RNA干扰现象研究获诺贝尔奖的启示

RNA干扰现象是目前生命科学领域的研究热点.由于RNA干扰具有十分重要的理论和应用价值,因此该现象在揭示后仅8年其研究者就获得了诺贝尔生理与医学奖.通过回顾RNA干扰现象的发现历程,可以为今后的科研探索过程提供许多有益的启示.     

社会支持与心血管反应的实验室研究概述

从20世纪70年代起国内外学者开始兴起了对社会支持的研究,而对社会支持与心血管健康的关系研究一直都是社会支持研究领域中的重要课题。本文回顾了社会支持在心血管反应的实验室研究中操作性的定义;实验室研究中社会支持与心血管健康的关系、社会支持对心血管反应作用的影响因素、社会支持的作用机制、社会支持的测量方法及社会支持与心血管反应实验室研究的局限性。     

儿童注意力检测单片机的研制及动态分析指标的试用

儿童注意力的测量途径包括家长或教师评定法、行为观察法、生理检测法及实验室测量法等。在实验室测量法中,持续性操作测试（CPT技术）是主要的测量范式。传统的CPT技术主要应用漏报率和误报率作为评价指标。但是,由于注意不是静态的,而是一个高度动态和波动的过程,漏报率和误报率还不足以反映注意状态的动态变化。近年来的国外研究发现,把注意作为一个动态的现时过程来评估,以儿童在作业中反应状态的波动情况作为新的指标能提供更有价值的信息。本研究以此为依据,开发研制了基于CPT技术的儿童注意力检测单片机SCM-CPT测试仪,在测试结果处理上采用了新的动态分析指标,在98名普通小学生中进行了试用,并为新指标建立了参考性评价标准。     

《易经》与“心理分析”——重访爱诺思

作者以爱诺思的易经研究及富有特色的《周易》译本．作为一个例子,来反映《易经》对心理分析的彤响。     

Attitudes toward maternal serum screening in Chinese women with positive results

Maternal serum screening for fetal Down syndrome has been integrated into routine antenatal care in most clinics in Taiwan. We examined the attitudes toward serum screening and the possible implications in women with positive results. From January to July 1995, 276 women were referred to the Genetic Counseling Clinic, Mackay Memorial Hospital for amniocentesis because of positive screening results, and 214 participated in this study. All women opted for amniocentesis after genetic counseling. Over 40% stated that they made decisions independently after being informed of the serum screening. Need for certainty was the most frequently mentioned reason. Two-thirds believed that serum screening could provide a diagnosis. Almost all women would apply for maternal serum screening for future pregnancies. This study demonstrated that Chinese women need more counseling and autonomy regarding maternal serum screening.     

Transitions in sleep problems from late adolescence to young adulthood: A longitudinal analysis of the effects of peer victimization

Adolescence is a developmental period with high vulnerability to sleep problems. However, research identifying distinct patterns and underlying determinants of sleep problems is scarce. This study investigated discrete subgroups of, changes in, and stability of sleep problems. We also examined whether peer victimization influenced sleep problem subgroups and transitions in patterns of sleep problems from late adolescence to young adulthood. Sex differences in the effects of peer victimization were also explored. In total, 1,455 male and 1,399 female adolescents from northern Taiwan participated in this longitudinal study. Latent transition analysis was used to examine changes in patterns of sleep problems and the effects of peer victimization on these changes. We identified three subgroups of sleep problems in males and two in females, and found that there was a certain level of instability in patterns of sleep problems during the study period. For both sexes, those with greater increases in peer victimization over time were more likely to change from being a good sleeper to a poor sleeper. The effects of peer victimization on baseline status of sleep problems, however, was only significant for males, with those exposed to higher levels of peer victimization more likely to be poor sleepers at baseline. Our findings reveal an important role of peer victimization in predicting transitions in patterns of sleep problems. Intervention programs aimed at decreasing peer victimization may help reduce the development and escalation of sleep problems among adolescents, especially in males.

     

基于团体平衡视角的公立医院改革模式分析

通过分析公立医院改革中的相关利益集团及团体冲突,发现改革的动力主要来自城乡居民和中央政府,阻力主要来自公立医院和地方政府.对公立医院改革的四种模式进行了相关利益集团的利益损益剖析并从团体平衡的视角探究改革政策形成过程的不足、政策内容设计的缺陷.提出政府平衡各团体利益的五种途径:明确改革的价值取向和目标、厘清政府与公立医院的关系、制定游戏规则、协调利益冲突、干预利益格局.     

高血压患者应激反应特点及行为人格的关系研究

为了解高血压患者心血管反应的特征及与健康人群的差异,使用实验和问卷调查的方法对高血压患者和健康居民进行研究。结果显示,两组在任务期和恢复期的心血管反应差异显著（P〈0．05）;病例组的健康实践行为和消极应对方式水平较高,积极应对方式有待提升;健康实践行为和恢复期舒张压呈负相关,积极应对方式和任务期收缩压呈正相关（P〈0...     

意识锚定加工对潜在锚定加工的影响

潜在锚定效应是指阈限下的启动锚定数字导致的锚定效应现象。本研究通过2个实验探讨了意识锚定加工对潜在锚定加工的影响。实验一考察了意识层面的外在锚对潜在锚定效应产生的影响,实验二则进一步探讨了意识层面的自发锚对潜在锚定效应的影响。实验一发现,在不存在外在锚时高锚与低锚的估计有显著性差异;实验二发现,在不存在自发锚时高锚与低锚的估计有显著性差异。研究结果表明,外在锚定加工和自发锚定加工的效应都强于潜在锚定加工。     

父母教养方式对应对方式影响:自尊的中介作用

目的研究初二学生父母教养方式、自尊对应对方式的影响。方法使用父母教养方式问卷、自尊量表、中学生应对方式量表对广州及深圳162名初中二年级学生进行施测。结果 (1)各量表不同因子存在不同的性别效应,父亲惩罚(t=2.737,P<0.01)、父亲拒绝否认(t=2.444,P<0.05)、问题指向应对(t=2.196,P<0.05)。(2)父母情感温暖与自尊、问题指向应对有显著的正相关(r=0.350,r=0.490,P<0.01),父亲偏爱对问题指向应对有显著的正相关(r=0.170,P<0.05);而母亲的拒绝否认和严惩与自尊存在显著的负相关(r=-0.198,r=-0.209,P<0.01),但与情绪指向应对有显著的正相关(r=0.235,r=0.258,P<0.01)。(3)父亲情感温暖(β=0.413,P<0.05)和自尊(β=0.230P<0.05)是问题指向应对方式的预测因子,且自尊是中介因素;母亲严惩(β=0.299,P<0.001)、父亲温暖(β=0.158,P<0.05)对情绪指向应对方式存在显著的预测作用。结论不同教养方式、自尊对不同应对方式存在影响。