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201.
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment 总被引:1,自引:0,他引:1 下载免费PDF全文
Shum FW Wu LJ Zhao MG Toyoda H Xu H Ren M Pinaud R Ko SW Lee YS Kaang BK Zhuo M 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(4):304-312
Exposure to an enriched environment (EE) has been shown to induce cortical plasticity. Considerable amount of research is focused on the effects of EE in the hippocampus; however, effects of EE on other brain regions and the mechanisms involved are not well known. To investigate this, we induced cortical plasticity by placing mice in an EE for one month and measured the effects of EE in the anterior cingulate cortex (ACC). Here, we show that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulate long-term potentiation (LTP) and decreased cingulate long-term depression (LTD). The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged. Furthermore, behavioral experiments show that these mice exposed to EE demonstrate enhanced responses to acute and long-term inflammation. Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation. 相似文献
202.
203.
基于“医−患−机”分析框架,医疗机器人的不断发展面临主体资质复杂、责任认定困难等责任伦理风险,医患关系重构、医患信任危机等医患伦理风险,数据质量与数据隐私等数据伦理风险,算法安全与算法偏见等算法伦理风险以及医疗资源分配正义风险。医疗机器人的伦理治理要以医学伦理和机器人伦理准则为依据,建立多元伦理治理体制,推动学术共同体的构建,探索自愿型、调节型与管制型等伦理治理工具的组合运用,加快医疗机器人伦理治理的法治化发展。
相似文献204.
The role of ambiguity tolerance in career decision making was examined in a sample of college students (n = 275). Three hypotheses were proposed regarding the direct prediction of ambiguity tolerance on career indecision, the indirect prediction of ambiguity tolerance on career indecision through environmental and self explorations, and the moderation effect of ambiguity tolerance on the link of environmental and self explorations with career indecision. Results supported the significance of ambiguity tolerance with respect to career indecision, finding that it directly predicted general indecisiveness, dysfunctional beliefs, lack of information, and inconsistent information, and moderated the prediction of environmental exploration on inconsistent information. The implications of this study are discussed and suggestions for future research are provided. 相似文献
205.
研究目的在于验证班主任教师的班级管理效能感对学生学习态度等方面有正向预测作用及其对学生学业效能和学习态度间的关系具有调节作用的假设。通过对109个班级的班主任教师和3066名三到六年级的小学生进行问卷调查,多层线性模型(HLM)分析结果表明:(1)在控制学生性别影响时,学生的学习态度、学习方法和学习技术存在显著的班级水平差异;学生学业效能对学生学习态度、学习方法和学习技术有显著的预测作用,且这一影响强度存在显著的班级水平差异。(2)在控制教师所教年级的影响下,班主任教师班级管理效能的高低对学生学习态度、学习方法和学习技术的班级差异具有显著的预测作用,班主任教师班级管理效能感高的班级,学生学习态度越积极;(3)班主任教师班级管理效能感对学生学业效能与学生学习态度和学习方法之间的关系具有显著的调节作用,班主任教师班级管理效能感越高,学生学业效能对学习态度和学习方法的影响越弱,反之班主任教师管理效能感低的班级,学生学业效能感对学习态度的影响较大。 相似文献
206.
基于笔记文本的内容分析法系统地考察了大学生的问题意识和笔记策略状况,以及二者与学业成绩的关系。结果发现:(1)基于笔记文本的内容分析法能有效地了解大学生的问题意识状况,以及笔记策略的使用种类、频次和实际水平;(2)大学生笔记策略种类丰富且存在优势笔记策略,但问题意识相对薄弱;在问题意识、笔记策略和学业成绩上均存在显著的水平和性别差异。(3)大学生的问题意识、策略数量、策略频次与学业成绩之间呈显著正相关,问题意识对学业成绩的影响以笔记策略数量为中介。 相似文献
207.
20世纪初,太虚大师等人倡导的"人间佛教"运动警醒了明清至民国陷于腐败、堕落的中国佛教,开始了近一个世纪的"人间佛教"运动.进入新世纪,回头分析"人间佛教"的发展,可以从中吸取很多经验,同时也可发现当中存在的问题.笔者提出"都市佛教"理念,以期通过它为"人间佛教"的发展瓶颈找到解决之策. 相似文献
208.
126 leaders and 624 employees were sampled to test the relationship between sources of motivation and conflict management styles of leaders and how these variables influence effectiveness of leadership. Five sources of motivation measured by the Motivation Sources Inventory were tested-intrinsic process, instrumental, self-concept external, self-concept internal, and goal internalization. These sources of work motivation were associated with Rahim's modes of interpersonal conflict management-dominating, avoiding, obliging, complying, and integrating-and to perceived leadership effectiveness. A structural equation model tested leaders' conflict management styles and leadership effectiveness based upon different sources of work motivation. The model explained variance for obliging (65%), dominating (79%), avoiding (76%), and compromising (68%), but explained little variance for integrating (7%). The model explained only 28% of the variance in leader effectiveness. 相似文献
209.
Understanding the object benefit in visual short-term memory: the roles of feature proximity and connectedness 总被引:2,自引:0,他引:2
Xu Y 《Perception & psychophysics》2006,68(5):815-828
Past research has identified visual objects as the units of information processing in visual short-term memory (VSTM) and has shown that two features from the same object can be remembered in VSTM as well (or almost as well) as one feature of that object and are much better remembered than the same two features from two spatially separated objects. It is not clear, however, what drives this object benefit in VSTM. Is it the shared spatial location (proximity), the connectedness among features of an object, or both? In six change detection experiments, both location/proximity and connectedness were found to be crucial in determining the magnitude of the object benefit in VSTM. Together, these results indicate that location/proximity and connectedness are essential elements in defining a coherent visual object representation in VSTM. 相似文献
210.
Preschoolers' theory-of-mind development follows a similar age trajectory across many cultures. To determine whether these similarities are related to similar underlying ontogenetic processes, we examined whether the relation between theory of mind and executive function commonly found among U.S. preschoolers is also present among Chinese preschoolers. Preschoolers from Beijing, China (N= 109), were administered theory-of-mind and executive-functioning tasks, and their performance was compared with that of a previously studied sample of U.S. preschoolers (N= 107). The Chinese preschoolers outperformed their U.S. counterparts on all measures of executive functioning, but were not similarly advanced in theory-of-mind reasoning. Nonetheless, individual differences in executive functioning predicted theory of mind for children in both cultures. Thus, the relation between executive functioning and theory of mind is robust across two disparate cultures. These findings shed light on why executive functioning is important for theory-of-mind development. 相似文献