缺血修饰白蛋白在急性冠脉综合征中的临床应用研究

缺血修饰白蛋白(IMA),是一种反映急性心肌缺血的新的生化标志物,具有灵敏度高、阴性预测值高、时间窗窄等优点,是第一个经美国食品药品管理局(FDA)批准销售的心肌缺血标志物.近年来诸多研究证明缺血修饰蛋白在急性冠脉综合征的早期诊断、危险分层、指导治疗以及评估预后等方面具有重要临床意义,是目前较为理想的检测心肌缺血的生化标志物.本文就IMA的形成机制、检测方法及临床应用研究等方面作一综述.     

Sinful flesh: Sexual objectification threatens women's moral self

The current investigation examined whether sexual objectification leads to perceived contamination in women victims, which, in turn, triggers sinful feelings. The results of three experiments provide converging support for these predictions. Female participants reported greater sinful feelings than their non-objectified counterparts, after receiving objectifying comments on their physical appearance from an alleged male partner (Experiment 1) or recalling a past experience of objectification (Experiments 2 and 3). Furthermore, perceived contamination mediated the effect of objectification on sinful feelings. We also found that perceived personal responsibility of being objectified moderated the above effects, such that the effects were only observed among participants who perceived themselves as highly responsible for objectification experience, but not among those who perceived low personal responsibility. These findings contribute to the literature by explaining why objectification elicits sinful feelings in female victims and who is more susceptible to this influence.     

Scientific Realism and the Meanings of Theoretical Terms

In contemporary philosophy of science, there are many interesting arguments for and against scientific realism with regard to the meaningfulness and truthfulness of theoretical statements. Some anti-realists hold that since many important concepts in scientific theories have no specific referents, the relevant theoretical statements are therefore either false or meaningless. In this essay, I join the debates concerning the plausibility of scientific realism by focusing on two intertwined issues： first, that of how we can we explicate the meaningfulness of theoretical statements, especially statements pertaining to unobservable objects, and second, that of the meaningfulness of theoretical statements for our acceptance of scientific realism.     

慢性应激性抑郁发生中大鼠眶额叶多巴胺D1受体对谷氨酸及其NMDA受体的调节

本文旨在探讨慢性应激性抑郁发生过程中眶额叶多巴胺D1受体对谷氨酸(glutamic acid, Glu)及其N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid, NMDA)受体的NR2B亚基的影响。实验通过建立慢性不可预见性温和应激(chronic unpredictable mild stress, CUMS)抑郁模型, 结合眶额叶微量注射多巴胺D1受体激动剂SKF38393和多巴胺D1受体拮抗剂SCH23390, 运用糖水偏爱测试、悬尾实验和敞箱实验等方法检测动物的行为表现, 采用高效液相色谱法(high-performance liquid chromatography, HPLC)和蛋白质免疫印迹法(Western blot, WB)来检测眶额叶内谷氨酸、多巴胺含量及NR2B和多巴胺D1受体的表达。结果显示, 与对照组相比, CUMS组大鼠表现出明显的抑郁样行为变化, 且眶额叶多巴胺含量降低, 其D1型受体表达降低, 谷氨酸含量升高, 其NMDA受体的NR2B亚基也明显上调; 注射SKF38393后可明显改善应激引起的抑郁样行为, 且眶额叶谷氨酸含量显著下降, NMDA受体的NR2B亚基表达也有所降低; 正常大鼠注射多巴胺D1受体拮抗剂SCH23390, 大鼠表现出和CUMS模型组相似的抑郁样行为, 且眶额叶谷氨酸含量升高, 其NMDA受体的NR2B亚基也明显上调。以上结果表明, 慢性不可预见性应激可能使眶额叶多巴胺释放减少, 从而使谷氨酸过量释放, NMDA受体过度激活, 导致抑郁发生。多巴胺抗抑郁作用是通过D1型受体抑制谷氨酸及其NMDA受体NR2B亚基表达来实现。     

不同情绪效价的DRM词表对错误记忆的影响

请49名在校大学生对自编的36个具有不同情绪效价的DRM词表进行评定,再以60名在校大学生为实验对象考察不同情绪效价的DRM词表对错误记忆的影响。结果发现,(1) 负性和中性DRM词表产生的错误记忆量显著高于正性DRM词表;(2) 被试在“记得/知道/猜测”判断上对负性和中性词表的关键诱饵倾向于“知道”,而对正性词表的关键诱饵更倾向于“记得”。结果表明,DRM词表本身所具有的情绪与人为诱发的情绪,对错误记忆的影响具有不同的性质和特点。     

How do children coordinate information about mental states with social norms?

We investigated how 3-7-year-olds weigh and coordinate information about specific mental states with social norms in the domain of contextually conventional rules. With increasing age, participants increasingly took into account an actor's mental state to predict that actor's behavior. In a criticism judgment task, 7-year-olds could assign criticism conditional on mental state, with response patterns similar to those of adults; 5-year-olds assigned criticism regardless of the actor's mental state. Three-year-olds tended not to assign criticism at all, irrespective of the actor's mental state. Results indicated that the ability to weigh and coordinate information about mental states with understanding of norms depends on age and on the particular type of judgment being made. To some extent, our results may also reflect the influence of culture and parenting.     

口腔种植诊疗实践中的思考

口腔种植现已经出现在人们的视线里,它具有一定的特殊性和优越性,能够解决常规修复手段不能解决的问题,然而在临床应用中,需要考虑和处理的问题往往很复杂.因此有必要在临床实践中运用辩证思维及循证医学的思想,在诊断中全面考虑、周密计划;在治疗中处理问题、解决难点;在随访中发现问题,促进发展.     

大型综合性医院手术室统筹及加快周转的措施

科学的统筹规划、紧凑有序的接台管理,能够更好地服务患者,提高医院工作效率.探索大型综合性医院手术室合理有效地安排手术、加快手术周转的措施.讨论如何有效利用手术室的物资和人力资源,进行全盘科学的筹划,抓住关键环节,合理安排工序.进而成功破除制约手术科室的瓶颈,大大提高了手术科室的效率.     

愤恨、惩罚与正义——亚当·斯密惩罚理论的一种解读

愤恨是人性中必不可少的组成部分.在斯密看来,这种通常似乎令人憎恶的激情,其基于合宜性的表达却成为捍卫社会正义与平等的心理机制.作为立即和直接促使人们去惩罚的情感,尽管需要怀疑其合理性,但合宜的愤恨不仅成为社会惩罚的基础,也是正义的保证.它所确立的正义感,肯定惩罚的正当性而确认正义的法则体系,其所衍生的功过赏罚的报偿结构,也将促成人性的完善和社会公正的实现.     

Twelve‐ to 14‐month‐old infants can predict single‐event probability with large set sizes

Previous research has revealed that infants can reason correctly about single‐event probabilities with small but not large set sizes ( Bonatti, 2008 ; Teglas et al., 2007 ). The current study asks whether infants can make predictions regarding single‐event probability with large set sizes using a novel procedure. Infants completed two trials: A preference trial to determine whether they preferred pink or black lollipops and a test trial where infants saw two jars, one containing mostly pink lollipops and another containing mostly black lollipops. The experimenter removed one occluded lollipop from each jar and placed them in two separate opaque cups. Seventy‐eight percent of infants searched in the cup that contained a lollipop from the jar with a higher proportion of their preferred color object, significantly better than chance. Thus infants can reason about single‐event probabilities with large set sizes in a choice paradigm, and contrary to most findings in the infant literature, the prediction task used here appears a more sensitive measure than the standard looking‐time task.