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951.
Exposure to stress is associated with susceptibility to disease and one stress mediator, norepinephrine, has been reported to enhance the adherence of enterohemorrhagic Escherichia coli O157:H7 (EHEC) to the colonic mucosa. We tested the hypothesis that adrenocorticotropic hormone (ACTH) and other stress-related hormones may act in a similar fashion. Explants of distal colonic mucosa from young pigs were mounted in Ussing chambers and their luminal aspect was exposed to EHEC strain 700728 for 30-90 min. When added to the contraluminal, but not luminal bathing medium, ACTH increased EHEC adherence within 90 min in a concentration-dependent manner (EC50 = 1.2 nM), but did not alter tissue electrical conductance. ACTH had no effect on the adherence of a pig-adapted non-O157 E. coli strain. The effect of 0.1 microM ACTH on luminal EHEC adherence was prevented in tissues pretreated contraluminally with the type 2 melanocortin receptor antagonist ACTH7-38, the neuronal conduction blocker saxitoxin, or the muscarinic cholinergic antagonist atropine. Moreover, ACTH7-38 decreased EHEC adherence in the absence of ACTH. These results suggest that ACTH acts via melanocortin receptors located on enteric nerves to enhance mucosal adherence of EHEC. 相似文献
952.
Shrader-Frechette K 《Science and engineering ethics》2005,11(4):518-520
On August 22, 2005 the U.S. Environmental Protection Agency issued proposed new regulations for radiation releases from the
planned permanent U.S. nuclear-waste repository in Yucca Mountain, Nevada. The goal of the new standards is to provide public-health
protection for the next million years — even though everyone admits that the radioactive wastes will leak. Regulations now
guarantee individual and equal protection against all radiation exposures above the legal limit. Instead E.P.A. recommended
different radiation exposure-limits for different time periods. It also recommended using only the arithmetic mean of the
dose distribution, to assess regulatory compliance during one time period, but using only the median dose to assess compliance
during another period. This piece argues that these two changes — in exposure-limits and in methods of assessing regulatory
compliance — have at least four disturbing consequences. The changes would threaten equal protection, ignore the needs of
the most vulnerable, allow many fatal exposures, and sanction scientifically flawed dose calculations. 相似文献
953.
Recent research has shown that pride, like the "basic" emotions of anger, disgust, fear, happiness, sadness, and surprise, has a distinct, nonverbal expression that can be recognized by adults (J. L. Tracy & R. W. Robins, 2004b). In 2 experiments, the authors examined whether young children can identify the pride expression and distinguish it from expressions of happiness and surprise. Results suggest that (a) children can recognize pride at above-chance levels by age 4 years; (b) children recognize pride as well as they recognize happiness; (c) pride recognition, like happiness and surprise recognition, improves from age 3 to 7 years; and (d) children's ability to recognize pride cannot be accounted for by the use of a process of elimination (i.e., an exclusion rule) to identify an unknown entity. These findings have implications for the development of emotion recognition and children's ability to perceive and communicate pride. 相似文献
954.
Zvolensky MJ Feldner MT Leen-Feldner EW Gibson LE Abrams K Gregor K 《Behaviour research and therapy》2005,43(12):643-1700
Although previous work has found associations between panic and smoking, little research has investigated potential mechanisms by which smoking may contribute to panic problems. The present investigation evaluated the incremental validity of acute nicotine withdrawal symptoms (elicited by an average of 2 h of nicotine deprivation) relative to negative affectivity, anxiety sensitivity, and nicotine dependence in predicting anxiety responding to 3-min voluntary hyperventilation. The sample consisted of 90 regular smokers (46 females), as defined by smoking 10 cigarettes per day for at least 1 year, recruited through the general community. Consistent with prediction, greater levels of pre-challenge nicotine withdrawal symptoms uniquely predicted post-challenge intensity of panic symptoms and anxiety relative to other established factors. Findings are discussed in the context of how regular smoking may promote panic symptomotology. 相似文献
955.
This article is an overview of the relationship education field in Norway. We explain the roles of the national authorities and private organizations in education, and analyze achievements and challenges in the field. Involvement and economic support from the national authorities have made relationship education available to large groups of the population, though the characteristics of those who choose to attend are largely unknown. To ensure recruitment of those most in need of education, new strategies based on systematic information on barriers among different groups of the population must be developed. A variety of relationship education programs are offered by public and private organizations, with the U.S.-developed Prevention and Relationship Enhancement Program (PREP) being the most widespread. We present preliminary data of an effectiveness evaluation of PREP workshops in Norway. In general, participants evaluate the workshops positively. It is important to tailor relationship education to fit the various customs, beliefs, and challenges of couples attending programs. 相似文献
956.
