Randomized controlled trial of internet-based stress management

This study investigated the effects of an internet-based self-help stress management program with a randomized controlled design. Of 85 participants, 26% dropped out, leaving a final sample of 63 participants with 23 in the treatment group and 40 in the waiting list control group. Treatment included applied relaxation, problem solving, time management and cognitive restructuring. All information and treatment interventions were provided via the internet. Results were evaluated with the Perceived Stress Scale and the Hospital Anxiety and Depression Scale. Improvements were seen in both groups, with greater improvements in the self-help treatment group. It is concluded that the internet can be used to provide stress management techniques and result in stress relief. However, spontaneous improvement, differential dropout rate and compliance need to be monitored in future studies.     

Development of spatial memory and spatial orientation in preschoolers and primary school children

The present study addresses the question of what kind of information children use when orientating in new environments, if given proximal and distal landmarks, and how spatial memory develops in the investigated age groups. Ten 5-year-old, ten 7-year-old and ten 10-year-old children were presented with the ‘Kiel Locomotor Maze’, containing features of the Radial Arm Maze and the Morris Water Maze, in order to assess spatial memory and orientation. Children had to learn to approach baited locations only. Task difficulty was equated with respect to the children's age. Training was given until the children reached criterion. During testing, the maze configuration and response requirements were systematically altered, including response rotation, cue rotation, cue deletion and response rotation with cue deletion in order to assess the spatial strategies used by the children. During training and testing, working-memory errors (WM), reference-memory errors (RM) and working-reference memory errors (WR) were recorded. As expected, no difference between age groups appeared during training, thus confirming comparable task difficulty across age groups. During testing, age groups differed significantly with regard to the orientation strategy used. The 5-year-olds were bound to a cue strategy, orientating towards local, proximal cues. The 10-year-olds mastered all tasks, thus displaying a place strategy, being able to use distal cues for orientation, and were even able to do so after being rotated 180°. The 7-year-olds proved to be at an age of transition: five of them were bound to a cue strategy, five children were able to adopt a place strategy. The differences in the orientation strategies used by children of different age groups was reflected by the sum of errors they made, also by RM. WM were found to be rare, especially in older children. We conclude that preschoolers use a cue strategy, that the development of place strategies occurs during primary school age and seems to be complete by the age of 10 years.     

The dual-conception view reexamined: attentional demands and the encoding of verbal and physical information in action events

In two experiments the influence of attentional demands at encoding on recall of different features of subject-performed tasks (SPTs) was studied. In Experiment 1, memory of verbs and colors of objects was tested, with object names serving as cues. In Experiment 2, object and color memory were tested, with verbs serving as cues. Results from both experiments indicated that SPTs were affected by divided attention at encoding. In contrast to previous research, verbal and physical properties of SPTs were not differently affected by the requirements of dual-task performance (i. e., the combination of an SPT task and a secondary task). The results are discussed in terms of the nature of the secondary task.     

Time to Death and Cognitive Performance

We review a program of research that examines people's judgments about how they are seen by others. The research indicates that people tend to anchor on their own experience when making such judgments, with the result that their assessments are often egocentrically biased. Our review focuses on two biases in particular, the spotlight effect, or people's tendency to overestimate the extent to which their behavior and appearance are noticed and evaluated by others, and the illusion of transparency, or people's tendency to overestimate the extent to which their internal states "leak out" and are detectable by others.     

Brain activation while forming memories of fearful and neutral faces in women and men

Event-related functional MRI (fMRI) was used to assess brain activity during encoding of fearful and neutral faces in 12 women and 12 men. In a subsequent memory analysis, the authors separated successful from unsuccessful encoding of both types of faces, based on whether they were remembered or forgotten in a later recognition memory test. Overall, women and men recruited overlapping neural circuitries. Both sexes activated right-sided medial-temporal regions during successful encoding of fearful faces. Successful encoding of neutral faces was associated with left-sided lateral prefrontal and right-sided superior frontal activation in both sexes. In women, relatively greater encoding related activity for neutral faces was seen in the superior parietal and parahippocampal cortices. By contrast, men activated the left and right superior/middle frontal cortex more than women during successful encoding of the same neutral faces. These findings suggest that women and men use similar neural networks to encode facial information, with only subtle sex differences observed for neutral faces.     

Stress modulates the use of spatial versus stimulus-response learning strategies in humans

Animal studies provided evidence that stress modulates multiple memory systems, favoring caudate nucleus-based "habit" memory over hippocampus-based "cognitive" memory. However, effects of stress on learning strategy and memory consolidation were not differentiated. We specifically address the effects of psychosocial stress on the applied learning strategy in humans. We designed a spatial learning task that allowed differentiating spatial from stimulus-response learning strategies during acquisition. In 13 subsequent trials, participants (88 male and female students) had to locate a "win" card out of four placed at a fixed location in a 3D model of a room. Relocating one cue in the last trial allowed inferring the applied learning strategy. Half of them participated first in the "Trier Social Stress Test." Salivary cortisol and heart rate measurements were taken. Stressed participants used a stimulus-response strategy significantly more often than controls. Subsequent verbal report revealed that spatial learners had a more complete awareness of response options than stimulus-response learners. Importantly, learning performance was not affected by stress. Taken together, stress prior to learning facilitated simple stimulus-response learning strategies in humans-at the expense of a more cognitive learning strategy. Depending on the context, we consider this as an adaptive response.     

Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Neurodegen erative disorders such as Alzheimer’s disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.