在医学伦理学教学中融入医学法制教育的探索

道德与法律在临床医疗实践中的碰撞、冲突给医学生带来许多困惑,通过医学道德规范与医学法律规范对比和典型案例剖析,在医学伦理学教学中融入医学法制教育,能够澄清医学生模糊混乱的认识,引导他们正确对待医学道德与医学法律的关系,深化医学伦理学教学内容,提升教学效果.     

多发性骨髓瘤的分子生物学特性及靶向治疗对策

近十年来,关于骨髓瘤细胞的分子生物学研究取得了很大的进展.骨髓瘤细胞通过激活多种信号途径以及与蛋白折叠反应相关的信号通路,抑制正常浆细胞的生长.一些基因和分子改变与临床表现相关并成为治疗的潜在靶点.认识骨髓瘤细胞的分子生物学特性对于采取合理的治疗措施、改善患者的预后至关重要.     

浅析幽门螺杆菌研究过程中的科研创新

幽门螺杆菌(Hp)是一种古老细菌,但是人们直到近年才发现并确定其与多种胃肠道疾病相关,如胃炎、消化性溃疡、胃癌等;在对Hp的科研创新中经历了许多的成功与挫折,如Hp的发现过程中的科研创新、思维变化;通过从临床流行病学到基础研究揭示胃癌与幽门螺杆菌的关系;Hp的治疗中所涉及的伦理,治疗策略问题;Hp在人类迁移的研究过程的意义,以及疫苗的研究过程中所面临的挑战与机遇等.本文通过回顾Hp的研究过程,简单揭示幽门螺杆菌科研过程中的科研思维变化.     

Event-related brain potentials: report order and task switch on multidimensional stimuli identification

An experiment was conducted to evaluate the effect of order of reporting stimulus dimension in multidimensional stimulus identification using a switch-task paradigm. Participants were required to identify each two-dimensional symbol by pushing the corresponding buttons on the keypad on which there were two columns representing the two dimensions, part and shape. The two orders of report were Order Part/Shape and Order Shape/Part. There was a task cue prior to each presentation of a symbol indicating the particular report order the participants should perform. The cue changed randomly. Both behavioral data and event-related potentials were recorded from 12 college students. Analysis of behavioral data showed switch cost indicated by increase in response time was greater for Order Shape/Part, a less appropriate order of reporting dimensional values, than Order Part/Shape (88 msec. vs 9 msec. for response time for the first stimulus dimension; 96 msec. vs -1 msec. for response time total). Neural activities under Order Shape/Part and Order Part/Shape were different, and it seems plausible that participants put more effort into selection and showed more related semantic activation in Order Shape/Part than in Order Part/ Shape which fits the Chinese adjective-then-noun language habit.     

Hemispheric competition in left-handers on bimanual reaction time tasks

The authors examined possible differences in left- and right-handers on bimanual reaction times to centralized visual stimuli. Eighty participants (n = 40 in each group of left- and right-handers) were tested on unimanual and bimanual reaction time (RT) tasks. Consistently across the 2 groups, the dominant-hand RT was faster, on average, than the nondominant-hand RT, and unimanual RTs were faster than bimanual RTs. However, RT differences between hands revealed a higher percentage of dominant-hand-led trials in right-handers than in left-handers, despite similar absolute RT differences in the 2 groups. On the basis of those findings, the authors conclude that hand dominance does not generally determine which hand leads in a bimanual task and that left-handers have stronger between-hemisphere competition than right-handers do.     

A structural model of acculturation and mental health status among Chinese Americans

This study examined the role of acculturation and its direct and indirect impact on depressive symptom severity through various correlates, including socioeconomic status (SES), stress, social support, personality negativity, and physical health perception. Using structural equation modeling, the proposed model was tested with 983 employed Chinese Americans from a representative community sample, the majority of whom were immigrants. The results demonstrated that acculturation, correlated with SES, contributed to depressive symptom severity only through indirect pathways. Higher acculturation was found associated with higher stress that in turn contributed to more elevated depressive symptoms. On the other hand, higher acculturation was also found strongly correlated with higher SES, which was associated with lower depressive symptoms directly or indirectly through several mediators. Better support, lower personality negativity, better health perception, and lower stress were found mediating the relationship between higher SES and lower depressive symptom severity. The simultaneous multigroup analysis showed that the final model was comparable for both men and women with very few differences.     

Investigating the visual span in comparative search: the effects of task difficulty and divided attention

In three experiments, participants' visual span was measured in a comparative visual search task in which they had to detect a local match or mismatch between two displays presented side by side. Experiment 1 manipulated the difficulty of the comparative visual search task by contrasting a mismatch detection task with a substantially more difficult match detection task. In Experiment 2, participants were tested in a single-task condition involving only the visual task and a dual-task condition in which they concurrently performed an auditory task. Finally, in Experiment 3, participants performed two dual-task conditions, which differed in the difficulty of the concurrent auditory task. Both the comparative search task difficulty (Experiment 1) and the divided attention manipulation (Experiments 2 and 3) produced strong effects on visual span size.     

Jungian Analysis of the Chinese Mythological Image of Sun Wukong

This paper examines the symbolism of the cultural image Sun Wukong (the Monkey King), a Chinese legendary hero, and how it influenced an eight-year-old boy’s psychic development. Through an analysis of Sun Wukong’s life from his birth to attaining Buddhahood, a three-phase healing process is identified in Sun Wukong’s tale and the psychotherapeutic process: “naming and initiating,” “nurturing and taming,” and “transforming and transcending,” proposed by Dr. Heyong Shen. Sandplay visually highlighted these key clinical changes in conscious awareness and developmental behaviour influencing the boy’s individuation process. Images found either in cultural traditions or spontaneously emerging from the unconscious in individuals are of significance in human life, offering pathways to psychic healing and development. Further, myths and cultural resources used in clinical work demonstrate that having cultural competency is invaluable in Jungian analysis. Pathogenic and health-maintenance factors of culture can be explored in future clinical practice and research.     

儿童运动行距预测能力的发展及影响因素

采用计算机软件控制实验,以三种不同运动速度、四种不同运动行距组合呈现的光点运动为刺激物,每次光点在暴露运动一段行程后进入遮蔽,要求儿童判断光点到达目标位置时按键反应。主要结果表明：（１）儿童运动行距预测能力的发展表现为５─８岁和１２─１９岁两个加速期及８─１２岁一个过渡期的发展模式。但在过渡期内,儿童的预测误差偏向有显著变化;（２）客体运动速度对儿童运动行距预测操作精度有显著影响,慢速下精度较高;（３）客体运动行距、被试性别并不影响儿童的行距预测操作;（４）５岁、１２岁与１９岁儿童多倾向于超前反应。     

抑郁者操作任务中目标设立与自我评价的特点

参加研究的被试包括：抑郁性神经症组（２０人）,抑郁症组（１３人）,正常对照组（２９人）。所有被试在完成独粒钻石棋作业的前后对其作业目标进行了估计,并在作业后对操作的满意程度进行了评价,对影响操作者的因素进行了归因,研究所得到的主要结果为（１）抑郁者在操作任务前的目标设立与正常人或抑郁者相似。（２）实际作业成绩与效能感得分相关,（３）抑郁症,抑郁性神经症相被试消极的自我归因倾向明显高于正常组。