Chest pain without coronary artery disease: An exploratory comparison with panic disorder

Recent reports have indicated similarities between patients with persistent chest pain of nonorganic origin and patients with panic disorder. In order to explore this association further, we administered a structured interview and three self-report measures (State-Trait Inventory, Beck Depression Inventory, and SCL90-R) to three subject groups: (1) a sample with persistent chest pain (CP; n=14) who had been screened and found to have normal coronary arteries, (2) a sample of patients with panic disorder (PD; n=14), and (3) a sample of matched normals (n=14). CP patients were considered to be free of coronary artery disease (CAD) following normal cardiac catheterization and/or normal thallium stress tests and were not diagnosed initially with panic disorder. PD patients were diagnosed with a standardized psychiatric interview and were free of organic causes of panic. Using an exploratory data analytic approach, the results indicated that both CP and PD samples reported increased levels of state and trait anxiety (p <.0001), depression (p <.01), and somatization (p <.0001) compared with normals. CP patients differed from PD patients in their less frequent use of anxiolytic medication (p <.01) and lower levels of reported panic anxiety and phobic avoidance (p <.0001). These data suggest that persistent chest pain in the absence of CAD shares some features with panic disorder, yet differs from panic in key ways as well. The results are discussed in light of the role of anxiety in contributing to symptom labeling.This research was supported by Grant 86G-491 from the American Heart Association, Texas Affiliate, to J.G.B. H.T. is the recipient of USPHS Research Career Development Award K04-HL-0122246.     

Why just turquoise? Remarks on the evolution of color terms

Summary The location of the foci of green and blue in the perceptual color solid indicates that there is space for a derived color term between these two hues. Diachronic and synchronic linguistic studies on color term lexica explain that a term for turquoise is likely to develop into a derived basic color term (in the Kay and McDaniel definition), at present in languages of industrialized countries. In addition to the hypothesis of Zimmer (1982) that türkis (in German) is the result of universal production system for color terms, cultural, social, and psychological factors influence the evolution of new basic color terms.     

Correction to: Effects of reward magnitude and training frequency on the learning rates and memory retention of the Port Jackson shark Heterodontus portusjacksoni

Animal Cognition - In the original publication of the article, the Fig.&nbsp;4 was erroneously published.     

The nature and treatment of stuttering as revealed by fMRI A within- and between-group comparison

This article reviews some of our recent functional magnetic resonance imaging (fMRI) studies of stuttering. Using event-related fMRI experiments, we investigated brain activation during speech production. Results of three studies comparing persons who stutter (PWS) and persons who do not stutter (PWNS) are outlined. Their findings point to a region in the right frontal operculum (RFO) that was consistently implicated in stuttering. During overt reading and before fluency shaping therapy, PWS showed higher and more distributed neuronal activation than PWNS. Immediately after therapy differential activations were even more distributed and left sided. They extended to frontal, temporal, and parietal regions, anterior cingulate, insula, and putamen. These over-activations were slightly reduced and again more right sided two years after therapy. Left frontal deactivations remained stable over two years of observation, and therefore possibly indicate a dysfunction. After therapy, we noted higher activations in persons who stutter moderately than in those who stutter severely. These activations might reflect patterns of compensation. We discuss why these findings suggest that fluency-inducing techniques might synchronize a disturbed signal transmission between auditory, speech motor planning, and motor areas.

Educational objectives: The reader will learn about and be able to: (1) identify regions of brain activations and deactivations specific for PWS; (2) describe brain activation changes induced by fluency shaping therapy; and (3) discuss the correlation between stuttering severity and brain activation.     

NR2B downregulation in a forebrain region required for avian vocal learning is not sufficient to close the sensitive period for song learning

The neural changes that limit the sensitive period for avian song development are unknown, but neurons in a forebrain region critical for song learning, the lMAN, exhibit experience-driven changes in NMDAR subunit expression that could regulate sensitive period closure. Specifically, NR2B levels in lMAN decrease during song acquisition, potentially reducing synaptic plasticity by decreasing NMDAR EPSC duration and/or affecting NMDAR-coupled intracellular cascades. While rearing birds in isolation extends the sensitive period and also delays the developmental changes in NR2B expression and NMDAR physiology, recent work indicates that a transition to faster NMDAR currents does not preclude further song learning. However, NR2B mRNA expression in isolates remains elevated beyond the age at which NMDAR currents shorten, leaving open the possibility that NR2B levels regulate closure of the sensitive period through effects other than those mediated by NMDAR current duration. To determine whether the experience-driven decrease in NR2B expression in lMAN closes the sensitive period, we promoted this change in gene expression either by treating isolation-reared zebra finches briefly with testosterone (T-isolates) or by allowing males limited access to conspecific song (pre-exposed isolates). We then assessed if these birds could acquire song from tutors after the normal close of the sensitive period. Despite a normal decline in NR2B expression, T-isolate and pre-exposed isolate birds learned tutor songs heard from d65-90, while normally reared birds did not. These findings suggest that the normal decline in NR2B expression with lMAN is not sufficient for sensitive period closure.     

Predicate Logics on Display

The paper provides a uniform Gentzen-style proof-theoretic framework for various subsystems of classical predicate logic. In particular, predicate logics obtained by adopting van Behthem's modal perspective on first-order logic are considered. The Gentzen systems for these logics augment Belnap's display logic by introduction rules for the existential and the universal quantifier. These rules for x and x are analogous to the display introduction rules for the modal operators and and do not themselves allow the Barcan formula or its converse to be derived. En route from the minimal modal predicate logic to full first-order logic, axiomatic extensions are captured by purely structural sequent rules.     

Effects of individual aerobic performance on finish time in mountain running

It was hypothesized that for each mountain running competition, there is a certain individual performance level below which running times increase dramatically. The running times of 869 finishers of 3 international mountain running competitions have been analysed. A hyperbolic association was demonstrated between finish times in mountain running competitions and individual performance at the anaerobic threshold (VO2AT(Race)). Due to the non-linear association, there is an increasing effect on both the finish time and the change of finish time with decreasing aerobic performance. In all three competitions, the change of finish time is about 7 times more pronounced in mountain runners with the lowest VO2ATL,, compared to those with the highest values of VO2AT(Race). Both athletes and organizers should keep in mind these effects of decreasing aerobic performance on running times and potentially associated risks.     

A Non-Inferentialist, Anti-Realistic Conception of Logical Truth and Falsity

Anti-realistic conceptions of truth and falsity are usually epistemic or inferentialist. Truth is regarded as knowability, or provability, or warranted assertability, and the falsity of a statement or formula is identified with the truth of its negation. In this paper, a non-inferentialist but nevertheless anti-realistic conception of logical truth and falsity is developed. According to this conception, a formula (or a declarative sentence) A is logically true if and only if no matter what is told about what is told about the truth or falsity of atomic sentences, A always receives the top-element of a certain partial order on non-ontic semantic values as its value. The ordering in question is a told-true order. Analogously, a formula A is logically false just in case no matter what is told about what is told about the truth or falsity of atomic sentences, A always receives the top-element of a certain told-false order as its value. Here, truth and falsity are pari passu, and it is the treatment of truth and falsity as independent of each other that leads to an informational interpretation of these notions in terms of a certain kind of higher-level information.