Introduction

The papers in this special issue make important contributions to a longstanding debate about how we should conceive of and explain mental phenomena. In other words, they make a case about the best philosophical paradigm for cognitive science. The two main competing approaches, hotly debated for several decades, are representationalism and enactivism. However, recent developments in disciplines such as machine learning and computational neuroscience have fostered a proliferation of intermediate approaches, leading to the emergence of completely new positions, in particular the Predictive Processing approach. Here, we will consider the different approaches discussed in this volume.     

Evaluation of drug toxicity in clinical trials

An increasing number of drugs removed from the market because of unacceptable toxicity raises concerns regarding preapproval testing of drug safety. In the present paper it is postulated that the non-inferiority type of trial should be abandoned in favor of the superiority trial with active controls and less stringent (p<0.1, both for efficacy and toxicity) statistics. This approach will increase sensitivity of detection of drug-induced adverse effects at the expense of increasing false positive results regarding the difference in efficacy between the tested and reference drug. Such a move will increase the protection of future patients. In addition, the proposed design is far more acceptable from the clinical (e.g. no need to specify the statistically expected “unimportant” number of deaths) and ethical points of view, as well as being favored by the strong incentive of involved parties. In the second part of this paper arguments are presented in favor of the hypothesis that placebo (still used in some superiority trials) does not induce adverse effects. The assertion that placebo may induce adverse effects is probably biased by the nature of the clinical experiment. Such a conclusion is supported by studies indicating that placebo-induced adverse effects are disease — and treatment — specific. The modification of clinical trials according to the proposed changes may increase the trials’ sensitivity at detecting adverse effects of drugs. A lecture on the subject of this paper was presented at the 6th International Bioethics Conference on the subject of ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005.     

The relationship between latency of auditory evoked potentials,simple reaction time,and stimulus intensity

Summary The effects of loudness on the latency of evoked potentials and on simple reaction time were compared. It was found that both reaction time and the evoked-potential latency increases with decreasing stimulus intensity. However, different slopes of the curves were found. This is explained in terms of the arousal effect of loud auditory stimuli.     

Towards a topological philosophy

This article examines the use of mathematical concepts in philosophy, focusing on topology, which may be viewed as a modern supplement to geometry. We show that Plato and Parmenides were already employing geometric ideas in their research, and discuss three examples of the application of topology to philosophical problems: the first concerns the analysis of the Cartesian distinction between res extensa and res cogitans, the second the ontology of possible worlds of Wittgenstein's Tractatus, and the third Leibniz's monadology. We also consider the role of topology in mathematical explanations of the sort found in science, arguing that it can perform a role in philosophy that is of comparable importance.     

Can appraisals of common political life events impact subjective well‐being?

This study examined the psychological impact of global subjective appraisals of influence exerted on people's lives by common political events. A list of 24 political events was administered to a random sample of 400 adults in Poland. Political self‐efficacy, interest in politics, perceived political social support, and political collective efficacy were also assessed as potential moderators of the link between political stress appraisals and subjective well‐being (satisfaction with life, sense on anomie, positive affect). Perceptions of the negative influence of political stressors on one's life and the life of the country were associated with concomitant variations in subjective well‐being. Among psychosocial resources, political self‐efficacy consistently moderated the influence of appraisals of political stressors on satisfaction with life and positive affect.     

Throwing spatial light: on topological explanations in Gestalt psychology

Phenomenology and the Cognitive Sciences - It is a well-known fact that mathematics plays a crucial role in physics; in fact, it is virtually impossible to imagine contemporary physics without it....     

Religion and Spirituality in Oncology: An Exploratory Study of the Communication Experiences of Clinicians in Poland

Journal of Religion and Health - Communication with patients regarding&nbsp;oncology-related aspects is a challenging experience and requires a high level of skill from the interlocutors. The...     

AC loss density component in electrical steel sheets

This article proposes a new approach to the loss separation issue. The conventional loss separation into three components is abandoned. The dependence of the dynamic component of loss density versus frequency is assumed to be a power law. The model is verified for selected samples of nonoriented and grain-oriented steel.     

Tischner as a metapolitician

Studies in East European Thought - Józef Tischner, a Polish philosopher and a seasoned commentator on the political transformations associated with the decline of communism and the building of...