adolescents. Clinical and research implications for the assessment of BSD-related vulnerability are discussed.     

Pina Bausch and the Interweaving of Trauma,Memory, and Creative Transformation: Commentary on Papers by Sarah Mendelsohn and Deborah Dowd

In her “dance-theater” (Tanztheater), Pina Bausch famously instructed her dancers with almost no language, encouraging her dancers to feel their way into the dance, to get in touch with their deepest vulnerabilities. In their papers, Sarah Mendelsohn and Deborah Dowd share with us, their audience, ways in which they, too, struggled to get in touch with their most vulnerable selves. Caught in an unending present with their challenging, traumatized patients, their struggle to locate themselves, and their own vulnerabilities in their patients, to experience the shame of their own childhood trauma, allowed for enlivened creative movement and profound psychic change.     

Math Intervention For Latino Parents and Kindergarteners Based on Food Routines

Family food routines are important contexts through which children develop math knowledge and skills. The Food For Thought (FFT) program teaches Latino parents strategies to develop their kindergarten children's math abilities during family food routines such as grocery shopping and cooking. We examined whether attendance to FFT was related to children's math outcomes at post-test (right after program completion). Sixty-eight low-income Latino parents and their kindergarten children (M?=?71 months) participated in the four-week program taking place in schools. Children's math skills (counting, numeral recognition and cardinal understanding) were assessed at pre- and post-test. The association between parents' attendance to FFT meetings and children′s math outcomes at post-test depended on children's initial levels of math skills (i.e., math skills at pre-test). Children with lower initial math skills whose parents attended more FFT meetings had more advanced math outcomes at post-test, than children with lower initial math skills whose parents attended fewer FFT meetings. The effect size of this interaction was moderate, d?=?0.46. Limitations and future directions of this early math intervention targeting Latino families are discussed.     

Recalled Challenging Parenting Behavior and Anxiety in Adulthood: An Exploratory Retrospective Cohort Study

This research examined the relationship between recalled challenging parenting behavior (CPB) and adult anxiety and aimed to determine the underlying latent factors involved in CPB. CPB is a novel parenting construct that involves the encouragement of children to go beyond their own limits and engage with concepts they may find scary or that destabilises them, in a playful and fun way. Participants in the current study were 386 undergraduate psychology students (M age?=?19.89 years, SD?=?4.6; range 17–56). Questionnaire measures of CPB, anxiety, and social anxiety were delivered to participants via an online survey. An exploratory factor analysis was conducted using Principle Axis Factoring with Oblimin rotation. This identified three latent constructs underlying adults recall of CPB during childhood; parental encouragement of social assertion (‘Social’), parental encouragement to engage in novel or new situations (‘Novelty’), and intentional teasing (‘Teasing’) CPB. Both mother and father Social and Novelty CPB was associated with lower report of adult anxiety. However, only fathers Teasing was able to predict adult anxiety.     

Self-compassion induction enhances recovery from social stressors: Comparing adults with social anxiety disorder and healthy controls

Background and objectives: This study evaluates the process and consequence of inducing self-compassion during recovery from social performance stressors. Though interest in self-compassion as an intervention target is growing, extant findings suggest that initially cultivating self-compassion can be challenging for those with high self-criticism and anxiety, common features of social anxiety disorder (SAD).

Design: Quasi-experimental design.

Methods: The current study evaluates the feasibility, content, and outcomes of a brief written self-compassion induction administered after consecutive laboratory social stressors, among adults with SAD (n?=?21) relative to healthy controls (HC; n?=?35).

Results: Findings demonstrate the feasibility of employing a written self-compassion induction among adults with (and without) SAD, reveal group differences in written responses to the induction, and suggest that the SAD group benefitted more from the induction than the HC group, based on greater reductions in state anxiety and greater increases in self-compassion during stressor recovery. Greater use of negative affect words within written responses to the self-compassion induction, but not during general writing, predicted lower subsequent state anxiety across groups, by a medium effect size.

Conclusions: Collectively, the findings support the feasibility and utility of cultivating self-compassion among adults with SAD.     

Transition to success on the model room task: the importance of improvements in working memory

Previous work has shown that children under age 3 often perform very poorly on the model room task, in which they are asked to find a hidden toy based on its location in a scale model. One prominent theory for their failure is that they lack the ability to understand the model as both a physical object and as a symbolic representation of the larger room. A hypothesized additional component is that they need to overcome weak, competing representations of where the object was on a previous trial, and where it is in the present trial, in order to succeed in their search. Children aged 33–39 months were tested on the model room task, as well as on measures of cognitive inhibitory control, cognitive flexibility, and working memory. Results showed that performance on the model room task was not predicted by measures of inhibitory control or cognitive flexibility, but was predicted by performance on the Delayed Recognition Span Test (DRST), a measure of working memory. These findings lend support to the theory of competing representations and demonstrate the necessity of updating and maintaining strong representations in working memory to succeed in the search task.     

A longitudinal analysis of the relationship between self-compassion and the psychological effects of perceived stress

ABSTRACT

Self-compassion is consistently associated with psychological well-being, but most research has examined their relationship at only a single point in time. This study employed a longitudinal design to investigate the relationship between baseline self-compassion, perceived stress, and psychological outcomes in college students (n = 462) when the outcomes were measured both concurrently with perceived stress and after a lag of six months. Self-compassion moderated the effects of perceived stress such that stress was less strongly related to depression, anxiety, and negative affect among participants who scored high rather than low in self-compassion. Self-compassion also moderated the effects of perceived stress on depression and anxiety prospectively after six months. Self-compassion predicted positive affect but moderated the effects of perceived stress on positive affect in only one analysis. This study suggests that high self-compassion provides emotional benefits over time, partly by weakening the link between stress and negative outcomes.     

Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes

This paper highlights a symposium on stress risk factors and stress susceptibility, presented at the Neurobiology of Stress workshop in Boulder, CO, in June 2010. This symposium addressed factors linking stress plasticity and reactivity to stress pathology in animal models and in humans. Dr. J. Radley discussed studies demonstrating prefrontal cortical neuroplasticity and prefrontal control of hypothalamo-pituitary-adrenocortical axis function in rats, highlighting the emerging evidence of the critical role that this region plays in normal and pathological stress integration. Dr. M. Kabbaj summarized his studies of possible epigenetic mechanisms underlying behavioral differences in rat populations bred for differential stress reactivity. Dr. L. Jacobson described studies using a mouse model to explore the diverse actions of antidepressants in brain, suggesting mechanisms whereby antidepressants may be differentially effective in treating specific depression endophenotypes. Dr. R. Yehuda discussed the role of glucocorticoids in post-traumatic stress disorder (PTSD), indicating that low cortisol level may be a trait that predisposes the individual to development of the disorder. Furthermore, she presented evidence indicating that traumatic events can have transgenerational impact on cortisol reactivity and development of PTSD symptoms. Together, the symposium highlighted emerging themes regarding the role of brain reorganization, individual differences, and epigenetics in determining stress plasticity and pathology.