Terminal decline and cognitive performance in very old age: does cause of death matter?

Cross-sectional differences and longitudinal changes in cognitive functioning in relation to mortality across a 7-year follow-up period, with 3 times of measurement, were examined in a population-based sample of very old adults. The authors also sought to determine whether cause of death (cerebro/cardiovascular disease [CVD]; non-CVD) modified the magnitude of mortality-related cognitive deficits. Cognitive performance was indexed by tests of general cognitive ability, episodic memory, primary memory, verbal fluency, and visuospatial ability. Results indicated cross-sectional differences on all domains of functioning, with persons who would die within 3 years after baseline testing performing more poorly. Longitudinally, greater decrements were observed on all domains for persons who would die after the first follow-up period, as compared with survivors. Cause of death failed to modify the magnitude of the cross-sectional and longitudinal deficits. The pattern of results point to the general nature of this phenomenon.     

Constructing a short form of the Smoking Consequences Questionnaire with adolescents and young adults

The goal of the present studies was to construct and validate a short form of the 50-item Smoking Consequences Questionnaire (SCQ; T.H. Brandon & T. B. Baker, 1991), a measure of smoking outcome expectancies. In Study 1, a 21-item short form (S-SCQ) was derived from a sample of 107 young adults previously treated for substance abuse. In Study 2, the measure was cross-validated on 125 adolescents in treatment for substance abuse. Confirmatory factor analyses revealed good model fit and factorial invariance for the 4 S-SCQ subscales across both samples. Validation analyses on each sample found that subscale scores generally correlated significantly with smoking-related variables. The present studies provide initial evidence for the utility of the S-SCQ when used with young adults and adolescents.     

Beyond the five-user assumption: Benefits of increased sample sizes in usability testing

It is widely assumed that 5 participants suffice for usability testing. In this study, 60 users were tested and random sets of 5 or more were sampled from the whole, to demonstrate the risks of using only 5 participants and the benefits of using more. Some of the randomly selected sets of 5 participants found 99% of the problems; other sets found only 55%. With 10 users, the lowest percentage of problems revealed by any one set was increased to 80%, and with 20 users, to 95%.     

Effects of LY354740, a novel glutamatergic metabotropic agonist, on nonhuman primate hypothalamic-pituitary-adrenal axis and noradrenergic function

The search for novel anxiolytics and antidepressants has focused on compounds with the potential to reduce excessive hypothalamic-pituitary-adrenal (HPA) axis activity. L-glutamate, an excitatory neurotransmitter ubiquitously present within the central nervous system, conceivably plays an important role in activating the neural sites involved in stress modulation. Deactivation of the HPA axis by glutamatergic neurotransmission modulation may represent a novel therapeutic approach. Accordingly, the acute intravenous effects of the novel metabotropic (mGlu2/3) agonist LY354740 were tested on bonnet macaques (Macaca radiata) undergoing acute infusions of yohimbine, a noradrenergic stimulant. Dependent measures were the magnitude of the increase of plasma cortisol and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) customarily elicited by yohimbine. Next, the effects of 6 weeks of chronic oral administration of LY354740 on baseline (postcapture) plasma cortisol and MHPG levels in comparison to the identical measure in untreated controls were assessed. Subjects chronically treated with LY354740 received yohimbine infusions which were compared to yohimbine infusions and saline infusions in non-LY354740-treated subjects. Preliminary evidence supports the view that acute LY354740 infusion resulted in a marked diminution of yohimbine-induced stress response, as manifest by a substantial attenuation of cortisol and MHPG response observed in comparison to the saline-treated yohimbine condition. Chronic oral administration of LY354740 led to postcapture baseline cortisol levels which were markedly reduced (approximately 50 percent) in comparison to untreated control subjects; however, there were no significant parallel differences in MHPG levels. Yohimbine infusions elicited an increase in cortisol and MHPG levels in both LY354740-treated and non-LY354740-treated subjects, in comparison to declines in cortisol values observed following vehicle infusions (group X time interaction; P<.0001). Chronic LY354740-treated subjects failed to achieve cortisol levels comparable in range to those of untreated subjects primarily because of their low baseline cortisol levels. In contrast, despite equivalent baselines, yohimbine-induced MHPG values were increased overall in the chronically treated group compared to the saline and yohimbine-alone groups. Thus, LY354740 markedly reduced the acute corticoid and noradrenergic response elicited by yohimbine infusion. Chronic administration of LY354740 appears to present a safe and effective mechanism to markedly down-modulate the HPA axis while retaining noradrenergic responsivity.     

