Age-specific differences of dual n-back training

Age-related decline in executive functions can be decisive in performing everyday tasks autonomously. Working memory (WM) is closely related to executive functions, and training of WM has yielded evidence toward cognitive plasticity in older adults. The training effects often transfer to untrained tasks and functions. These effects have mostly been shown in processes such as WM and attention, whereas studies investigating transfer to executive functions have been scarce. We trained older adults aged 57–73 years in a WM training task that was reported to be effective in producing transfer in young adults. The training intervention consisted of a dual n-back task including independently processed auditory and visual n-back tasks. We investigated transfer to tasks engaging executive functions, and compared the effects in older adults to those reported in young adults. We found that both training groups improved in the training task. Although the training effect in older adults was smaller than the training effect in young adults, the older adults still showed a notable improvement so that after training they performed on the same level as young adults without training. The older adults also showed transfer to an untrained WM updating task, a result that was in accordance with the findings in young adults; other transfer effects in older adults were lacking. We conclude that although transfer effects were scarce, the present study provides encouraging evidence toward the possibilities to compensate for age-related decline in executive functions by a WM training intervention.     

Challenge and Conformity on “Contested Terrain”: Images of Women in Four Women’s Sport/Fitness Magazines

Women’s sport magazines were launched during the mid-to-late 1990s as a response to the growing women’s sport movement in the United States. These magazines, including Real Sports, Sports Illustrated for Women, and Women’s Sports & Fitness, were marketed as more active and sport-focused than established titles such as Shape, a popular magazine launched during the early 1980s for fitness-oriented women. Shape has been criticized by scholars for reinforcing male hegemony in US culture through its emphasis on sexual difference. In the present research, we analyzed photo images presented in Sports Illustrated for Women, Women’s Sports & Fitness, and Real Sports to assess the reinforcement or rejection of sexual difference in these magazines as gauged against the presentation of sexual difference in Shape. The results show that the newer magazines do, to varying degrees, contest male hegemony more than Shape does. The impact of these magazines is discussed, and we speculate on the reasons that, although Shape continues to thrive, these magazines have ceased publication.     

Stronger effects of self-generated than cue-induced expectations when verifying predictions in data graphs

Expectations can come in different forms when analyzing and presenting data. Prior studies have documented stronger effects (behavioral and electrophysiological) of self-generated predictions as compared to cues. While participants presumably cannot help but use their own predictions, they might sometimes ignore cues (of low validity). In two experiments we compared the impact of cues (verbal and visual) and self-generated predictions on the performance of participants checking their current prediction against a presented data graph (linear upward or downward trend). Different from prior studies, the setup allowed for within-experiment comparison of different cue formats and ensured that cues could not be ignored. Nevertheless we found that self-generated predictions had a stronger impact than cues. Verbal cues had a stronger effect than visual cues without verbalization. Responses to graphs with a linear upward trend were faster and were influenced more strongly by predictions, than the response to graphs with a downward trend.     

Protective behavioral strategies and the relationship between depressive symptoms and alcohol-related negative consequences among college students

Approximately 40% of college students reported engaging in heavy episodic or "binge" drinking in the 2 weeks prior to being surveyed. Research indicates that college students suffering from depression are more likely to report experiencing negative consequences related to their drinking than other students are. The reasons for this relationship have not been well-studied. Hence, the purpose of this study was to determine whether use of protective behavioral strategies (PBS), defined as cognitive-behavioral strategies an individual can use when drinking alcohol that limit both consumption and alcohol-related problems, mediated the relationship between depressive symptoms and alcohol-related negative consequences among college students. Data were obtained from 686 participants from a large, public university who were referred to an alcohol intervention as a result of violating on-campus alcohol policies. Results from structural equation modeling analyses indicated that use of PBS partially mediated the relationship between depressive symptoms and alcohol-related negative consequences. Implications for clinicians treating college students who report experiencing depressive symptoms or consuming alcohol are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved).     

ESSENTIAL STUFF

Here is a common view. There exist things, and there exists stuff, where roughly, ‘thing’ is a count noun, and ‘stuff’ is a mass noun. Syntactically, ‘thing’ functions as a singular referring term that takes ‘a’ and ‘every’ and is subject to pluralisation, while ‘stuff’ functions as a plural referring term that takes ‘some’ and is not subject to pluralisation. Hence there exists a thing, and some stuff. Usual versions of the common view endorse two principles about portions of stuff. The first principle is that (temporal) mereological essentialism is true of portions (parcels, masses, quantities) of stuff, where mereological essentialism is the thesis that for any persisting object or portion of stuff, that object or stuff has the same parts at every time at which it exists. 1 The second principle is that portions of stuff obey a principle of stuff composition: for any two portions of stuff P₁ and P₂, there exists a portion of stuff that is the fusion of P₁ and P₂. 1 I argue that these two principles are inconsistent. In particular, since I am sympathetic to PSC, I argue that mereological essentialism is false of portions of stuff.     

