A review of patient outcomes in pharmacological studies from the psychiatric literature, 1966–1993

A literature search was conducted on studies of new drugs used with patients with schizophrenia reported by U.S. and non-U.S. researchers from 1966–1993, yielding 41 U.S., and a total of 24 other non-U.S. studies, among them 11 British studies. Results of the U.S. and non-U.S. studies were pooled separately and compared. Among several comparable conditions discussed, the lack of any data on suicides in the U.S. studies was observed. For a second statistical analysis of suicide rates ‘person-years’ were calculated to adjust for differing washout durations. The results obtained include findings that the percentage of patients relapsing in U.S. studies was slightly lower (37.9%) than in non-U.S. studies (46%); the percentage of patients dropping out in U.S. studies (10.5%) was higher than in non-U.S. studies (7.6%); known location of dropout patients in U.S. studies was 1.7%, compared to 2.6% in non-U.S. studies. The most interesting finding was that no suicides were reported in U.S. studies, compared to 0.6% of patients reported in British studies. Some U.S. studies used ‘challenge doses’, such as amphetamines or L-dopa; no non-U.S. studies reported their use. Compared to U.S. studies, those by non-U.S., and particularly British, researchers appeared to report adverse events in their studies. ‘Challenge’ drugs were not used; suicides were reported. It is estimated that the probability that no patients suicided who participated in the U.S. is small—one in 500.     

The lost e-mail method: Milgram’s lost-letter technique in the age of the Internet

We examined Milgram’s (1977) lost-letter technique using e-mail. In the first experiment, 79 college faculty received mock lost e-mail messages. Nineteen percent of those who received the messages responded, in all cases by returning the message to the “sender” instead of forwarding it to the “recipient.” In the second study, attitudes toward presidential candidate Ross Perot were examined by sending out two different messages to 200 randomly selected e-mail addresses in the United States. Although there was no differential response rate, examination of content revealed attitudes consistent with concurrent poll data.     

TheP system: A scheme for organizing Pavlovian procedures

The present paper introduces theP system as a scheme for organizing Pavlovian procedures in an orderly and comprehensive manner. The system is defined by three temporal variables and three restrictions on their possible values. It can be used to define all standard temporal variables—namely, stimulus duration, interstimulus interval, trace interval, and intertrial interval—as well as variables C and T of scalar expectancy theory. The system also permits the definition of new independent variables through combinations of the basic temporal parameters. We exemplify this possibility by defining two ratios of temporal intervals. These ratios lead to a space where traditional Pavlovian arrangements (viz., simultaneous, forward-trace, forward-delay, backward) become points on a continuum, and optimal conditions across different experimental preparations become equivalent. Finally, the system can be used to define contingency variables such asp(US/CS),p(US/～CS), and the phi coefficient (φ). In this manner, an organization of different kinds of Pavlovian procedures is achieved on the basis of a single parametric scheme. Such an organization facilitates establishing procedural and theoretical relationships between temporal and contingency variables. The paper concludes with a discussion of certain limitations of the system and other related issues     

A motor timing experiment implemented using a musical instrument digital interface (MIDI) approach

The musical instrument digital interface (MIDI) offers a way for perception and behavior researchers to implement high-quality experiments using inexpensive, commercially available hardware and software. We describe the MIDI and illustrate its applicability to research using a replication of the oscillator signature finding reported recently by Collyer, Broadbent, and Church (1992, 1994).     

Internalizing and externalizing characteristics of sexually and/or physically abused children

This study evaluates the behavioral consequences of childhood abuse (sexual, physical, or both), with particular focus on prevalence of posttraumatic stress disorder (PTSD). Three abuse type groups and nonabused controls were contrasted on behavioral rating scales and on structured psychiatric interview data. The participants (109 abused children and 16 normal control children) were recruited from Arkansas Children’s Hospital and local agencies for abused children. As expected, proportionately more females than males were sexually abused. Overall, males were rated as more disturbed than females. Type of abuse did not consistently influence behavioral ratings. Externalizing scores were significantly higher than internalizing scores in all abused groups. PTSD was diagnosed in 50% of the abused children, with a higher rate for boys who had been sexually abused as opposed to physically abused only (58% versus 13%). The most frequent comorbid condition with PTSD was Separation Anxiety. Sexually abused boys were hospitalized for psychiatric treatment at a higher rate than were other abused children.     

Heading and path information from retinal flow in naturalistic environments

In four experiments, we explored the heading and path information available to observers as we simulated their locomotion through a cluttered environment while they fixated an object off to the side. Previously, we presented a theory about the information available and used in such situations. For such a theory to be valid, one must be sure of eye position, but we had been unable to monitor gaze systematically; in Experiment 1, we monitored eye position and found performance best when observers fixated the designated object at the center of the display. In Experiment 2, when we masked portions of the display, we found that performance generally matched the amount of display visible when scaled to retinal sensitivity. In Experiments 3 and 4, we then explored the metric of information about heading (nominal vs. absolute) available and found good nominal information but increasingly poor and biased absolute information as observers looked farther from the aimpoint. Part of the cause for this appears to be that some observers perceive that they have traversed a curved path even when taking a linear one. In all cases, we compared our results with those in the literature.