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61.
Biphasic ERK1/2 activation in both the hippocampus and amygdala may reveal a system consolidation of contextual fear memory 总被引:1,自引:0,他引:1
Trifilieff P Calandreau L Herry C Mons N Micheau J 《Neurobiology of learning and memory》2007,88(4):424-434
There is accumulating evidences to suggest that memory consolidation in some conditions involves two waves of neuronal plastic change. Using two fear conditioning procedures in male C57BL/6J mice, we have recently shown that consolidation of the foreground contextual fear memory required two waves of ERK1/2 activation in hippocampal CA1, while consolidation of cue conditioning was only associated with the early phase of activation. The present experiment further showed that this bi-phasic pattern of ERK1/2 activation was not restricted to hippocampal CA1, but could also be observed in other fear memory-related brain areas. The unpaired conditioning procedure (context in foreground) induced two waves of ERK1/2 activation in hippocampal CA1 and CA3, as well as in the LA and BLA nuclei of the amygdala. In contrast, the paired conditioning procedure (context in background) led to a transient early phase only in hippocampal CA1 and LA. In addition, ERK1/2 phosphorylation in the hippocampus was found to correlate with that in the amygdala nuclei specifically after the unpaired procedure. Taken together, our data suggest that the observed biphasic pattern of neuronal plastic events may reflect the interplay between hippocampal and amygdala activity-dependent plasticity critical for the system consolidation of contextual fear memory. 相似文献
62.
Functional neuroimaging studies of autobiographical memory have grown dramatically in recent years. These studies are important because they can investigate the neural correlates of processes that are difficult to study using laboratory stimuli, including: (i) complex constructive processes, (ii) recollective qualities of emotion and vividness, and (iii) remote memory retrieval. Constructing autobiographical memories involves search, monitoring and self-referential processes that are associated with activity in separable prefrontal regions. The contributions of emotion and vividness have been linked to the amygdala and visual cortex respectively. Finally, there is evidence that recent and remote autobiographical memories might activate the hippocampus equally, which has implications for memory-consolidation theories. The rapid development of innovative methods for eliciting personal memories in the scanner provides the opportunity to delve into the functional neuroanatomy of our personal past. 相似文献
63.
Frederick L. Philippe Robert J. Vallerand Isabelle Richer ÉVelyne Vallières Jacques Bergeron 《Journal of applied social psychology》2009,39(12):3020-3043
The purpose of the present research was to investigate the relationship between passion for driving and aggressive driving behavior in 3 studies. Study 1 examined the association between passion and aggressive driving behavior in a sample of undergraduate students. Results showed that an obsessive passion for driving was associated with aggressive driving behavior, while harmonious passion was not. Study 2 replicated these results with an ecologically valid sample of community‐dwelling drivers. Finally, Study 3 replicated the results obtained in Studies 1 and 2 in a laboratory setting using a driving simulator under controlled frustrating driving situations with judges' assessment of aggressive driving behavior. Study 3 also showed that the emotion of anger mediated the obsessive‐passion/aggressive‐driving‐behavior relationship. 相似文献
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Lubomir Lamy Jacques Fischer-Lokou Nicolas Guéguen 《Current psychology (New Brunswick, N.J.)》2009,28(3):202-209
This study tested the effect of semantically-induced thoughts of love on chivalrous helping. A field setting of four hundred
and one participants was divided into two groups. One group was interviewed and asked to retrieve the memory of a love episode,
and the second group, the control group, was asked to retrieve a piece of music that they love. The two groups encountered
another confederate, who inadvertently lost a stack of compact discs when they neared each other. The results demonstrated
that participants were more helpful when they were male, when the person in need of help was female, and when they were induced
to retrieve the memory of a love episode. 相似文献
66.
Categorical flexibility in preschoolers: contributions of conceptual knowledge and executive control
The current study evaluated the relative roles of conceptual knowledge and executive control on the development of categorical flexibility, the ability to switch between simultaneously available but conflicting categorical representations of an object. Experiment 1 assessed conceptual knowledge and executive control together; Experiment 2 differentiated conceptual knowledge from costly executive processes. In Experiment 1, 3‐ to 5‐year‐olds were given a three‐choice (taxonomic, thematic, and nonassociate) match‐to‐sample task and asked to match two associates. In Experiment 2, same‐aged children were assessed on another match‐to‐sample task that reduced executive costs by presenting thematic and taxonomic associates on separate trials. By comparing performance across tasks, age‐related changes resulting from conceptual knowledge and executive control indicated that conceptual knowledge of superordinate relations showed gains between 3 and 4 years, whereas gains in executive control were seen between 4 and 5 years, suggesting a décalage in the development of conceptual and executive processes underlying categorical flexibility. 相似文献
67.
The aim of this study was to measure the pattern of hand preferences for pointing gestures as a function of object‐manipulation handedness in 123 infants and toddlers (10–40 months). The results showed that not only right‐handers but also left‐handers and ambidextrous participants tended to use their right hand for pointing. There was a significant correlation between manual preferences and pointing lateralization. Further analyses showed that the correlation between these two indexes was at its strongest during two key phases of language development (i.e. vocabulary spurt and syntax improvement) and weakened to become nonsignificant in the interim. These findings support the view that humans have a specialized area for communicative gestures and language in the left cerebral hemisphere that may be independent of the system controlling the purely motor functions of hand use. 相似文献
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69.
Fabrice Perch Jacques Young Paul Robel Neal G. Simon Marc Haug 《Aggressive behavior》2001,27(2):130-138
The neurosteroid dehydroepiandrosterone (DHEA) is a powerful inhibitor of aggression in murine models when given for 15 days and potentially may be useful in the management of inappropriate human aggression. Although the biosynthesis and metabolism of DHEA have been described, little is known about the potential effect of the steroidal environment during sexual differentiation on the subsequent response to DHEA. Whether prenatal androgen exposure influences the subsequent response to DHEA was assessed by comparing the effect of DHEA (80 μg/d) on aggression in female offspring where dams were treated with 1, 10, or 100 μg of testosterone (T) on days 15 to 18 of gestation (Experiment I) or that developed in different uterine positions (Experiment II). The results showed that DHEA decreased attack behavior in general and that the 100‐μg prenatal T treatments enhanced the antiaggressive effect of this neurosteroid. Neither the lower doses of exogenously administered T nor the uterine position led to an enhanced response to DHEA. In addition, whether DHEA produced changes in social and nonsocial activities was examined. In the 100‐μg T females, DHEA increased the duration of the former and decreased the frequency and duration of the latter, indicating that it was not a general decrement in behavioral expression that mediated the enhanced response to the antiaggressive effect of DHEA. In the second experiment, DHEA treatment led to increased frequencies of social nonaggressive and nonsocial activities. However, the uterine positions × treatment interactions were not significant, demonstrating that contiguity to male fetuses did not differentially affect the response to DHEA. Aggr. Behav. 27:130–138, 2001. © 2001 Wiley‐Liss, Inc. 相似文献
70.