Field operational test of a seatbelt reminder system: Effects on driver behaviour and acceptance

The long-term effects on driver behaviour and acceptance of a seatbelt reminder system were examined in an on-road study. The system was capable of detecting seatbelt use in all seating positions and produced a two-stage visual and auditory warning if occupants were unrestrained. The effects of this system were evaluated alone and in combination with two other intelligent transport systems: intelligent speed adaptation and a following distance warning system. Twenty-three fleet car drivers drove an instrumented vehicle (SafeCar) for at least 16,500 km as part of their everyday driving. The results revealed that driver and passenger interaction with the seatbelt reminder system led to large and significant decreases in the percentage of trips where occupants were unbelted, in the percentage of total driving time spent unbelted, and in the time taken to fasten a seatbelt in response to system warnings. The seatbelt reminder system was rated by drivers as being useful, effective and socially acceptable, and led to a decrease in drivers’ subjective workload. These results were found even though the baseline pre-exposure seatbelt wearing compliance rates among participants were high.     

The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase

Recent studies have shown that nitric oxide (NO) signaling plays a crucial role in memory consolidation of Pavlovian fear conditioning and in synaptic plasticity in the lateral amygdala (LA). In the present experiments, we examined the role of the cGMP-dependent protein kinase (PKG), a downstream effector of NO, in fear memory consolidation and long-term potentiation (LTP) at thalamic and cortical input pathways to the LA. In behavioral experiments, rats given intra-LA infusions of either the PKG inhibitor Rp-8-Br-PET-cGMPS or the PKG activator 8-Br-cGMP exhibited dose-dependent impairments or enhancements of fear memory consolidation, respectively. In slice electrophysiology experiments, bath application of Rp-8-Br-PET-cGMPS or the guanylyl cyclase inhibitor LY83583 impaired LTP at thalamic, but not cortical inputs to the LA, while bath application of 8-Br-cGMP or the guanylyl cyclase activator YC-1 resulted in enhanced LTP at thalamic inputs to the LA. Interestingly, YC-1-induced enhancement of LTP in the LA was reversed by concurrent application of the MEK inhibitor U0126, suggesting that the NO-cGMP-PKG signaling pathway may promote synaptic plasticity and fear memory formation in the LA, in part by activating the ERK/MAPK signaling cascade. As a test of this hypothesis, we next showed that rats given intra-LA infusion of the PKG inhibitor Rp-8-Br-PET-cGMPS or the PKG activator 8-Br-cGMP exhibit impaired or enhanced activation, respectively, of ERK/MAPK in the LA after fear conditioning. Collectively, our findings suggest that an NO-cGMP-PKG-dependent form of synaptic plasticity at thalamic input synapses to the LA may underlie memory consolidation of Pavlovian fear conditioning, in part, via activation of the ERK/MAPK signaling cascade.     

Neurochemical mechanisms underlying amygdaloid modulation of aggressive behavior in the cat

