Why Dexamethasone Poorly Penetrates in Brain

Dexamethasone poorly penetrates in brain. A tracer amount of [3H]-dexamethasone administered to adrenalectomized rats or mice is poorly retained by glucocorticoid receptors in brain, while pituitary corticotrophs containing equivalent amounts of these receptors accumulate and retain large amounts of this synthetic steroid. However, adrenalectomized mice with a genetic disruption of the multiple drug resistance (mrd1a) gene have a tenfold increase of [3H]-dexamethasone uptake in brain glucocorticoid target sites reaching levels observed in the pituitary. These data demonstrate that dexamethasone is extruded from brain by the mrd1a-encoded P-glycoproteins. The data support the concept of a pituitary site of action of dexamethasone in blockade of stress-induced ACTH release, which implies that chronic dexamethasone treatment does not replace the endogenous corticosteroids depleted from brain mineralocorticoid (MRs) and glucocorticoid receptors (GRs). Dexamethasone, therefore, causes a profound disturbance in the balance of these two receptor types in hippocampus, which is an unfavourable condition threatening the neuronal integrity of this brain structure through the expression of noxious genes.     

Intention formation induces episodic inhibition of distracting stimuli

In two experiments we show that (a) distracting stimuli are inhibited after intention formation, (b) this inhibition is episodic rather than semantic in nature, and (c) inhibition of distracting stimuli is terminated once intentions are completed. In both experiments participants were asked to form an intention to press the space bar in response to six cues (i.e. intention cues). After intention formation we measured accessibility of intention cues, of words that are semantically related to the intention cues (i.e. related cues) and of semantically unrelated words (i.e. control cues). In Experiment 1, we obtained slower responses towards related cues compared with both intention cues and control cues in a recognition task, but not in a lexical decision task. In Experiment 2, we showed that inhibition of related cues is terminated after intention completion. Together these results are consistent with theorizing that inhibition of distracting (i.e. related) stimuli is functional for completing previously formed intentions, and give insight in the nature of inhibitory processes during goal pursuit.     

Social reactions to adult crying: the help-soliciting function of tears

The authors investigated how people believe they respond to crying individuals. Participants (N = 530) read 6 vignettes describing situations in which they encountered a person who either cried or did not cry. Participants reported they would give more emotional support to and express less negative affect toward a crying person than a noncrying person. However, regression analyses revealed that participants judged a crying person less positively than a noncrying person and felt more negative feelings in the presence of a crying person than a noncrying person. The valence of the situation strongly moderated these reactions. Overall, results support the theory that crying is an attachment behavior designed to elicit help from others.     

Do self-help books help?

Advice for a happier life is found in so-called ‘self-help books’, which are widely sold in modern countries these days. These books popularize insights from psychological science and draw in particular on the newly developing ‘positive psychology’. An analysis of 57 best-selling psychology books in the Netherlands makes clear that the primary aim is not to alleviate the symptoms of psychological disorders, but to enhance personal strengths and functioning. Common themes are: personal growth, personal relations, coping with stress and identity. There is a lot of skepticism about these self-help books. Some claim that they provide false hope or even do harm. Yet there are also reasons to expect positive effects from reading such books. One reason is that the messages fit fairly well with observed conditions for happiness and another reason is that such books may encourage active coping. There is also evidence for the effectiveness of bibliotherapy in the treatment of psychological disorders. The positive and negative consequences of self-help are a neglected subject in academic psychology. This is regrettable, because self-help books may be the most important—although not the most reliable—channel through which psychological insights find their way to the general audience.     

The advice of the wise: afterthoughts about reality checking

One of the aims of this special issue on happiness advice was to assess the reality value of recommendations. All papers checked empirical indications for effectiveness, typically by inspecting whether the things advised have been found to be related to happiness in empirical research. Some limitations of this approach are that some advisers used a different definition of happiness than the papers, the papers checked the advice for present day readers, not for the contemporaries of advisers, the data that is used to check the advice is most often correlative in nature, and the papers ignored personality differences. Future research should focus on a wider range of happiness advisers, look at the interaction of the advice and individual readers and address the question of the usefulness of the advice experimentally.     

