Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Infant hypotonia, obesity, hypogenitalism and oligophrenia--new viewpoints on the etiology and symptoms of Prader-Willi syndrome

We present four cases of Prader-Willi syndrome. Two of them have an abnormality of a chromosome 15, the other both show different chromosomal abnormalities. Translocations or deletions were found recently in the bands 15q11/12 in about 60% of the cases of Prader-Willi syndrome. The consequences for diagnosis, symptomatology and genetic counselling of the syndrome are discussed.     

Interpersonal attraction,social identification and psychological group formation

Two perspectives on the nature of the social group and psychological group formation are discussed. The traditional social cohesion approach traces group formation to processes of interpersonal attraction, while the social identity approach defines the group in cognitive terms and considers identification, or self-categorization, to be the mechanism of psychological group formation. On the basis of an experiment by Turner, Sachdev and Hogg (1983) it is hypothesized that interpersonal attraction (positive or negative) is related to group formation only in so far as it enhances intergroup distinctiveness. This hypothesis is experimentally tested in a 2 × 3 (interpersonal liking/disliking per se versus no explicit categorization/random categorization/criterial categorization on the basis of affect) factorial design employing the ‘minimal group’ paradigm. People who like each other and were not explicitly categorized formed a group. This effect was enhanced by criterial categorization but disappeared when categorization was random. Although the results do not support the hypothesis, they are not explicable in social cohesion terms. A social identity explanation is furnished—attraction influences group formation by acting, under certain specifiable conditions, as a cognitive criterion for common category membership. This explanation is located in current theorizing and is proposed as part of a reconceptualization of the relationship between interpersonal attraction and group formation.     

Prejudice,categorization and particularization: From a perceptual to a rhetorical approach

This paper seeks to offer an alternative approach to the study of prejudice than that based upon the notion of categorization which is currently influential in cognitive social psychology. It is argued that the categorization approach assumes the inevitability of prejudice and ignores the issue of tolerance. The assumptions of the categorization approach are criticized, and it is suggested that, by focusing on categorization as a cognitive process, it has overlooked an opposing process—that of particularization. The result has been a rather mechanical and bureaucratic model of cognition. A less mechanical view is possible if the relations between the two processes of categorization and particularization are considered from a rhetorical perspective, which examines the argumentative nature of thought. For theoretical and empirical reasons, this perspective does not equate prejudiced thinking with rigid categorization; instead a rhetorical approach permits a distinction between prejudice and tolerance on the basis of content, rather than form, and thereby avoids assuming the inevitability of prejudice.     

Changes in self-stimulatory behaviors with treatment

For four of six autistic children who underwent intensive behavioral treatment, the nature of their self-stimulatory behavior changed from initial lowlevel motor behaviors (such as rocking, spinning, twirling) to differing kinds of higher-level behaviors (such as lining of objects, echolalic speech, and preoccupation with spelling and numerical values). The children who changed to the highest levels of self-stimulatory behavior also showed the largest gains in treatment (as determined by IQ scores, school placement, etc.). The changes in self-stimulatory behaviors were attributed to the intense teaching of appropriate social behaviors and the explicit therapeutic suppression of low-level, self-stimulatory behaviors. The long-term therapeutic effects of changing from lower-to higher-level forms of self-stimulatory behavior were discussed.This study was supported by a grant from the National Institute of Mental Health (grant MH 11440). We want to express our thanks to the parents who allowed us to study their children. We gratefully acknowledge the assistance of Maria Audero with the design of the weighted measure, and Tracee Parker with the collection of the data.     

Physical self-efficacy and actualization

In his theorizing about self-actualization, Maslow speculated that physical ability and physical self-confidence were two aspects of cooperative dominance which were associated positively with actualization. These aspects of dominance bear close resemblance to the Perceived Physical Ability (PPA) and the Physical Self-Presentation Confidence (PSPC) dimensions of the Physical Self-Efficacy (PSE) Inventory. Accordingly, the PPA and PSPC scores of undergraduate men and women were correlated with their scores on the Personal Orientation Inventory (POI), a popular measure of actualization, to test Maslow's hypotheses. The results showed that, contrary to Maslow's claims, PPA is not a positive correlate of self-actualization. However, strong support was found for Maslow's contention that high-PSPC individuals are more likely to be actualizing than low-PSPC people. Also, Maslow's hypothesis that actualizers are high in global sensation seeking (SS) was tested. The data indicated that only male actualizers were high in various aspects of SS, but female actualizers were not. Multiple regression analyses revealed further that both SS and PSPC are primary contributors to POI for men, but only PSPC contributes significantly to POI for women. Discussion focused on the reasons why research findings showing that increases in physical fitness lead to increases in self-esteem cannot be used to support the view that physical fitness and actualization are linked positively.     

The evolution of a therapy group for vietnam veterans on a general psychiatry unit

The evolution of a therapy group for hospitalized Vietnam veterans with post-traumatic stress disorder (PTSD) and related symptomatology is described. The literature on group treatment for this population is briefly reviewed and discussed in relation to an inpatient psychiatry setting. The prevailing conditions at the time of group inception are recalled along with the initial goals of the therapeutic intervention. Problems encountered are also discussed, along with the changes made in response to these identified difficulties. The results of three and one-half years of experience with this group are described in detail.The authors would like to thank Cynthia Sturm, Ph.D. for her helpful editorial assistance.     

Recommended Regulation of Common Drugs: The Relative Influence of Facts vs. Labels

The present study examined the hypothesis that individuals are more influenced by a drug name than by the side effects associated with that drug when making recommendations regarding regulation. Subjects recommended the amount of regulation that should exist for eight drugs ranging from aspirin to LSD. One third of the subjects were asked to make recommendations based only on the drug name. Another third made recommendations based only on the facts associated with the drugs (i.e., side effects, symptoms). A final third made recommendations based on both facts and the drug name. Results indicated that, when given only the facts, subjects' recommendations deviated greatly from the actual regulation of the drugs but that the facts were ignored if subjects knew the name of the drug. These results suggest that critical information may be ignored when decisions are made about drug regulation. The implications for self-regulated drug use are discussed.