Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Neurodegen erative disorders such as Alzheimer’s disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.     

Predictors and outcomes of persistent or age‐limited registered criminal behavior: a 30‐year longitudinal study of a Swedish urban population

This study uses data from the longitudinal research program Individual Development and Adaptation, where an entire school‐grade cohort of children in a middle‐size Swedish city (n～1.300) has been followed from ages 10 to 43 and 48 for women and men, respectively. Our findings indicate that the patterns of offending across the life‐course differ between genders, where males seem to initiate their offending earlier than females. Further, there are very few women on a persistent offending‐trajectory. Focusing on precursors to as well as consequences of offending as indexed in official registers, our results indicate that individuals in the persistent offender group have the most pronounced adjustment problems in school‐ as well as in middle age. Individual characteristics and behaviors (e.g., aggression, hyperactivity, antisocial behavior) vary systematically between individuals with different developmental offending patterns. The combination of an unstable upbringing and own antisocial behavior seems to be especially predictive for criminality. For persistent offenders, the prevalence of alcohol and psychiatric problems at adult age is high for males and extremely high for females (nine out of ten and six out of ten for each of the two problem types for females). Further, the importance for adjustment of the two‐dimensional variation in the number of crimes committed during adolescence and adult age seems to have been surprisingly well captured by the “crude” division into the four offender groups that were used. Aggr. Behav. 35:164–178, 2009. © 2009 Wiley‐Liss, Inc.     

Incidental retrieval processes influence explicit test performance with data-limited cues

In two experiments, the influence of incidental retrieval processes on explicit test performance was tested. In Experiment 1, subjects studied words under four conditions (auditory-shallow, auditory-deep, visual-shallow, and visual-deep). One group of subjects received auditory and visual word-fragment completion; another group received auditory and visual word-fragment cued recall. Results indicated that changes in sensory modality between study and test reduced both recall and priming performances; levels of processing significantly affected only the cued recall test. These results indicated that incidental retrieval processes might affect explicit test performance when retrieval cues are data limited. Experiment 2 supported this conclusion by showing an effect of matching study and test modalities on explicit test performance with fragment but not with copy cues. Taken together, these results support Roediger and McDermott’s (1993) suggestion that explicit test performance is influenced by incidental retrieval processes when data-limited retrieval cues are used.     

Is all therapy just a placebo effect?

The epistemological soundness of controlled clinical trials is questioned. It is argued that the real effect of therapies cannot be determined by such experiments because there is a significant interaction between the placebo effect and real effect created by the individual therapist and treatment situation which, however, is neglected in controlled clinical trials. This critical standpoint is supported by several pharmacological examples.     

Gerotranscendence and the Functions of Reminiscence

In the present investigation, different functions of reminiscence have been empirically studied in relation to the developmental changes described in the theory of gerotranscendence, a theory dealing with human development towards maturity and wisdom. The phenomenon of gerotranscendence and the functions of reminiscence are, according to our analyses, intertwined. Since gerotranscendence is largely about the change and reconstruction of identity and personal frames of reference, this also means that the common continuity-oriented theoretical perspective on reminiscence has to be questioned. Reminiscence can have functions other than that of stabilizing an already developed identity. It can just as well play an instrumental role in developmental change and reconstruction of the identity and in our perception of the world.     

A component analysis of action events

Summary Three experiments are reported, that examine the basis of the recall superiority of subject-performed tasks (SPTs) over verbal-memory tasks (VTs), and the interitem variability for SPTs. In Experiments 1 and 2 a component analysis of SPTs is undertaken in order to explore the importance of (a) involvement of external objects, (b) multimodality, and (c) enactment, for the superior memory performance for SPTs over that for VTs. In Experiment 3 the role of retrieval support, in terms of a high degree of match between the encoding and retrieval situations, was investigated in order to find out why some SPTs are easier to recall than others. The results indicate that it is difficult to separate out a single component as the most critical one for the superiority of SPT recall over VT recall, and that a high degree of match between encoding and retrieval conditions improves SPT recall. It is suggested that, in order to explain the large differences in memorability between SPTs and VTs, it is sufficient to consider the more supportive encoding situation for SPTs, but to explain differences in recallability between various SPTs, the compatibility between encoding and test has to be taken into consideration.     

Health care need: three interpretations

The argument that scarce health care resources should be distributed so that patients in 'need' are given priority for treatment is rarely contested. In this paper, we argue that if need is to play a significant role in distributive decisions it is crucial that what is meant by need can be precisely articulated. Following a discussion of the general features of health care need, we propose three principal interpretations of need, each of which focuses on separate intuitions. Although this account may not be a completely exhaustive reflection of what people mean when they refer to need, the three interpretations provide a starting-point for further debate of what the concept means in its specific application. We discuss combined interpretations, the meaning of grading needs, and compare needs-based priority setting to social welfare maximisation.     

Common fronto-parietal activity in attention, memory, and consciousness: shared demands on integration?

Fronto-parietal activity has been frequently observed in fMRI and PET studies of attention, working memory, and episodic memory retrieval. Several recent fMRI studies have also reported fronto-parietal activity during conscious visual perception. A major goal of this review was to assess the degree of anatomical overlap among activation patterns associated with these four functions. A second goal was to shed light on the possible cognitive relationship of processes that relate to common brain activity across functions. For all reviewed functions we observed a consistent and overlapping pattern of brain activity. The overlap was most pronounced for the bilateral parietal cortex (BA 7 and BA 40; close to the intraparietal sulcus), and dorsolateral prefrontal cortex (right BA 9 and left BA 6). The common fronto-parietal activity will be discussed in terms of processes related to integration of distributed representations in the brain.     

The predictive validity of nonverbal communicative skills in infants with perinatal hazards

This study investigated the predictive validity to 5 years of age of nonverbal communicative skills administered at 13 months. Subjects (N = 103) were Norwegian infants with birthweight below 1501 gms. The predictors included infant competence assessed by the Early Social-Communication Scales (ESCS). Cognitive competence at 2 years was measured by the Bayley Mental Development Scale, and at 3 and 5 years by the Stanford-Binet Intelligence Scale: Fourth Edition (SB:FE). Language competence at 2 and 3 years was assessed by the Reynell Developmental Language Scales, and at 5 years by a verbal comprehension factor derived from the SB:FE. Partial correlations and multiple regression analyses suggest that the infants' initiation of communication was related to cognitive ability and language skills up to 5 years of age. In particular, joint attention was the most consistent predictor of the subsequent competencies. The Bayley cognitive index was overruled as a predictor when used in combination with initiation of joint attention.     

The role of enactment in implicit and explicit memory

Enactment during the encoding of simple imperatives has been found to improve substantially performance on conceptually driven explicit-memory tests. In two experiments the effect of this manipulation on a conceptually driven implicit test (category association) was studied. A conceptually driven explicit test (free recall) was also included. In Experiment one three different study conditions (enactment with real objects, reading, and generation) were considered. In Experiment two there were two study conditions (enactment with imaginary objects and reading). Compared to reading, generation was found to improve the performance on both free recall and category association, whereas enactment affected free recall only. In a final experiment subjects imagined that they performed the tasks, and this manipulation was found to improve the memory performance on both tests. Taken together, this pattern of results is interpreted as suggesting that free recall and category association have a process in common that is sensitive to semantic processing at study (promoted by generation and imagery, but not by enactment), and that free recall involves a retrieval process in addition that is facilitated by a rich encoding environment (provided by enactment).