Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia

Exposure to high altitude is known to cause impairment in cognitive functions in sojourners. The molecular events leading to this behavioral manifestation, however, still remain an enigma. The present study aims at exploring the nature of memory impairment occurring on chronic exposure to hypobaric hypoxia and the possible role of glutamate in mediating it. Increased ionotropic receptor stimulation by glutamate under hypobaric hypoxic conditions could lead to calcium mediated excitotoxic cell death resulting in impaired cognitive functions. Since glutamate is cleared from the synapse by the Glial Glutamate Transporter, upregulation of the transporter can be a good strategy in preventing excitotoxic cell death. Considering previous reports on upregulation of the expression of Glial Glutamate Transporter on ceftriaxone administration, the therapeutic potential of ceftriaxone in ameliorating hypobaric hypoxia induced memory impairment was investigated in male Sprague Dawley rats. Exposure to hypobaric hypoxia equivalent to an altitude of 7600 m for 14 days lead to oxidative stress, chromatin condensation and neuronal degeneration in the hippocampus. This was accompanied by delayed memory retrieval as evident from increased latency and pathlength in Morris Water Maze. Administration of ceftriaxone at a dose of 200 mg/kg for 7 days and 14 days during the exposure on the other hand improved the performance of rats in the water maze along with decreased oxidative stress and enhanced neuronal survival when compared to hypoxic group without drug administration. An increased expression of Glial Glutamate Transporter was also observed following drug administration indicating faster clearance of glutamate from the synapse. The present study not only brings to light the effect of longer duration of exposure to hypobaric hypoxia on the memory functions, but also indicates the pivotal role played by glutamate in mediating excitotoxic neuronal degeneration at high altitude. The therapeutic potential of ceftriaxone in providing neuroprotection in excitotoxic conditions by increasing Glial Glutamate Transporter expression and thereby enhancing glutamate uptake from the synapse has also been explored.     

The relative effects of competence and likability on interpersonal attraction

Undergraduate students in Singapore (N = 80) learned about the competence (low vs. high) and likability (low vs. high) of a future interaction partner and indicated their attraction toward that stranger. The effect of likability was two times as large as that of competence. Because of the additive effects of the two manipulated factors on attraction, the authors interpreted the preference for lovable fools over competent jerks as an outcome of a generalized supremacy of likability over competence.     

Microswitch-based programs for persons with multiple disabilities: an overview of some recent developments

Persons with multiple disabilities are often unable to interact with their environment due to their limited response repertoire. Microswitch programs are designed to help them control environmental events, generally preferred stimulation, through simple (feasible) responses. To make microswitch programs a more widely usable and relevant resource for intervention with these persons, a number of new developments were pursued in recent years. This paper examines three of those developments as specifically addressed in our research activity, namely, (a) assessment of new, nontypical responses and matching microswitches, (b) fostering of multiple responses and exercise of choice, and (c) targeting of habilitative and clinical (therapeutic) objectives. The encouraging outcomes of these developments are reviewed in relation to their potentially wide implications for daily practice and the need of additional developments in the area.     

Views of Employee Participation, Higher Order Needs, Altruism, Pride in Craftsmanship, and Collectivism: Implications for Organizational Practice and Public Policy

Using a sample of 749 individuals, we examine the correlation of views of employee participation and higher order needs, altruism, pride in craftsmanship, and collectivism. Structural equation modeling (accounting for measurement errors) shows that views of employee participation are correlated positively with higher order needs, altruism, pride in craftsmanship, and collectivism. Our model also shows equivalency across 3 different age groups. Implications of our results for organizational practice and public policy are discussed.     

The Process of Transcending a Traumatic Childhood

This study used a qualitative, exploratory approach to develop a conceptual framework that illustrated the process by which spirituality emerged as one of the processes that helped people transcend a traumatic childhood. Ninety people described how they survived and transcended the difficult time. This article outlines the stages of the developmental process that culminated for many in a deeper spiritual awareness and how this helped them in their process of transcending. These findings have implications for marriage and family therapists, clergy, and others in the helping professions in providing therapy, resources, and support for those who have experienced difficult childhoods.     

What matters most? The relative role of mentoring and career capital in career success

This study used a career capital framework to compare the relative role of mentoring and three other forms of career capital (human, agentic, and developmental network capital) in predicting career success. Using a three-wave longitudinal design we found that mentoring added value, above and beyond the other forms of career capital, in predicting promotions and advancement expectations. However, although mentoring mattered for career success, it represented just a part of a constellation of career resources that are embedded within individuals and their relationships. Implications for future research are discussed.     

Interpersonal trust and organizational citizenship behavior

This study investigates the relationship between certain individual level determinants of interpersonal trust and its impact on organizational citizenship behavior. The participants (N=303) were top, middle, and lower level executives from manufacturing and services sectors. The results indicate that interaction frequency, consistency, and competence are significant predictors of interpersonal trust. Interpersonal trust is positively associated with organizational citizenship behavior, and it also partially mediated the relationship between individual level factors and organizational citizenship behavior. The results imply that the development of trust at the interpersonal level may be used as a strategy to motivate the employees to engage in extra role behaviors to ensure improved individual and organizational performance.