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Raymond Oppong Billingsley Kaambwa Jacqui Nuttall Kerenza Hood Richard D. Smith Joanna Coast 《Applied research in quality of life》2011,6(4):411-423
Although EQ-5D has been used in the context of acute cough/lower respiratory tract infections (acute cough/LRTI), it has not
been formally validated in this disease area. The primary aim of this study is to assess the construct validity of EQ-5D as
a measure for economic evaluation in the context of acute cough/lower respiratory tract infections. Data were collected alongside
an observational study of the management of patients with acute cough/LRTI in thirteen European countries. However, the analysis
was limited to 349 patients from the UK. Hypotheses were specified a priori and tested in order to establish the construct
validity of EQ-5D. Statistical methods used to test the a priori hypotheses included Wilcoxon signed rank sum test, Kruskal-Wallis
test, Chi-square test and regression analysis. Most of the relationships that were tested were in line with the a priori hypotheses.
The main results indicate that there was a negative relationship between symptom severity scores and EQ-5D, smoking was associated
with worse EQ-5D scores and EQ-5D was able to discriminate between patients with headache, interference with normal activities
and disturbed sleep. This study also showed that the EQ-5D is moderately responsive in patients with acute cough/LRTI, and
is a suitable measure for use in economic evaluation studies of acute cough/LRTI 相似文献