Authorial intentions and metaphor comprehension

Three experiments investigated the role of authorial intentions in metaphor comprehension. In these studies, subjects read metaphoric (e.g., A family album is like a museum), literal (e.g., An art gallery is like a museum), and anomalous (e.g., A tortoise shell is like an art gallery) comparisons and rated their degreeof meaningfulness (Experiment 1), made speeded decisions as to whether each phrase was meaningful or not (Experiment 2), or wrote out interpretations of each comparison statement (Experiment 3). The subjects were tolt that the comparisons were written either by famous 20th century poets or by a computer program that randomly generated the statements from a list of words. Our general hypothesis was that knowing that intentional agents (the poets) authored the different comparisons should facilitate subjects' comprehension of the metaphors. Experiment 1 showed that subjects rated both metaphoric and literal comparisons as being more meaningful in the poet condition than when these statements were supposedly written by computer. Experiment 2 demonstrated that subjects were faster in making their meaningfulness judgments for metaphors in the poet condition than in the computer context, but that subjects were also slower in rejecting anomalous comparisons when these were supposedly written by the poets. Experiment 3 indicated that subjects produced more meanings or interpretations for comparisons presumably written by poets than by computer. These results highlight the improtance of implied, authorial intentions in understanding metaphorical statements. We discuss the implications of this work for psycholinguistic theories of figurative language comprehension, as well as for theories of literary interpretation.     

医院公共空间环境对病人心理的影响分析

医院公共空间设置应契合使用者对医院总体空间的使用需求,分析其心理、生理和行为特点,满足病人生理、心理和行为的需求。充分考虑病人对空间环境的响应度,对不同空间类型应提供多样支持,关注空间环境对病人的生理、心理和行为的影响,顺应医疗流程,防止和控制交叉感染。     

Effects of Parent’s Gender, Child’s Gender, and Parental Involvement on the Academic Achievement of Adolescents in Single Parent Families

We used a national database (Educational Longitudinal Study) to investigate the effects of parent’s gender, child’s gender, and parental involvement in school on the academic achievement of adolescents in single-parent families. A three way 2 × 2 × 2 (parent’s gender × child’s gender × parental involvement) MANCOVA was conducted with four student academic achievement indicators as dependent variables and SES as a covariate. The results indicated that parent gender and child gender interact with parent involvement to affect adolescents’ academic achievement differentially. Specifically, daughters who lived with highly involved single-fathers performed better academically than the other groups did. These findings suggest that researchers who study single-parents’ involvement in their adolescents’ academic achievement need to pay more attention to gender-specific effects.     

Cortisol Rhythm in Preschoolers: Relations with Maternal Depression and Child Temperament

Evidence supports associations between deviations from the normative daily cortisol rhythm and depression. We examined associations between multiple indices of daily cortisol in 146 preschool-aged children and two well-established risk factors for depression: maternal depression and early child temperament (negative emotionality/NE and positive emotionality/PE). Offspring of mothers with current depression demonstrated lower waking cortisol and lower total post-awakening cortisol. Child PE was negatively associated with waking cortisol. The combination of maternal depression history and high child NE was associated with higher levels of evening cortisol. Findings suggest that an interplay between familial risk for depression and child temperamental vulnerability may be related to neuroendocrine functioning in young children and highlight important methodological considerations in the assessment of children’s basal cortisol activity. It will be critical for future research to map the developmental progression from early disruptions in children’s cortisol rhythm to the emergence of psychopathology.     

瓜蒌皮与前列地尔预处理对心肌缺血再灌注的影响

探讨瓜蒌皮和前列地尔预处理对心肌缺血再灌注的作用机制.通过建立SD大鼠心肌缺血再灌注的模型,采用Tunel法检测组织样本细胞凋亡和免疫组化法检测bax,bcl-2,caspase-3的蛋白表达情况进行研究.结果显示,瓜蒌皮和前列地尔半剂量联合组的凋亡细胞数、Bax和caspase-3的蛋白表达量较其他各实验组均明显降低,Bcl-2的表达量升高,且有统计学意义(P＜0.05);瓜蒌皮单用药组也表现为凋亡细胞数、Bax和caspase-3的表达量降低,Bcl-2的表达量升高,但程度不如两组联合用药组.实验可以证明细胞凋亡发生在心肌缺血/再灌注损伤中,瓜蒌皮可对心肌缺血/再灌注起保护作用,并且与前列地尔联合后更有利于对心肌细胞的保护作用.     

Return of Genetic Results in the Familial Dilated Cardiomyopathy Research Project

The goal of the Familial Dilated Cardiomyopathy (FDC) Research Project, initiated in 1993, has been to identify and characterize FDC genetic cause. All participating individuals have been consented for the return of genetic results, an important but challenging undertaking. Since the inception of the Project we have enrolled 606 probands, and 269 of these had 1670 family members also enrolled. Each subject was evaluated for idiopathic dilated cardiomyopathy (IDC) and pedigrees were categorized as familial or sporadic. The coding regions of 14 genes were resequenced in 311 to 324 probands in five studies. Ninety-two probands were found to carry nonsynonymous rare variants absent in controls, and with Clinical Laboratory Improvement Amendment of 1988 (CLIA) compliant protocols, relevant genetic results were returned to these probands and their consented relatives by study genetic counselors and physicians in 353 letters. In 10 of the 51 families that received results >1 year ago, at least 23 individuals underwent CLIA confirmation testing for their family’s rare variant. Return of genetic results has been successfully undertaken in the FDC Research Project. This report describes the methods utilized in the process of returning research results. We use this information as a springboard for providing guidance to other genetic research groups and proposing future directions in this arena.     

The hierarchical structure of the Dimensional Assessment of Personality Pathology (DAPP-BQ)

Hierarchical personality models have the potential to identify common and specific components of DSM-IV personality disorders (PDs), and may offer a solution for the re-tooling of personality pathology in future versions of the DSM. In this paper, we examined the hierarchical structure of the Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ; Livesley & Jackson, 2009) and the capacity of various trait components at different levels to predict DSM-IV PD symptoms. Participants were 275 psychiatric outpatients and 365 undergraduate students. Goldberg's (2006) bass-ackwards method was used to investigate the hierarchical structure of the DAPP-BQ. The predictive capacity of hierarchy components was assessed. We found that Level 5 of the hierarchy enhanced the capacity of the DAPP-BQ for predicting DSM PD symptoms beyond a four-factor structure, particularly for borderline PD.