Evidence for abstract, schematic knowledge of three spatial diagram representations

Spatial diagram representations such as hierarchies, matrices, and networks are important tools for thinking. Our data suggest that college students possess abstract schemas for these representations that include at least rudimentary information about their applicability conditions. In Experiment 1, subjects were better able to select the appropriate spatial diagram representation for a problem when cued to use general category information in memory about those representations than when cued to use specific example problems given during the experiment. The results of Experiment 2 showed that the superior performance in the general category condition was not based on a comparison of the test problems with examples in memory. The results of Experiment 3 showed that the superior performance was not due to learning that occurred during the experiment or to transfer appropriate processing. The General Discussion section considers the nature of students' representation schemas and the question of why college students have only rudimentary schemas for common and widely applicable diagrammatic representations.     

Does Alternating Between Masculine and Feminine Pronouns Eliminate Perceived Gender Bias in Text?

This study explores whether alternating betweenthe pronouns he and she ina text is an effective way to avoid sexist language.Participants were psychology students at a largemidwestern university and were predominately White and frommiddle-class backgrounds. Students read two versions ofan essay, one that alternated between masculine andfeminine pronouns and one that exclusively used paired, he or she-type pronouns. Readersperceived the alternating version to be biased in favorof females and lower in overall quality than the pairedversion. However, the alternating version appeared to be more effective at combating sexism,suggesting an alternating strategy may be desirable forauthors with this goal. If the author is not primarilyconcerned with increasing readers' awareness of gender issues, techniques such as pluralization or thesingular they may be moreappropriate.     

Comparison in the Development of Categories

Recent research on children's word learning has led to a paradox. Although word learning appears to be a deep source of insight into conceptual knowledge for children, preschoolers often categorize objects on the basis of shallow perceptual features such as shape. The current studies seek to resolve this discrepancy. We suggest that comparing multiple instances of a category enables children to extract deeper relational commonalities among category members. We examine 4-year-olds' categorization behaviors when asked to select a match for a target object (e.g., an apple) between a perceptually similar, out-of-kind object (e.g., a balloon) and a perceptually different category match (e.g., a banana). Children who learn a novel word as a label for multiple instances of the category are more likely to select the category match over the perceptual match. Children who learn a label for only one instance are equally likely to select either alternative. This effect is present even when individual target instances are more perceptually similar to the perceptual choice than to the category choice. We conclude that structural alignment processes may be important in the development of category understanding.     

Gender Differences in the Relation Between Neighborhood Quality and Cardiovascular Reactivity in African American Adolescents1

Although research on the influence of neighborhoods on the development of youth is growing, few researchers have examined the impact of neighborhood quality on physiological outcomes or across gender. The present experiment examined gender differences in the association of neighborhood quality and cardiovascular reactivity (increased blood pressure, BP, in response to stress) among 77 healthy African American adolescents (46% male; M age = 14 years). Participants took part in a cold-face stimulus task to determine reactivity scores. After controlling for baseline BP, family income, and parental education, poorer neighborhood quality was associated with increases in both systolic and diastolic BP to the cold-face task for females, and decreases in BP for males. Adolescents’ reports of life stress and support from family members did not explain the differential effect of neighborhood quality across gender. Implications for future research are discussed.