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201.
Cellular memory in spinal nociceptive circuitry 总被引:8,自引:0,他引:8
Besides transmitting and processing, neurons may also store information for prolonged periods of time (e.g. by use-dependent change in synaptic strength). In 1966 long-term potentiation (LTP) of synaptic transmission was discovered in the hippocampus, an area implicated in learning and memory. Recent studies show that similar mechanisms apply to pain pathways, at least in the spinal cord, and may account for some forms of clinical problems like hyperalgesia, allodynia, and deafferentation pain states, such as phantom pain. In this review, we briefly summarize key aspects of synaptic plasticity known from the brain and in the spinal cord. Then we describe and discuss related changes in spinal nociceptive neurons based on results from our own laboratory. 相似文献
202.
The effects of attention on speech perception: an fMRI study 总被引:8,自引:0,他引:8
Focusing of attention to a specific speech source plays an important role in everyday speech perception. However, little is known of the neuronal substrates of focused attention in speech perception. Thus, the present study investigated the effects on neuronal activation of directed attention to auditory stimuli that differed in semantic content. Using an event-related fMRI protocol, single vowels, three-phoneme pseudowords and three- and four-phoneme real nouns and words were randomly presented to the subjects during four different instructional conditions. One condition was passive listening without any specific instructions of focusing of attention. The other conditions were attention focused on either the vowels, the pseudowords or the words. Thus, the acoustic stimulation was constant across conditions. The subjects were 13 healthy adults. Functional MRI was performed with a 1.5 T scanner, using an event-related design. During passive listening, there were significant activations bilaterally in the superior temporal gyrus. Instruction to attend to the pseudowords caused activation in middle temporal lobe areas, extending more anterior compared to the activations seen during passive listening. Instruction to attend to the vowel sounds caused an increase in activation in the superior/medial temporal lobe, with a leftward asymmetry. Instruction to attend to the words caused a leftward asymmetry, particularly in the middle and superior temporal gyri. It is concluded that attention plays a modulatory role in neuronal activation to speech sounds, producing specific activations to specific stimulus categories that may act to facilitate speech perception. 相似文献
203.
Comparisons of visual perception, response-selection, and response-execution performance were made between Type 2 diabetes mellitus patients and a matched nondiabetic control group. 10 well-controlled male patients with Type 2 diabetes without diabetic complications (M age 58 yr.) and an age and IQ-matched non-diabetic control group consisting of 13 male healthy volunteers (M age 57 yr.) were included. Significant differences were found only between the two groups on response-selection performance, which concerns the selection and preparation of an appropriate motor action. 相似文献
204.
Joseph C. Nah Marco Neppi-Modona Lars Strother Marlene Behrmann Sarah Shomstein 《Attention, perception & psychophysics》2018,80(6):1375-1389
Visual input typically includes a myriad of objects, some of which are selected for further processing. While these objects vary in shape and size, most evidence supporting object-based guidance of attention is drawn from paradigms employing two identical objects. Importantly, object size is a readily perceived stimulus dimension, and whether it modulates the distribution of attention remains an open question. Across four experiments, the size of the objects in the display was manipulated in a modified version of the two-rectangle paradigm. In Experiment 1, two identical parallel rectangles of two sizes (thin or thick) were presented. Experiments 2–4 employed identical trapezoids (each having a thin and thick end), inverted in orientation. In the experiments, one end of an object was cued and participants performed either a T/L discrimination or a simple target-detection task. Combined results show that, in addition to the standard object-based attentional advantage, there was a further attentional benefit for processing information contained in the thick versus thin end of objects. Additionally, eye-tracking measures demonstrated increased saccade precision towards thick object ends, suggesting that Fitts’s Law may play a role in object-based attentional shifts. Taken together, these results suggest that object-based attentional selection is modulated by object width. 相似文献
205.