Studies designed to determine the respective roles of substance P, excitatory amino acids, and enkephalins in amygdaloid modulation of defensive rage behavior in the cat are presented. The basic design of these studies involved three stages. In stage I, cannula electrodes for stimulation and drug infusion were implanted into medial hypothalamic or midbrain periaqueductal gray (PAG) sites from which defensive rage behavior could be elicited. Then, a stimulating electrode was implanted into a site within the medial, basal, or central nuclear complex from which modulation of the defensive rage response could be obtained. Amygdaloid modulation of defensive rage was determined in the following manner: it employed the paradigm of dual stimulation in which comparisons were made of response latencies between alternate trials of dual (i. e., amygdala = medial hypothalamus [or PAG]) and single stimulation of the hypothalamus or PAG alone. Thus, stage I established the baseline level ofmodulation (i. e., facilitation or suppression of defensive rage) in the predrug stimulation period. In stage II, a selective or nonselective receptor antagonist for a given transmitter system was administered either peripherally or intracerebrally at the defensive rage site, after which time the same dual stimulation paradigm was then repeated over the ensuing 180 min postinjection period in order to determine the effects of drug delivery upon amygdaloid modulation of defensive rage. Stage III of the study took place at the completion of the pharmacological testing phase. The retrograde axonal tracer, Fluoro-Gold, was microinjected into the defensive rage site within the medial hypothalamus or PAG, and following a 6-14 day survival period, animals were sacrificed and brains were processed for histological and immunocytochemical analyses for the neurotransmitters noted above. This procedure thus permitted identification of cells within the amygdala which were labeled retrogradely and which were also immunostained positively for substance P, excitatory amino acids, or enkephalin. For studies involving substance P, defensive rage was elicited from the medial hypothalamus and for studies examining the roles of excitatory amino acids and enkephalin, defensive rage was elicited from the PAG. In the first study, facilitation of hypothalamically elicited defensive rage was obtained with dual stimulation of the medial nucleus of the amygdala. In separate experiments, the selective NK₁ non-peptide antagonist, CP 96,345, was administered both peripherally as well as intracerebrally into the hypothalamic defensive rage sites in doses of 0.5-4.0 mg/kg (i. p.) and 0.5-2.5 nmol (i. c.). Following drug delivery, the facilitatory effects of medial amygdaloid stimulation were blocked in a dose- and time-dependent manner in which the effects were noted as early as 5 min postinjection. The maximum drug dose (4.0 mg/kg) employed for peripheral administration resulted in a 42% reduction in the facilitatory effects of the medical amygdala (P < 0.002). This drug, when microinjected directly into medial hypothalamic defensive rage sites at the maximum dose level of 2.5 nmol, resulted in an 84% reduction of the suppressive effects of amygdaloid stimulation (P < 0.5) at 5 min postinjection. In the next study, an N-methyl-D-aspartate (NMDA) antagonist, DL-α-amino-7-phosphonoheptanoic acid (AP-7), was administered either peripherally (0.1-1.0 mg/kg) or intracerebrally (0.2 and 2.0 nmol) into PAG defensive rage sites. Facilitation of defensive rage behavior, which was observed following dual stimulation of the basal amygdala and PAG, was significantly reduced by either route of drug administration in a dose- and time-dependent manner. At the maximum dose level of peripheral administration, AP-7 reduced amygdaloid facilitation of defensive rage by 63% (P < 0.001) for 60 min, postinjection. A smaller (i. e., 19%) but still significant (P < 0.05) reduction in facilitation was obtained following intracerebral administration of the drug. In a third study, the non-selective opioid receptor antagonist, naloxone (27.5 nmol), infused directly into PAG defensive rage sites, totally blocked the suppressive effects of central amygdaloid stimulation for a period of 30 min (P < 0.05) in a dose- and time-dependent manner. The anatomical phase of this study revealed the following relationships: 1) that large numbers of neurons projecting to the medial hypothalamus from the medial amygdala immunoreact positively for substance P; 2) that neurons projecting to the PAG from the basal complex of amygdala immunoreact positively for glutamate and aspartate; and 3) that neurons located within the central nucleus of the amygdala which project to the PAG immunoreact positively for met-enkephalin. Collectively, these observations provide new evidence which characterizes the likely neurotransmitters linked with specific amygdaloid pathways subserving the modulation of defensive rage behavior in the cat.     

Reliability conducive measures of coherence

A measure of coherence is said to be truth conducive if and only if a higher degree of coherence (as measured) results in a higher likelihood of truth. Recent impossibility results strongly indicate that there are no (non-trivial) probabilistic coherence measures that are truth conducive. Indeed, this holds even if truth conduciveness is understood in a weak ceteris paribus sense (Bovens & Hartmann, 2003, Bayesian epistemology. New York, Oxford: Oxford University Press; Olsson, 2005, Against coherence: Truth probability and justification. Oxford: Oxford University Press). This raises the problem of how coherence could nonetheless be an epistemically important property. Our proposal is that coherence may be linked in a certain way to reliability. We define a measure of coherence to be reliability conducive if and only if a higher degree of coherence (as measured) results in a higher probability that the information sources are reliable. Restricting ourselves to the most basic case, we investigate which coherence measures in the literature are reliability conducive. It turns out that, while a number of measures fail to be reliability conducive, except possibly in a trivial and uninteresting sense, Shogenji’s measure and several measures generated by Douven and Meijs’s recipe are notable exceptions to this rule.