An 8q21 deletion in a patient with comorbid psychosis and mental retardation

Systematic investigations indicate that some of the recognized psychiatric disorders can be identified among those with mental retardation due to chromosomal abnormalities. We report a psychotic patient with mild mental retardation (intelligence quotient: 68) and minor anomalies that had a chromosomal aberration not previously described in a psychotic patient. Our patient highlights the importance of the cytogenetic study in psychiatric patients with comorbid mental retardation or minor anomalies. In addition, her psychosis symptoms may be helpful to propose a new candidate gene for psychosis.     

Basic information processing of neurotics and stables: an experimental ERP approach to personality and distractibility

The aim of the study was to investigate the effects of level of neuroticism on electrophysiological event-related potentials (ERPs) to different kinds of stimuli. The neuroticism items from the NEO-PI-R were administered to 168 female, right-handed undergraduates between 19 and 29 years of age. 20 highly neurotic and 22 highly stable persons underwent an ERP task that was designed to be a combination of an auditory P3a and a visual P3b oddball task. No significant differences in the P3a and P3b were detected. It is concluded that highly neurotic and highly stable persons do not differ in fast neurocognitive processing of neutral stimuli, and that cognitive differences between the groups may be located at another level in the sequence of information processing stages.     

Do Conditional Hypotheses Target Rare Events?

When testing hypotheses, rare or unexpected observations are normatively more informative than common observations, and recent studies have shown that participants' behavior reflects this principle. Research has also shown that, when asked to test conditional hypotheses (“If X, then Y”) that are abstract or unfamiliar, participants overwhelmingly consider a supporting observation mentioned in the hypothesis (X&Y) to be more informative than a supporting observation not mentioned (XY). These two empirical findings would mesh well if conditional hypotheses tend to be phrased in terms of rare, rather than common, events. Six experiments are reported indicating that people do have a tendency—often a very strong one—to phrase conditional hypotheses in terms of rare events. Thus, observations mentioned in conditional hypotheses might generally be considered highly informative because they usually are highly informative.     

Development of an Interactive Decision Aid for Female BRCA1/BRCA2 Carriers

Shared decision making between patients and providers is becoming increasingly common, particularly when there is no clear preferred course of action. As a result, decision aids are being adopted with growing frequency and have been applied to many medical decision-making issues. One such issue where there is uncertainty is breast cancer risk management among BRCA1/BRCA2 carriers. We present the development of a CD-ROM decision aid to facilitate risk management decision making in this population. Our decision aid was developed with the intention of providing it through a randomized clinical trial. The CD-ROM is a multimedia, interactive intervention which provides information about breast cancer, risks associated with BRCA1 and BRCA2 mutations, risk management options for hereditary breast cancer, and a breast cancer risk management decision aid. The goal of this CD-ROM, offered as an adjunctive intervention, is to reduce decisional conflict and psychological distress and improve comprehension of risk information, decisional satisfaction, medical adherence, and quality of life for this population of women at increased risk for breast cancer.     

Accompagnement médical et communautaire dans un essai de prévention biomédicale : vers une nouvelle forme d’éducation ?

The recent implementation of innovative biomedical preventive approaches to combat the continued high prevalence of HIV among certain populations, has refocused attention on the question of support in the management of treatment adherence. What distinguishes these approaches from classic research on similar themes is that the populations concerned are not HIV positive. The objective of this study was to assess participant and physician satisfaction with medical and community support provided in the ANRS-IPERGAY trial. As part of this trial, individual interviews were conducted with physicians and with HIV-negative participants involved in the trial. Collective interviews and focus groups were also conducted with the participants. A content thematic analysis was performed on the full two corpuses’ data, with the aim of investigating discourse themes regarding the support offered as part of the trial. The discourse analysis of the HIV-negative participants and physicians underlined their satisfaction with many aspects of the medical and community support provided during the trial. The results were interpreted with respect to new forms of patient education necessary for the implementation of the medicalized prevention.     

Assessing the social validity of telehealth-based applied behavior analysis services for autism spectrum disorder

During the COVID-19 pandemic, applied behavior analysis services for many autistic individuals were transitioned to telehealth. The current study assessed caregiver-reported quality of life (QoL) and social validity for families of autistic children receiving only telehealth services (n = 96) or a combination of telehealth and in-person services (n = 173). Barriers to the telehealth experience were analyzed via an ANOVA, and the impact of funding source was analyzed using an independent samples t-test. Caregivers reported benefit across QoL and social validity items, with scores ranging from 3.31 to 4.44 (1 = least benefit, 5 = most benefit). While many caregivers reported no barriers regarding technology (44.61%), childcare (69.52%), and employment (64.68%), the presence of those barriers significantly impacted QoL and social validity scores. Funding source was not found to have a significant impact. Overall, caregivers found value in their child's telehealth services. Clinicians have an obligation to mitigate barriers to ensure the success of the intervention.     

Do 6‐month‐olds understand that speech can communicate?

Adults and 12‐month‐old infants recognize that even unfamiliar speech can communicate information between third parties, suggesting that they can separate the communicative function of speech from its lexical content. But do infants recognize that speech can communicate due to their experience understanding and producing language, or do they appreciate that speech is communicative earlier, with little such experience? We examined whether 6‐month‐olds recognize that speech can communicate information about an object. Infants watched a Communicator selectively grasp one of two objects (target). During test, the Communicator could no longer reach the objects; she turned to a Recipient and produced speech (a nonsense word) or non‐speech (coughing). Infants looked longer when the Recipient selected the non‐target than the target object when the Communicator spoke but not when she coughed – unless the Recipient had previously witnessed the Communicator's selective grasping of the target object. Our results suggest that at 6 months, with a receptive vocabulary of no more than a handful of commonly used words, infants possess some abstract understanding of the communicative function of speech. This understanding may provide an early mechanism for language and knowledge acquisition.     

Preferences Regarding Targeted Education and Risk Assessment in People with a Family History of Major Depressive Disorder

Genetic testing for susceptibility to major depressive disorder (MDD) is not available for clinical use at present. Given this, family history remains the best predictor for development of MDD, and family-history-based risk assessment and information about familial aspects of MDD may be useful to clients at increased risk for MDD attending for genetic counseling. This study uses a mixed-methods design to assess the information needs and preferences of people at increased familial risk for MDD. Telephone interviews were conducted with 23 individuals, who had at least one first-degree relative with MDD and were recruited through advertisements placed on depression education websites. The most preferred way to access depression information was via the internet (87 % of participants), although this preference may have been due to the internet-based recruitment method. The second most preferred dissemination strategy (56 %) was face-to-face delivery through a health professional, including genetic counselors. Individuals reported a need for information about etiology and development of MDD, reproductive decision-making, early detection of symptoms and risk-reducing strategies. Nearly all participants expressed an interest in risk assessment. The present study found evidence of a high level of interest for information targeted to people at increased familial risk for MDD. Genetic counselors are likely to be called upon increasingly to provide supportive counseling to assist clients at increased familial risk in interpreting and contextualizing such information once it becomes available.     

Formation for the Whole Church: A New/Old Vision of Theological Education in the 21st Century

This article offers a proposal for a vision of theological education beyond the boundaries of training and teaching for traditional professional ministry roles. Particular attention will be given to the idea of education as formation and the shared role academic institutions have with congregations. Implications for reshaping definitions of student and faculty will be explored.