黑色素瘤内科治疗的新进展

黑色素瘤的生物学知识在对这种疾病的药物研发上发挥了重要的作用。在过去的10年中,黑色素瘤进入了靶向治疗的新时代,这种疾病的治疗方法发生了革命性的改变。从2011年,已有4种新药被批准应用于转移性黑色素瘤的治疗,包括：伊匹单抗、维罗菲尼、达拉菲尼和曲美替尼。目前几种新药正处于3期临床试验阶段,以期更多的药物被批准用于这种...     

Bayesian analysis of mixtures in structural equation models with non‐ignorable missing data

Structural equation models (SEMs) have become widely used to determine the interrelationships between latent and observed variables in social, psychological, and behavioural sciences. As heterogeneous data are very common in practical research in these fields, the analysis of mixture models has received a lot of attention in the literature. An important issue in the analysis of mixture SEMs is the presence of missing data, in particular of data missing with a non‐ignorable mechanism. However, only a limited amount of work has been done in analysing mixture SEMs with non‐ignorable missing data. The main objective of this paper is to develop a Bayesian approach for analysing mixture SEMs with an unknown number of components and non‐ignorable missing data. A simulation study shows that Bayesian estimates obtained by the proposed Markov chain Monte Carlo methods are accurate and the Bayes factor computed via a path sampling procedure is useful for identifying the correct number of components, selecting an appropriate missingness mechanism, and investigating various effects of latent variables in the mixture SEMs. A real data set on a study of job satisfaction is used to demonstrate the methodology.     

国外护理硕士教育与临床实践效果的研究现状

通过文献分析法,一方面探讨美国、英国、日本、泰国护理硕士研究生的招收条件、培养目标与课程设置、综合评定考核方法等,了解国外护理硕士培养机制;另一方面分析国外护理硕士课程对临床护理的影响,以及毕业后从事临床护理的实践效果和临床工作中面临的挑战,以期为我国护理硕士教育的发展提供借鉴.     

腹腔镜在女性盆底修复术中的应用

随着社会老龄化的加剧,盆底功能障碍性疾病的发病率日益上升.之前热门的盆底重建术随着时间的推移,并发症相继出现.美国食品药品管理局(FDA)连续两次发布了关于经阴道网片的警告,使专家们认识到了问题的严重性.经过30余年的发展,腹腔镜技术已经被广泛地应用于各类妇科手术中.腹腔镜在女性盆底修复术中的应用重新得到了关注.自1991年腹腔镜技术首次应用于女性盆底修复手术中以来,国内外不断有新的腹腔镜下盆底修复术式的报道.现就各种腹腔镜下盆底修复手术做一综述.     

海峡两岸大学生生命意义比较研究——以广州市与台中市为例

该研究以广州市与台中市大学生为被试,抽取500人为预测样本及800人为正式施测样本,通过探索性因素分析和验证性因素分析编制生命意义量表,并通过t检验和潜在剖面分析考察两岸大学生生命意义现况的差异.结果表明：（1）编制的生命意义量表由存在意义、追寻意义、存在盈实、苦难接纳、死亡接纳以及求意义的意志等6个维度组成,具有良好的信度和效度.（2）两岸大学生生命意义总体无显著差异;存在盈实、苦难接受与死亡接纳维度有显著或非常显著的差异.（3）潜在剖面分析结果显示,两岸大学生生命意义类型相似.Wald检验结果表明,对于“死亡接纳”维度,台湾与大陆学生在各潜在类别的均分上存在显著的差异.     

Intuitive Conceptions of Dead Persons' Mentality: A Cross-Cultural Replication and More

Jesse Bering (2002) investigated how American university students in an interview task conceived of dead persons' mentality immediately after death. He found that different categories of mental states or capacities were conceived differently: psychobiological and perceptual states ceased, whereas emotional, desire, and epistemic states continued. Our Study 1 was a replication of Bering's experiment in a different cultural setting, in which the subjects were Chinese undergraduate students. A similar pattern of results was found. In Study 2, instead of being asked about a dead person's various mental states immediately following the death, participants were asked to judge a dead person's mental states after the person had been dead for 2 days. The overall pattern of participants' responses was not affected by this manipulation, but they did show an increase in attributions of certain mental states to dead agnostics. In addition, a more refined breakdown of responses revealed that individuals tended to judge that, upon death, visual and auditory perception continued, whereas olfactory and gustatory sensation ceased.     

The development of social value orientation across different contexts

This study aimed to explore Chinese children's social value orientation across different ages and contexts. Revised decomposed games were used to measure the social value orientation of 9‐, 11‐, and 14‐year‐old children and college students as an adult group. About half of them were assigned to the hypothetical context of “equal payment group,” providing equal compensation for participation in the study, and the others to the “real payment group,” who got payment according to their own choices in the games. Results showed that 9‐ and 11‐year‐old children's choices differed between the two contexts: They made more prosocial choices in the hypothetical context, and more competitive choices in the “real payment” context. The 14‐year‐olds’ and adults’ choices were not significantly different in the two contexts. These results may imply that by 14 years of age, children have stable social value orientation, and their behavior reflects this value.     

How Speech Modifies Visual Attention

Auditory distractions can have serious consequences in critical situations such as driving. Mobile phones, radios, media players, and information devices that interpret and produce speech are increasingly common in vehicles, but the threats to visual attention are not yet fully understood. In three experiments, we found that most speech tasks had relatively small adverse effects on the detection of a briefly presented target among distractors across a 60° subarea of the visual field. Although there was a little impact on detectability, moderately difficult speech tasks slowed responding relative to silence. Our most demanding condition—generating and speaking a word beginning with the last letter of another word—had the greatest effects on accuracy and latency, with responding slowed by about 900 ms. An impairment of this magnitude presents a significant threat to safe driving and calls into question the belief that hands‐free voice‐controlled devices are the answer to the problem of driver distraction. Copyright © 2013 John Wiley & Sons, Ltd.     

Core Knowledge Employee Creativity and Firm Performance: The Moderating Role of Riskiness Orientation,Firm Size,and Realized Absorptive Capacity

In this study, we examine when creativity is positively or negatively related to firm performance. Building on the creation–implementation tension theorized in the literature and the attention capacity perspective, we argue that the relationship between creativity and firm performance is contingent on riskiness orientation, firm size, and realized absorptive capacity. Data were collected from 761 core knowledge employees, 148 CEOs, and 148 HR executives from 148 high‐technology firms. The results indicated that core knowledge employee creativity was negatively related to firm performance when riskiness orientation was high. The relationship was positive when realized absorptive capacity was high. Finally, the relationship was more positive in small firms than in large firms. We discuss the implications of our findings for creativity research and managerial practices.