Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

The ceiling of the Church of St Ignatius and the perception of concave surfaces.

This research describes two hitherto unobserved phenomena in the frescoes of the seventeenth century architect and painter, Andrea Pozzo, painted on the vaulted ceiling of the central nave of the Church of St Ignatius in Rome. The present research also reports the results of two experimental studies on the problem of the perception of shapes projected on concave surfaces. A quantitative evaluation of the phenomena perceived from various points of observation is made by means of stimuli projected at various angles on a semicylindrical surface. The validity of the assumption of invariance, and in particular of the projective invariant called the cross-ratio, is discussed within the framework of ecological theories on perception.     

Program Context,Sensation Seeking,and Attention to Televised Anti-Drug Public Service Announcements

This study examined effects of message and program sensation value, sensation seeking, and drug use on visual attention to televised anti-drug public service announcements (PSAs) among 318 18–22-year-olds, who were placed individually in a simulated home environment with the opportunity to read from print media selections and/or watch a half-hour TV program including two presentations of the test PSA. The TV program was high or low in sensation value. High sensation seekers paid greater attention to high sensation value programming and to PSA embedded in such programming, whereas low sensation seekers paid greater attention to PSA embedded in low sensation value programs. Ongoing attention to a program may help to sustain attention to a subsequent PSA. The findings relate to an activation model of information exposure and indicate that program sensation value and sensation seeking are important factors to be considered in the placement oftelevised drug abuse prevention messages.     

Predictive laws of association in statistics and physics

In the present paper we face the problem of estimating cell probabilities in the case of a two-dimensional contingency table from a predictive point of view. The solution is given by a double stochastic process. The first subprocess, the unobservable one, is supposed to be exchangeable and invariant. For the second subprocess, the observable one, we suppose it is independent conditional on the first one.     

Depression and Suicidal Ideation After Predictive Testing for Huntington's Disease: A Two-Year Follow-up Study

The present study reports a two-year follow-up of psychological effects of predictive testing for Huntington's disease. Questionnaires assessing depression, general health, well-being, self injurious behavior, life satisfaction, and lifestyle were completed by 35 carriers and 58 non-carriers before the predictive test, and 2, 6, 12, and 24 months afterwards. Both carriers and non-carriers showed high suicidal ideation before the predictive testing. Depression scores and frequency of suicidal thoughts increased for carriers, compared to non-carriers, over time. There were no differences regarding life satisfaction or life style between carriers and non-carriers. Predictive testing was beneficial in reducing overall ill-health symptoms and increasing well-being for those initially expressing concern about Huntington's disease. The importance of assessing suicidal ideation and of continuing to provide adequate support is emphasized.     

The psychology of engagement with indigenous identities: a cultural perspective

In a questionnaire study among 124 students at Haskell Indian Nations University, the authors investigated the hypothesis that engagement with Indigenous identity--assessed along three dimensions including degree (identification scale), content (panethnic or tribal nation), and context (reservation or nonreservation)--can serve as a psychological resource for well-being and liberation from oppression. Consistent with this hypothesis, degree of identification was positively correlated with community efficacy and perception of racism. Apparently inconsistent with this hypothesis, degree of identification among students who had resided on a reservation was negatively correlated with the Social Self-Esteem subscale of the Current Thoughts Scale. Rather than evidence against the identity-as-resource hypothesis, this pattern may reflect the cultural grounding of self-esteem and tools designed to measure it.