Snyder CR Berg C Woodward JT Gum A Rand KL Wrobleski KK Brown J Hackman A 《Journal of personality》2005,73(2):287-312
Hope theory (see Snyder, 1994) is presented as a useful framework for understanding reactions to pain. In Study 1, persons scoring higher on the trait Hope Scale (Snyder, Harris et al., 1991) kept their hands in the freezing water (of a cold pressor task) for significantly longer. In Study 2, the higher-hope males, and not females, as measured by both trait and state hope (Snyder, Sympson et al., 1996), recognized the onset of the pain threshold significantly later. Moreover, in Study 2, results showed that individual differences measures of optimism, self-efficacy, depression, and positive and negative affects did not relate to the pain onset and tolerance variables. The implications of hope as related to the pain process and related research are discussed. 相似文献
957.
Goal activation, expectations, and the placebo effect 总被引:1,自引:0,他引:1
Geers AL Weiland PE Kosbab K Landry SJ Helfer SG 《Journal of personality and social psychology》2005,89(2):143-159
Motivational factors receive little attention in current theories of the placebo effect. Reasons for this position are reviewed, and an argument is made for reconsidering the influence of motivation on the placebo effect. The authors hypothesize that nonconscious goals alter reactions to a placebo expectation. Specifically, the authors predict that the placebo effect is most likely to occur when individuals have a goal that can be fulfilled by confirmation of the placebo expectation. The authors tested this notion in 5 experiments. The results demonstrate the role of motivation in the placebo effect across a variety of symptom domains and via 4 different goal activation techniques. Moreover, this moderating effect occurred for both positive and negative placebo expectations, across different placebo effect measures, and in brief laboratory experiments as well as in lengthier studies. It is argued that theories regarding the placebo effect should incorporate motivational factors. 相似文献
958.
Adult shyness: the interaction of temperamental sensitivity and an adverse childhood environment 总被引:2,自引:0,他引:2
This article examines the relation between adult shyness and sensory-processing sensitivity and posits a new model in which the interaction of sensitivity and adverse childhood environment leads to negative affectivity (with the highly sensitive being more impacted), which in turn leads to shyness. Consistent with this model, two questionnaire studies (Ns = 96 and 213) supported three hypotheses: (a) sensory-processing sensitivity interacts with recalled quality of childhood parental environment to predict shyness, (b) sensory-processing sensitivity interacts in the same way with childhood environment to predict negative affectivity, and (c) the interaction effect on negative affectivity mediates the effect on shyness. Hypothesis 2 was tested and supported in an additional questionnaire study (N = 393) and also in an experiment (N = 160) that manipulated negative contemporaneous experience as an analog for adverse childhood environment. 相似文献
959.
Erving Goffman's distinctive contribution to an understanding of others was grounded in his information control and ritual models of the interaction process. This contribution centered on the forms of the interaction order rather than self-other relations as traditionally conceived in phenomenology. Goffman came to phenomenology as a sympathetic but critical outsider who sought resources for the sociological mining of the interaction order. His engagement with phenomenological thinkers (principally Gustav Ichheiser, Jean-Paul Sartre and Alfred Schutz) has to be understood in these terms. The article traces basic differences in analytical focus through a range of phenomenological critiques of Goffman and a comparison of salient aspects of Schutz's and Goffman's writings. While the contrasts have perhaps been overplayed, I conclude that Goffman's thinking about others probably owed more to his pragmatist roots than to his later encounters with phenomenology.Earlier versions of this paper were presented at the Annual Meeting of the Society for Phenomenology and the Human Sciences in 1992 and 2003. I am grateful to discussions with participants at both meetings, which helped to clarify my ideas on a number of the paper's themes. 相似文献
960.
The authors examined whether the quality and content of everyday parent-child conversations about negative emotions are the same or different from everyday talk about positive emotions. Extensive longitudinal speech samples of 6 children and their parents were analyzed for several critical features when the children were between 2 and 5 years of age. Results showed that children and parents talked about past emotions, the causes of emotions, and connections between emotions and other mental states at higher rates during conversations about negative emotions than during conversations about positive emotions. Discourse about negative emotions also included a larger emotion vocabulary, more open-ended questions, and more talk about other people. These differences appeared before the children's 3rd birthdays and remained consistent through the preschool years. The findings strengthen and clarify current understanding of young children's articulation and knowledge about people's minds, lives, and emotions. 相似文献