To err is human: How regulatory focus and action orientation predict performance following errors

In the current study, we hypothesize that post-error performance is influenced by individual differences in action orientation and situationally induced regulatory focus. Two experiments employing a time-pressured flanker-like task, measured participants’ dispositional action orientation and manipulated regulatory focus. As expected, accuracy of the responses following errors was reduced for all participants except for action-oriented participants in a promotion focus. The latter participants are assumed to down-regulate error-related negative affect, thereby saving resources for subsequent performance. A promotion focus is assumed to facilitate the optimal use of these resources.     

Employee identification before and after an internal merger: A longitudinal analysis

Earlier studies have shown that perceived external prestige (PEP) and communication climate influence employees' overall organizational identification. This paper presents the results of a longitudinal study into the determinants of organizational identification at two organizational levels during an internal merger. Data were collected in a university where four divisions merged into two new divisions. Respondents filled out a questionnaire on organizational identification, PEP and communication climate 4 months before the merger (T1) and 2 years after the merger (T2). Results indicate that pre‐merger identification primarily influences post‐merger identification at the same organizational level. Furthermore, the determinants of employees' overall organizational identification differ from the determinants of employees' division identification. Internal communication climate is particularly important for employees' identification with their division. PEP affects employees' identification with the overall organization. Management implications are discussed for monitoring employee identification both in times of (internal) mergers and in general.     

The association between life events and suicide intent in self-poisoners with and without a history of deliberate self-harm: a preliminary study

The associations between life events in the 12 months preceding an episode of self-poisoning resulting in hospital attendance (the index episode), and the suicide intent of this episode were compared in individuals for whom the index episode was their first, episode and in individuals in whom it was a recurrence of DSH. Results indicated a significant interaction between independent life events, repetition status, and gender in the prediction of suicide intent, the association between life events and intent being moderated by repetition status in women only. The results provide preliminary evidence to suggest the presence of a suicidal process in women, in which the impact of negative life events on suicide intent diminishes across episodes.     

Can the distress-signal and arousal-reduction views of crying be reconciled? Evidence from the cardiovascular system

Theorists have staked out two ostensibly opposing views of human crying as either an arousing behavior that signals distress or a soothing behavior that reduces arousal after distress. The present study examined whether these views of crying might be reconciled by attending to physiological changes that unfold over crying episodes. Sixty female students watched neutral and cry-eliciting films while autonomic physiology, including respiratory sinus arrhythmia and pre-ejection period, was assessed. Crying participants exhibited heart rate increases that rapidly subsided after crying onset. Crying onset was also associated with increases in respiratory sinus arrhythmia and slowed breathing. All crying effects subsided by 4 minutes after onset. It is possible that crying is both an arousing distress signal and a means to restore psychological and physiological balance, depending on how and when this complex behavior is interrogated.     

Demographic, criminal, and psychiatric factors related to inmate suicide

A review of 19 studies suggests that it may be feasible to identify prisoners with suicide risk on the basis of demographic, psychiatric, and criminal characteristics. The present study aimed to identify combinations of characteristics that are capable of identifying potential suicide victims. Characteristics of 95 suicide victims in the Dutch prison system were compared with those of a random sample of 247 inmates in ten jails. Combinations of indicators for suicide risk were also tested for their capability of identifying 209 suicides in U.S. jails and 279 prison suicides in England and Wales. A combination of six characteristics (age 40+, homelessness, history of psychiatric care, history of drug abuse, one prior incarceration, violent offence) was capable of correctly classifying 82% of the Dutch suicide victims (82% specificity). Less powerful combinations correctly classified 53% of the U.S. suicides and 47% of the U.K. suicides. It is concluded that a set of demographic and criminal characteristics and indicators of psychiatric problems is useful for the identification of suicide risk in jails and prisons.