前临床期痴呆的认知特征：当前研究进展和未来研究展望

在这篇文章中, 我将讨论从正常老化到痴呆, 这一通常被称为痴呆前临床阶段的认知功能的转变。研究表明, 阿尔茨海默症和血管性痴呆病人在临床确诊之前的几年中, 会出现明显的认知损伤。早期最突出的损伤存在于情节记忆、加工速度以及执行功能。这些功能性损伤与神经生物学研究证实的边缘系统和新皮层区存在多重损伤是相一致的。虽然早在临床诊段之前, 病人组和控制组的平均成绩存在巨大差异, 但同时这两组测试成绩的分布在很大程度上是重叠的。寻求降低这种重叠度的方法是未来研究的一个重要任务。这有可能通过将认知的和其他指标(如基于脑的、基因的、临床的、社会的)相结合构建预测模型来实现。此外, 在未来研究中以下三方面也是急需考虑问题: (a) 找出在 前临床期间认知功能急速下降的时间点: (b) 评估从前临床到临床诊断变化速率中存在的个体差异; (c) 确定特定因素与随后发生的痴呆之间的关联强度是如何随时间向临床确诊推进而逐渐变化的。     

Neural correlates of variable working memory load across adult age and skill: dissociative patterns within the fronto-parietal network

We examined neural changes related to variations in working memory load by using an n -back task with three levels and functional magnetic resonance imaging. Younger adults were divided into high- and low-performing groups (Young-High; Young-Low) and compared with older adults. Relative to Young-High, capacity-constraints in working memory were apparent between load 1–2 for the elderly and between load 2–3 for Young-Low. Capacity-constraints in neural activity followed this pattern by showing a monotonically increasing response in parietal cortex and thalamus for Young-High, whereas activity leveled off at 1-back for the elderly and at 2-back for Young-Low. The response in dorsal frontal cortex followed a similar pattern with the addition that the magnitude of activation differed within capacity limitations (Old > Young at 1-back; Young-Low > Young-High at 2-back). These findings indicate that an important determinant of WM capacity is the ability to keep the frontal cortex adequately engaged in relation to current task demands.     

Interpersonal Problems Among Perpetrators and Targets of Workplace Bullying

This representative study among 2,539 Norwegian employees examines interpersonal problems among targets and perpetrators of workplace bullying. Both targets and perpetrators portrayed elevated levels of interpersonal problems. Yet, the results question the role of a general target personality in explaining exposure to workplace bullying. Although interpersonal problems were reported among 50% of the targets, interpersonal problems were also prevalent in a large proportion of the non-exposed employees. Accordingly, level of interpersonal problems does not easily differentiate targets from non-targets and calls for a broader frame of reference in order to understand the bullying process.     

Brain dynamics of word familiarization in 20-month-olds: effects of productive vocabulary size

The present study investigated the brain mechanisms involved during young children's receptive familiarization with new words, and whether the dynamics of these mechanisms are related to the child's productive vocabulary size. To this end, we recorded event-related potentials (ERPs) from 20-month-old children in a pseudoword repetition task. Results revealed distinct patterns of repetition effects for children with large and small productive vocabularies. High producers showed evidence of recognizing the novel words already after three presentations, while the low producers needed five presentations to display a recognition effect. The familiarization process was manifested in the modulations of two components, the N200-400 and a later fronto-central component, which appeared to increase in amplitude until a certain level of encoding was reached and then decrease with further repetition. These findings suggest a relation between the onset of the productive vocabulary spurt and the rate of receptive word familiarization.     

A comparison of psychoanalytic and psychodramatic theory from a psychodramatist's perspective

A comparison of Freud's and Moreno's theories with regard to their implications for psychodrama therapy. Basic differences in the theories are discussed with special regard to therapist role, transference and tele, insight and catharsis, the time concept, the body, and developmental psychology. Other topics treated are concepts of drive or energy, psychic structure and role theory, psychic determinism contra the doctrine of spontaneity-creativity and differences between an intrapsychic and an interpersonal approach. An outline of the relationship of psychodrama and its philosophy and practice to other schools of psychotherapy is given.     

CAN-4, an advanced author language for CAI,computer-based testing and psychological experimentation: PDP-9 implementation

The effective use of computers for tutorial (programmed instruction) teaching and on-line testing requires that curriculum authors have powerful special-purpose languages. One such language, CAN-4, has been designed and implemented to run on the PDP-9. The language includes advanced scoring, data recording, computation, timing, and file control facilities. The language and its implementation are described in relation to the instructional problems which the facilities are designed to meet.