细胞凋亡与疾病的治疗

２０年前,人们就开始注意细胞凋亡现象,但由于当时人们细胞信号传导及真核基因调控所知甚少,因此只能孤立地看待“细胞凋亡”,２０年后,人们重新认识“细胞凋亡”发现它是一种生理性死亡,是通过一种细胞固有的ＤＮＡ编码的自杀程序,系统思维方法,使人们将凋亡与当今疾病的治疗联系起来,科学家们一方面通过诱导细胞凋亡来达到治疗肿瘤目的,另一方面又通过阻止这种细胞凋亡来治疗艾滋病,我们从中看到事物的辨证统一,充分体     

沃尔夫假说的新证据:范畴内和范畴间颜色辨别难度相同时语言范畴也会影响注意前颜色知觉

该研究探讨了当范畴内和范畴间颜色的辨别难度相同时,语言范畴是否会影响注意前颜色知觉。实验中,采用渐变且相邻者差别阈限数相当的A、B、C、D四种颜色（前两者为绿色,后两者为蓝色）为刺激材料,并让被试接受视觉Oddball脑电测试。脑电测试分视野给被试呈现标准刺激,以及与标准刺激属同一语言范畴（即颜色词绿色或蓝色）或不同语言范畴的偏差刺激。结果发现：在左视野呈现时,范畴内偏差刺激比范畴间偏差刺激诱发了边缘显著更大的视觉失匹配负波（vMMN）,在右视野呈现时,两类偏差刺激诱发的vMMN无显著差异;范畴内偏差刺激在不同视野呈现时诱发的vMMN无显著差异,范畴间偏差刺激则在右视野呈现时诱发了显著更大的vMMN。这一结果表明,当范畴内和范畴间颜色的辨别难度相同时,语言范畴也会影响早期的、注意前颜色知觉,支持了沃尔夫假说。     

The benefits of need satisfaction depend on their relative importance for people with a unidimensional identity: an idiographic analysis

Motivation and Emotion - Self-determination theory proposes that the satisfaction of basic psychological needs is equally beneficial for everyone – the Universal Hypothesis. Equally, there...     

Managing multiple chronic conditions in Singapore – Exploring the perspectives and experiences of family caregivers of patients with diabetes and end stage renal disease on haemodialysis

Objective: Diabetes mellitus (DM) is the commonest cause of end stage renal disease (ESRD). Despite increasing DM-ESRD prevalence and high dependency on care, there is a lack of literature on DM-ESRD caregivers. We sought to explore the perspectives and experiences of caregivers of patients with DM undergoing haemodialysis in Singapore.

Design: This study employed an exploratory, qualitative design comprising in-depth interviews with caregivers of DM-ESRD patients.

Methods: Semi-structured interviews were conducted with a sample of 20 family caregivers (54.2 ± 12.6 years; 75% female) of DM-ESRD patients. Data were analysed using Thematic Analysis.

Results: Key caregiving challenges identified were managing diet, care recipients’ emotions and mobility dependence. Patients’ emotional reactions caused interpersonal conflicts and hindered treatment management. Difficulties in dietary management were linked to patients’ erratic appetite, caregivers’ lack/poor understanding of the dietary guidelines and caregivers’ low perceived competence. Limited resources in terms of social support and finances were also noted. Physical and psychological well-being and employment were adversely affected by caregiving role.

Conclusion: This study highlights distinctive aspects of the DM-ESRD caregiving experience, which impact on caregivers’ health and challenge care. Disease management programmes should be expanded to support caregivers in dealing with multimorbidity.     

Regional gray matter volume mediates the relationship between family socioeconomic status and depression-related trait in a young healthy sample

Socioeconomic status (SES) is a complex phenomenon that is predicted by a broad spectrum of variables and is often conceptualized as a combination of financial, occupational, and educational influences. SES is associated with symptoms of depression and depression-related personality traits. Many studies have focused on the relationship between SES and depression symptoms in clinical subjects; however, there are few studies of the neural basis of the relationship between SES and depression-related personality traits in nonclinical subjects. Thus, in the present study, we studied the neural basis of the relationship between SES and depression-related traits. The first step was to use voxel-based morphometry (VBM) to investigate the neuroanatomical basis underlying family SES in a large sample of healthy subjects. We found a significant negative correlation between family SES and the medial prefrontal cortex (mPFC) that extending to the anterior cingulate cortex (ACC). Then, the mediation analysis revealed that the correlation between family SES, especially family income, and depression-related traits were mediated by the region of the mPFC that extending to the ACC volume. These findings suggest that the family income may play more important role in driving depression-related traits than that of parental education. They also suggest that the mPFC extension to the ACC may play an important role in the correlation between familial SES, especially with respect to family income and the depression-related traits.     

基于通道的内源性注意对声音诱发闪光错觉的影响

声音诱发闪光错觉是指当视觉闪光伴随不相等数量的听觉声音在100 ms内相继或同时呈现时, 个体会错觉性地知觉到视觉闪光的个数与听觉声音的数量相等。研究采用经典的声音诱发闪光错觉范式, 将注意以内源性的方式指向视觉通道或者听觉通道, 考察了基于通道的内源性注意对声音诱发闪光错觉的影响。结果发现, 当注意内源性地指向视觉通道时, 相对于基线条件, 裂变错觉的量显著减小; 当注意内源性地指向听觉通道时, 相对于基线条件, 裂变错觉的量存在增大的趋势。说明了基于通道的内源性注意可以影响声音诱发闪光错觉中的裂变错觉, 但不影响融合错觉。     

CHRM3基因与孤独症谱系障碍

孤独症谱系障碍是一类具有遗传基础的儿童发展障碍疾病。近些年, 研究者们从分子病理学层面发现中枢胆碱能神经系统异常与孤独症患者认知和行为异常存在相关性。尸检研究、临床案例、动物模型研究均发现毒蕈碱型(M型)乙酰胆碱受体异常和孤独症的发生有着密切的关系。在以小鼠为模型的行为学研究中, 编码毒蕈碱型乙酰胆碱受体Ⅲ亚型的CHRM3基因突变会导致小鼠出现认知障碍、刻板行为等孤独症样表现。深入了解CHRM3基因的功能将能够帮助研究者进一步解释孤独症的相关行为特征, 为孤独症儿童教育方案的制定提供新的思路和方法。     

预期错误在复合恐惧记忆提取消退中的作用

基于记忆再巩固理论的提取消退范式被证明是一种有效和颇有前景的消除不良记忆的方法。本研究将预期错误(Prediction Error, PE)应用于提取消退范式中, 采用多感官复合刺激模型(声音 + 图片)作为条件刺激, 以皮电反应作为恐惧反应指标, 考察在提取阶段不同的预期错误设置(无PE、单个负性PE、单个正性PE和多重PE)对条件性恐惧记忆提取消退效果有何差异。结果表明：无PE组和多重PE组出现了恐惧的自发恢复和重建效应, 而负性PE组和正性PE组均没有出现恐惧的自发恢复和重建效应。说明了在对复合恐惧记忆进行提取消退时, 提取阶段适当的PE才能使记忆进入再巩固过程, 随后传统消退达到抑制恐惧返回效果, 提取阶段没有PE或PE量过多都不能达到恐惧消退效果。