Stress is a known precipitant for metabolic and neurological diseases, with sensitive periods identified across the developmental continuum from conception to old age. However, the effects of stress may vary depending on the point or points along the developmental trajectory when adversity strikes. Past research has emphasized the consequences of stress on fully developed physiological systems in the brain and periphery, but more recent studies have explored the impact of stress on systems at different stages of maturation, with differential effects being revealed. This review provides an overview of the diverse effects of stress at critical developmental stages and the potential outcomes that may be associated with experiencing environmental adversity during ontogeny. 相似文献
This study examined the categorization processes that Alzheimer's disease (AD) patients use during assessments of semantic memory. Rule-based categorization involves the careful, analytic processing of strict criteria to determine category membership, particularly for items from graded categories with ambiguous category membership; similarity-based categorization requires an overall comparison of a test stimulus with a prototype or remembered exemplar of the category and is relatively effective for the rapid categorization of items with unambiguous category membership. To assess these processes in AD, patients were asked to decide the category membership of test stimuli for categories with poorly defined or fuzzy boundaries (e.g., VEGETABLE) and for categories with well-defined boundaries (e.g., FEMALE) and then to judge the representativeness of the test stimulus for its chosen category. A subgroup of AD patients demonstrated a typical pattern of impaired semantic memory compared to healthy control subjects; that is, difficulty deciding the category membership of test items from fuzzy categories. Among these patients, we found no deficit in category membership decisions about items taken from well-defined categories. We also found that AD patients and healthy controls do not differ in their representativeness judgments of items within a correctly judged category. These findings are most consistent with the hypothesis that rule-based categorization difficulty limits semantic memory in AD. 相似文献
Cognitive determinants of GSR activity during extinction trials were examined following conditioning. Conditioned GSRs extinguished rapidly when subjects were informed the UCS would not again be administered, compared to subjects not given this information. Of greater interest was the finding that (false) high feedback concerning subjects' responsivity to the Cs+ during extinction served to maintain GSR activity at a higher level than subjects receiving (false) low feedback. The relationship was observed within both information conditions. Implications are drawn for both aversive conditioning therapy and systematic desensitization. 相似文献
Estimates of the degree of genetic and environmental influences on religiousness have varied widely. This variation may, in part, be due to age differences in the samples under study. To investigate the heritability of religiousness and possible age changes in this estimate, both current and retrospective religiousness were assessed by self-report in a sample of adult male twins (169 MZ pairs and 104 DZ pairs, mean age of 33 years). Retrospective reports of religiousness showed little correlation difference between MZ (r=.69) and DZ (r=.59) twins. Reports of current religiousness, however, did show larger MZ (r=.62) than DZ (r=.42) similarity. Biometric analysis of the two religiousness ratings revealed that genetic factors were significantly weaker (12% vs. 44%) and shared environmental factors were significantly stronger (56% vs. 18%) in adolescence compared to adulthood. Analysis of internal and external religiousness subscales of the total score revealed similar results. These findings support the hypothesis that the heritability of religiousness increases from adolescence to adulthood. 相似文献
Twenty-four-5-year-olds and 24 7-year-olds completed two divided-visual-field tasks; one task required subjects to categorize a dot as above or below a line, whereas the other required subjects to determine whether the dot was within 3 mm of the line. There was a relative left-hemisphere advantage for the above/below task and a relative right-hemisphere advantage for the distance task. The results indicate that distinct processing subsystems compute different kinds of visuo-spatial relations as early as 5 years of age. 相似文献
This article analyses how nation states respond to religious diversity produced by migration. Drawing on research results from a comparative macro-sociological study on the incorporation of Muslims in the United Kingdom, France, and Germany, it is argued that both the claims of recognition and the modes of symbolic and organizational incorporation are shaped by varying institutional arrangements of political organization, collective identity, and religion. Yet recent convergences in the development of multicultural forms of incorporation and the inclusion of religion as a legitimate category of identity in the public sphere suggest that these institutional arrangements are equally transformed under the influence of transnational discourses of human rights. 相似文献
Patients with advanced renal failure often face considerable sociopsychological stress as a result of lifestyle changes due to the disease and its treatment. The aim of the present study is to examine the effect of the Holy Qur’an recitation on depressive symptoms in hemodialysis patients. In this clinical trial, 54 hemodialysis patients were randomized to either an experimental (n = 27) or a control (n = 27) group. Patients completed the Beck Depression Inventory-II (BDI-II) at baseline and at 1 month after the intervention. Participants in the experimental group listened to recitation of the Holy Qur’an, while those in the control group received no intervention. The mean BDI-II score at baseline was 33.6 (±6.7) for the experimental group and 29.3 (±9.0) for the control group; at the end of treatment, BDI-II scores in the experimental and control groups were 14.5 (±4.8) and 31.6 (±9.2), respectively. Results from the repeated-measures general linear model controlling for baseline differences indicated a significant treatment effect (F = 9.30, p = 0.004, Cohen’s d = 0.85). Holy Qur’an recitation has a significant effect on lowering depressive symptoms in hemodialysis patients. Holy Qur’an recitation is an easy-to-implement and cost-effective strategy that may be used to supplement the treatment of depression in this setting in Iran.