Attenuation of amphetamine-stereotypy by mesostriatal dopamine depletion enhances plasma corticosterone: implications for stereotypy as a coping response

The relationship between amphetamine-induced stereotyped behavior and a neuroendocrine index of arousal, plasma corticosterone (CCS), was investigated. 6-Hydroxydopamine lesions of the caudate-putamen, which produced dopamine depletions of 60%, blocked stereotypy and prolonged the elevation in corticosterone associated with d-amphetamine treatment (5 mg/kg). Similar dopamine depleting lesions of the nucleus accumbens, which attenuated the locomotor, but not the stereotypic, response to AMPH did not have this effect on CCS. This pattern of results supports the hypothesis that stereotypy has a coping function which may serve to alter arousal and further suggests important differences between the nigrostriatal and mesolimbic dopamine projections in modulating the responsiveness of the neuroendocrine system. These results have implications for understanding the function of behavioral stereotypies common to a number of psychopathological conditions, including schizophrenia and childhood autism.     

Chest pain without coronary artery disease: An exploratory comparison with panic disorder

Recent reports have indicated similarities between patients with persistent chest pain of nonorganic origin and patients with panic disorder. In order to explore this association further, we administered a structured interview and three self-report measures (State-Trait Inventory, Beck Depression Inventory, and SCL90-R) to three subject groups: (1) a sample with persistent chest pain (CP; n=14) who had been screened and found to have normal coronary arteries, (2) a sample of patients with panic disorder (PD; n=14), and (3) a sample of matched normals (n=14). CP patients were considered to be free of coronary artery disease (CAD) following normal cardiac catheterization and/or normal thallium stress tests and were not diagnosed initially with panic disorder. PD patients were diagnosed with a standardized psychiatric interview and were free of organic causes of panic. Using an exploratory data analytic approach, the results indicated that both CP and PD samples reported increased levels of state and trait anxiety (p <.0001), depression (p <.01), and somatization (p <.0001) compared with normals. CP patients differed from PD patients in their less frequent use of anxiolytic medication (p <.01) and lower levels of reported panic anxiety and phobic avoidance (p <.0001). These data suggest that persistent chest pain in the absence of CAD shares some features with panic disorder, yet differs from panic in key ways as well. The results are discussed in light of the role of anxiety in contributing to symptom labeling.This research was supported by Grant 86G-491 from the American Heart Association, Texas Affiliate, to J.G.B. H.T. is the recipient of USPHS Research Career Development Award K04-HL-0122246.     

Age differences in the acculturation process

Age differences were assessed in a conceptual model that seeks to explain how acculturation affects psychological well-being among Mexican Americans. The data were from a national probability sample of 859 persons of Mexican decent. It was hypothesized that low acculturation creates financial stress. Moreover, low acculturation and financial stress were in turn predicted to erode feelings of personal control and self-esteem. Finally, diminished feelings of control and low self-esteem were hypothesized to exert a negative impact on psychological well-being. When data from respondents of all ages was assessed, empirical support was found for all of the hypotheses except the linkage between acculturation and financial stress. However, few age differences emerged in the model. The authors conclude that older Mexican Americans may not be more vulnerable to the stressors associated with acculturation.     

Cognitive bias and irrational belief as predictors of avoidance

Cognitive bias, i.e. overestimates of subjective probability and cost of catastrophic events, and irrational belief were explored as predictors of avoidance. Three groups-anxiety disordered clients, a mixed group of clinic outpatients, and normals--were administered several self-report inventories. Multiple regression analyses were used to investigate a modified version of the Agoraphobic Cognitions Questionnaire, the Belief Scale, and the Body Sensations Questionnaire as predictors of avoidance, as measured by the Mobility Inventory. It was hypothesized that frequency x probability x cost of catastrophic cognitions (and the occurrence of the events they represent) would be a better predictor of avoidance than frequency alone. It was also hypothesized that irrational thinking would be a significant predictor of avoidance. The results generally supported the hypotheses, with subjective probability emerging as a particularly potent predictor of avoidance. Theoretical and clinical implications are discussed.     

Qualifications and Labour-Market Outcomes among 16-Year-Old School-Leavers

Young people's qualifications are strongly related to their occupational success. It is often assumed that this can be largely accounted for by employers' selection on the basis of attainment. A variety of attainment-related attitudes and behaviour among young people which may contribute to the relationship are examined. The findings suggest that qualifications subsume a variety of behavioural factors which have an important direct effect on young people's chances in the job market.     

Developmental changes in the attribution of dispositional features

It was hypothesized (1) that with age children would rely increasingly upon information about intention, rather than overt behavior, when attributing dispositional features to others; and (2) that, developmentally, “restricted” dispositional attributions (i.e., those that assume the operation of highly specific situation-response relationships) would precede “generalized” dispositional attributions (which assume the operation of a dispositional concept between broad classes of situations and responses). An experiment is reported that provides support for the first, though not the second, of these hypotheses.     

Development and validation of the safety locus of control scale

The Safety Locus of Control Scale was designed to predict employees' accidents and injuries. Internal scorers think they should assume personal responsibility for their safety, and they believe they can take preventive steps to avoid accidents. External scorers assume little personal responsibility for prevention of accidents. Instead, they place more blame on factors outside their control, such as luck or chance. This study showed that the safety scale was effective in differentiating between groups with varying accident histories, which supports the criterion-related validity of the scale.     

Validity and reliability of the EOM-EIS for early adolescents

The Extended Objective Measure of Ego Identity Status (EOM-EIS) was examined for reliability and validity among early/middle adolescent subjects. The EOM-EIS represents a combination of the Objective Measure of Ego Identity Status and a structured interview of identity status. The instrument was designed to measure ego identity with regard to occupational, religious, political, philosophical, and social contexts along ideological and interpersonal dimensions. A total of 467 students aged 12 to 18 (median = 15.73) responded to the instrument. In general the results from the analyses of reliability, validity, demographic characteristics, and psychosocial maturity yielded results which parallel the theoretical framework and the results from college-aged subjects.