A Review of Recent FDA Drug Safety Communications for Pediatric Psychotropics

To alert professionals and consumers about safety risks associated with approved drugs, the U.S. Food and Drug Administration (FDA) periodically issues Drug Safety Communications, or DSCs (previously known as advisories, warnings, and health care professional letters). This review consolidates balanced information from 22 DSCs issued over the last 15 years by the FDA for drugs with pediatric indications (for any disorder) that are used to treat pediatric emotional and behavioral disorders (ADHD drugs, antipsychotics, antidepressants, and antiepileptics/anticonvulsants). A single-source document of pediatric DSCs for these drugs was needed because none existed previously; finding DSC information on the FDA website can be challenging; and other information sources (e.g., manufacturer or advocacy websites, blogs, other media reports) may lack the objectivity or accuracy that the FDA is charged to maintain. This consolidation is intended to enable better informed risk-benefit analysis around treatment selection and drug safety monitoring. For the 22 DSCs, we summarize the safety concerns, the populations affected, and when available from the FDA, the incidence of the adverse events, precursors, and factors that may increase or mitigate the risk of these very serious (e.g., sudden death, life-threatening rash, liver failure), but typically low incidence (<1 %) adverse events (cardiometabolic complications with atypical antipsychotics and suicidality with antidepressants are more common). This review does not address the far more common, but usually less serious, side effects that also accompany these drugs. Implications of this review for research and practice are discussed.     

Between Black and White: Examining Grey Literature in Meta-analyses of Psychological Research

The inclusion of grey literature in meta-analyses and reviews is controversial. We examine both the advantages and challenges of including grey literature in meta-analyses. An exemplar meta-analysis of behavioral parenting interventions on parent behavior, child behavior, and parent adjustment outcomes is used to demonstrate these issues. It also explores the influence of the inclusion of grey literature on outcomes, including whether effect sizes are affected by the inclusion of grey literature and describes the challenges of searching for grey literature using traditional search engines such as Google and Yahoo. Homogeneity and publication bias are also examined. Based on these results, recommendations are presented for meta-analysts and researchers.     

Scaling space with the mirror illusion: The influence of body plasticity on perceived affordances

How do body representations influence decisions about action? We developed a novel paradigm using the mirror illusion (Holmes, Crozier, & Spence, in Cognitive, Affective, & Behavioral Neuroscience, 4, 193–200, 2004) to examine two ways of evoking body plasticity—extension of body capabilities and visual capture—and its influence on perceived affordances. In two experiments, we manipulated the action capabilities of a seen left hand by lengthening the arm with a rod (Exp. 1) or enlarging the hand with a glove (Exp. 2). The right hand was unaltered physically and was occluded by placement in a mirror box. We induced visual capture through synchronous finger movements of both hands. Right-hand estimates of reaching and of fitting through apertures increased relative to actual capabilities during visual capture, supporting the claim that visual capture can induce the incorporation of an apparent body extension into action decisions. The results suggest that both perceptual and cognitive influences on bodily awareness underlie perceived affordances.     

Domain‐specific development of face memory but not face perception

How does the remarkable human ability for face recognition arise over development? Competing theories have proposed either late maturity (beyond 10 years) or early maturity (before 5 years), but have not distinguished between perceptual and memory aspects of face recognition. Here, we demonstrate a perception–memory dissociation. We compare rate of development for (adult, human) faces versus other social stimuli (bodies), other discrete objects (cars), and other categories processed in discrete brain regions (scenes, bodies), from 5 years to adulthood. For perceptual discrimination, performance improved with age at the same rate for faces and all other categories, indicating no domain‐specific development. In contrast, face memory increased more strongly than non‐face memory, indicating domain‐specific development. The results imply that each theory is partly true: the late maturity theory holds for face memory, and the early maturity theory for face perception.     