Lars T. Lih 《Studies in East European Thought》2018,70(2-3):121-140
Kautsky’s Road to Power (Der Weg zur Macht, 1909. https://www.marxists.org/deutsch/archiv/kautsky/1909/macht/index.htm) was received in very different ways in Germany and Russia. In Germany, it earned Kautsky hostility from the trade-unionists on the right of the party and the radicals on the left. Later writers dismiss the book as preaching “revolutionary passivity.” In Russia, the Bolsheviks immediately seized on the book as an endorsement of specifically Bolshevik positions. After the war broke out, they used it to show that Kautsky was a renegade who did not live up to his stated views. In the end, Road to Power helped inspire Kautsky’s greatest fans turned fiercest foes to make what he considered a tragic mistake: the October revolution. 相似文献
206.
Peder Chr. Bryhn Nørbech Lars Fodstad Irene Kuisma Ketil Berge Lunde Ellen Hartmann 《Journal of personality assessment》2016,98(4):419-429
Recently, Hartmann and Hartmann (2014) found that psychiatric outpatients, both with and without access to Internet-based information about the Rorschach Inkblot Method (RIM; Weiner, 2003) and the MMPI–2 (Butcher, Dahlstrom, Graham, Tellegen, &; Kaemmer, 1989), were unable to imitate healthy test performance on these tests. We replicated the study by administering the RIM and the MMPI–2 to 63 incarcerated violent offenders using similar testing conditions. As in the previous study, comparisons were made not only among the 3 subgroups of incarcerated offenders, but also between these offender groups and the group of nonpatients examined in the previous study. On the RIM, Internet-coached and uncoached “faking good” offenders produced records with significantly higher F% and X–% and significantly lower M, m, SumC, X+%, P, AG, and COP than nonoffenders under standard instructions (effect sizes between d = 0.24 and d = 2.39). For AgC, AgPot, AgPast, and TCI% there were no significant differences between the faking offenders and the nonoffenders under standard instructions. On the MMPI–2 clinical scales, there were no significant differences between the faking good groups and the nonoffenders under standard instructions, except on Hs, Pd, and Sc. Both faking groups were identifiable by their high L scale scores. Although both faking groups managed to avoid giving responses with aggressive and generally psychopathological content on the RIM, they were unable to produce test profiles demonstrating healthy test performance on any of the tests; nevertheless, Internet-based test information might weaken test validity. 相似文献
207.
Examining the moral grey zone: The role of moral disengagement,authenticity, and situational strength in predicting unethical managerial behavior 下载免费PDF全文
Michael Knoll Robert G. Lord Lars‐Eric Petersen Oliver Weigelt 《Journal of applied social psychology》2016,46(1):65-78
In the business context, there is a broad spectrum of practices that potentially harm others, yet might benefit the organization. We examined the influence of individual and situational differences in predicting (un)ethical behavior in these moral gray zones using an in‐basket exercise that included covert moral issues in which managers could give unethical instructions to their followers. Results show that individual differences in moral disengagement directly predicted unethical behavior and functioned as a mediator of the relationship between authenticity and unethical behavior. Furthermore, effects differed in weak compared to strong situations. Study 2, replicated the results from Study 1, developed a direct test of the situational strength hypothesis, and showed that high versus low situation strength moderated the relation of moral disengagement to unethical behavior. 相似文献
208.
209.
Hansen LK 《Brain and language》2007,102(2):186-191
We discuss aspects of multivariate fMRI modeling, including the statistical evaluation of multivariate models and means for dimensional reduction. In a case study we analyze linear and non-linear dimensional reduction tools in the context of a 'mind reading' predictive multivariate fMRI model. 相似文献
210.
Patients with schizophrenia are at high risk of suicide. Cognitive behavior therapy (CBT) has been shown to reduce symptoms in schizophrenia. This study examines whether CBT also changes the level of suicidal ideation in patients with schizophrenia compared to a control group. Ninety ambulatory patients with symptoms of schizophrenia resistant to conventional antipsychotic medication were randomized to CBT or befriending. They were assessed using the Comprehensive Psychopathological Rating Scale, including a rating of suicidal ideation at baseline, post intervention, and after 9 months. Post-hoc analysis revealed that CBT provided significant reductions in suicidal ideation at the end of therapy, and sustained at the follow-up. Further research is required to substantiate these findings and determine the process and mechanisms through which this reduction is achieved. 相似文献