Similarities and Differences in Semantic and Phonological Processing with Age Patterns of Functional MRI Activation

Abstract

In a study modelled after Hashtroudi, Johnson, and Chrosniak (1989), young and older adults were examined in two conditions requiring reality monitoring (i.e., discriminating between one external and one internal source) and two conditions requiring source monitoring (i.e., discriminating between two external or two internal sources). Results indicated age-related deficits in internal source monitoring, although the two age groups did not differ in reality monitoring or external source monitoring. Explicit instructions to remember the source of information had no effect on performance. In addition, performance on putative tests of frontal lobe functioning (i.e., the Wisconsin Card Sorting Test and tests of verbal fluency) was unrelated to source memory performance. the results are discussed relative to the view that aging may affect the ability to encode perceptual information in a distinctive manner, as well as the ability to reconstruct perceptual information and its relationship to item information.     

Differential Memory Test Sensitivity for Diagnosing Amnestic Mild Cognitive Impairment and Predicting Conversion to Alzheimer's Disease

ABSTRACT

Episodic memory is the first and most severely affected cognitive domain in Alzheimer's disease (AD), and it is also the key early marker in prodromal stages including amnestic mild cognitive impairment (MCI). The relative ability of memory tests to discriminate between MCI and normal aging has not been well characterized. We compared the classification value of widely used verbal memory tests in distinguishing healthy older adults (n = 51) from those with MCI (n = 38). Univariate logistic regression indicated that the total learning score from the California Verbal Learning Test-II (CVLT-II) ranked highest in terms of distinguishing MCI from normal aging (sensitivity = 90.2; specificity = 84.2). Inclusion of the delayed recall condition of a story memory task (i.e., WMS-III Logical Memory, Story A) enhanced the overall accuracy of classification (sensitivity = 92.2; specificity = 94.7). Combining Logical Memory recognition and CVLT-II long delay best predicted progression from MCI to AD over a 4-year period (accurate classification = 87.5%). Learning across multiple trials may provide the most sensitive index for initial diagnosis of MCI, but inclusion of additional variables may enhance overall accuracy and may represent the optimal strategy for identifying individuals most likely to progress to dementia.     

Why Teach Literature and Medicine? Answers from Three Decades

In this essay, I look back at some of the earliest attempts by the first generation of literature-and-medicine scholars to answer the question: Why teach literature and medicine? Reviewing the development of the field in its early years, I examine statements by practitioners to see whether their answers have held up over time and to consider how the rationales they articulated have expanded or changed in the following years and why. Greater emphasis on literary criticism, narrative ethics, narrative theory, and reflective writing has influenced current work in the field in ways that could not have been foreseen in the 1970s. The extraordinary growth of interest and work in the field nationally and, especially since 1996, internationally has included practitioners in many additional areas such as disability studies, film studies, therapeutic writing, and trauma studies. Along with the emergence of narrative medicine, this diverse community of scholars and practitioners—affiliated more through their use of narrative methodologies than the teaching of literature—makes the perennial challenge of evaluation and assessment even more complicated.     

The Establishment of Core Competencies for Canadian Genetic Counsellors: Validation of Practice Based Competencies

Numerous groups of health professionals have undertaken the task of defining core competencies for their profession. The goal of establishing core competencies is to have a defined standard for such professional needs as practice guidelines, training curricula, certification, continuing competency and re-entry to practice. In 2006, the Canadian Association of Genetic Counsellors (CAGC) recognized the need for uniform practice standards for the profession in Canada, given the rapid progress of genetic knowledge and technologies, the expanding practice of genetic counsellors and the increasing demand for services. We report here the process by which the CAGC Practice Based Competencies were developed and then validated via two survey cycles, the first within the CAGC membership, and the second with feedback from external stakeholders. These competencies were formally approved in 2012 and describe the integrated skills, attitudes and judgment that genetic counsellors in Canada require in order to perform the services and duties that fall within the practice of the profession responsibly, safely, effectively and ethically.     

Explaining the Relationship Among Fundamentalism and Authoritarianism: An Epistemic Connection

Although numerous studies have documented a strong, positive association between Right-wing Authoritarianism (RWA) and Religious Fundamentalism (RF), little empirical work has actually investigated the reasons for this relationship. In the present study we propose that a fundamentalist meaning system predicts a system of beliefs about knowledge and knowing (e.g., personal epistemology), which is then partially responsible for sustaining authoritarian attitudes. A convenience sample of 227 undergraduate students was given the RWA scale, the Epistemic Belief Inventory, and the Revised Religious Fundamentalism scale in an online survey. A partial mediation model was tested using structural equation modeling analysis, in which 2,000 bootstraps were taken from the observed covariance matrix to construct confidence intervals around each indirect effect. Findings from the present study support the partial mediation hypothesis, in which the effect of RF to RWA travels through belief in certain knowledge, simple knowledge, and omniscient authority.     

Children with social phobia have lower quality friendships than children with other anxiety disorders

Background and Objective: Whilst shy, socially anxious or socially withdrawn children in nonclinical community samples report lower friendship quality (FQ) than nonanxious children, no study has examined the FQ of clinically anxious children. The aim of the study was to examine the FQ of children with anxiety disorders; and whether it differs for clinical children with or without a diagnosis of social phobia (SP). Design: The study design was cross-sectional self-report. Methods: Clinical children – 39 anxiety-disordered children with SP and 28 anxiety-disordered children without SP (No-SP) – presented for psychological treatment, and 29 nonclinical children were recruited from the community. Same-sex close friends were invited to participate using an unrestricted nomination procedure. All children were aged between 7 and 13 years. Both target child and friend completed the Friendship Quality Questionnaire and the Spence Children's Anxiety Scale. Results: Using multilevel modeling within the framework of the Actor–Partner Interdependence Model, SP dyads were found to report lower overall FQ than No-SP dyads. SP dyads did not report lower overall FQ than nonclinical dyads. Conclusion: Children with SP in their diagnostic profile may be unique in their friendship experiences relative to children with other anxiety disorders.     

Performance of an Adapted Version of the Timed Up-and-Go Test in People with Cognitive Impairments

In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among groups. A cross-sectional study was conducted with 118 community-dwelling older adults divided in three groups: PC (n?=?40), MCI (n?=?40) and AD (n?=?38). The evaluation was composed by the adapted TUGT and cognitive assessment (Addenbrooke's Cognitive Examination and Frontal Assessment Battery). Only the cadence of TUGT presented significant difference between groups, specifically between AD versus MCI and PC groups. The main correlations were found between time of TUGT with fluency domain and global cognitive function, especially in the AD Group. The findings contribute to the understanding of how cognition interferes on functional mobility in older people with MCI and AD. The adapted TUGT is easy to perform in clinical practice and can be useful when assessing mobility in people with cognitive impairment.     

New Strategies in the Assessment of Psychological Factors Affecting Medical Conditions

In this article, we examine research that may lead to a better assessment of psychological factors affecting medical conditions. We performed a review of the psychosomatic literature using both Medline and manual searches. We selected papers that were judged to be relevant to new strategies of assessment, with particular reference to the use of the Diagnostic Criteria for Psychosomatic Research. We assessed 8 areas concerned with the assessment of psychological factors in the setting of medical disease: hypochondriasis, disease phobia, persistent somatization, conversion symptoms, illness denial, demoralization, irritable mood, and Type A behavior. A new subclassification of the Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-V]; not yet published) category of psychological factors affecting physical conditions appears to be feasible and may provide the clinician with better tools for identifying psychological distress.