Social comparison mediates chimpanzees’ responses to loss,not frustration

Why do chimpanzees react when their partner gets a better deal than them? Do they note the inequity or do their responses reflect frustration in response to unattainable rewards? To tease apart inequity and contrast, we tested chimpanzees in a series of conditions that created loss through individual contrast, through inequity, or by both. Chimpanzees were tested in four social and two individual conditions in which they received food rewards in return for exchanging tokens with an experimenter. In conditions designed to create individual contrast, after completing an exchange, the chimpanzees were given a relatively less-preferred reward than the one they were previously shown. The chimpanzees’ willingness to accept the less-preferred rewards was independent of previously offered foods in both the social and individual conditions. In conditions that created frustration through inequity, subjects were given a less-preferred reward than the one received by their partner, but not in relation to the reward they were previously offered. In a social context, females were more likely to refuse to participate when they received a less-preferred reward than their partner (disadvantageous inequity), than when they received a more-preferred reward (advantageous inequity). Specifically, the females’ refusals were typified by refusals to exchange tokens rather than refusals to accept food rewards. Males showed no difference in their responses to inequity or individual contrast. These results support previous evidence that some chimpanzees’ responses to inequity are mediated more strongly by what others receive than by frustration effects.     

Beyond Numbers Versus Rights: Shifting the Parameters of Debate on Temporary Labour Migration

This paper seeks to move beyond what Martin and Ruhs described as the numbers versus rights equation in temporary labour migration programs. We do this by examining the ideology of temporary labour migration. This ideology has three key elements: temporariness, labour markets and rights. The paper describes how these concepts obscure key features of temporary labour migration programs. The argument is developed by examining points of contrast between current programs in place in the USA, Canada, Australia and the UK. The paper concludes by demonstrating how unmasking the power imbalances of this ideology will lead to new policy directions.     

The Nature and Predictive Value of Mothers' Beliefs Regarding Infants' and Toddlers' TV/Video Viewing: Applying the Integrative Model of Behavioral Prediction

Viewing television and video programming has become a normative behavior among U.S. infants and toddlers. Little is understood about the extent of parents' decision making regarding their young children's viewing, although numerous organizations are interested in reducing time spent viewing among infants and toddlers. Prior research has examined parents' belief in the educational value of TV/videos for young children and the predictive value of this belief for understanding infant and toddler viewing rates, although other possible salient beliefs remain largely unexplored. This study employs the integrative model of behavioral prediction to examine 30 maternal beliefs about infants' and toddlers' TV/video viewing, which were elicited from a prior sample of mothers. Results indicate that mothers tend to hold more positive than negative beliefs about the outcomes associated with young children's TV/video viewing and that the nature of the aggregate set of beliefs is predictive of their general attitudes and intentions to allow their children to view, as well as children's estimated viewing rates. Analyses also uncover multiple dimensions within the full set of beliefs, which explain more variance in mothers' attitudes and intentions and children's viewing than the uni-dimensional index. The theoretical and practical implications of the findings are discussed.     

A critical review of relationship quality measures: Is a fresh start needed? An agenda to move forward

Social relationships in and around work are a fundamental building block of organizational life. According to a number of relationship theories, the quality of those relationships is a critical aspect of their influence on a variety of employee and organizational outcomes. Relationship quality is, therefore, one of the most commonly studied constructs in management research. Our paper critically reviews the landscape of relationship quality measures used in management studies, identifying critical issues with how the construct has been conceptualized and measured. To help advance research on the subject and improve measurement, we identify and evaluate 21 relationship quality measures that have been developed for, or used in, management research. Overall, we find that the instruments used to measure relationship quality in management research have significant limitations associated with their conceptualizations and operationalizations. Many of these limitations stem from the fact that most of the measures used to assess the construct were not originally designed to measure relationship quality, which impedes research clarity and implications. We offer a future research agenda and several recommendations for the advancement of management research on relationship quality.     

Strengthening Communities: A Qualitative Assessment of Opportunities for the Prevention of Adverse Childhood Experiences in the Wake of the Opioid Crisis

Journal of Child and Family Studies - The opioid crisis is a significant challenge for health and human service systems that serve children, youth, and families across the United States. Between...