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91.
In this article, a nonlinear structural equation model is introduced and a quasi-maximum likelihood method for simultaneous estimation and testing of multiple nonlinear effects is developed. The focus of the new methodology lies on efficiency, robustness, and computational practicability. Monte-Carlo studies indicate that the method is highly efficient and that the likelihood ratio test of nonlinear effects is robust and outperforms alternative testing procedures. The new method is applied to empirical data of middle-aged men, where a latent interaction between physical fitness and flexibility in goal adjustment on complaint level is hypothesized. A model with 5 simultaneous nonlinear effects is analyzed, and the hypothesized interaction is quantified and tested positively against an additive model with quadratic and linear effects. 相似文献
92.
The heterogeneous growth curve model (HGM; Klein &; Muthén, 2006) is a method for modeling heterogeneity of growth rates with a heteroscedastic residual structure for the slope factor. It has been developed as an extension of a conventional growth curve model and a complementary tool to growth curve mixture models. In this article, a robust version of the heterogeneous growth curve model (HGM-R) is presented that extends the original HGM with a mixture model to allow for an unbiased parameter estimation under the condition of nonnormal data. In two simulation studies, the performance of the method is examined under the condition of nonnormality and a misspecified heteroscedastic residual structure. The results of the simulation studies suggest an unbiased estimation of the heterogeneity by the HGM-R when sample size was large enough and a good approximation of the heteroscedastic residual structure even when the functional form of the heteroscedasticity was misspecified. The practical application of the approach is demonstrated for a data set from HIV-infected patients. 相似文献
93.
Lea R. Dougherty Victoria C. Smith Thomas M. Olino Margaret W. Dyson Sara J. Bufferd Suzanne A. Rose Daniel N. Klein 《Journal of abnormal child psychology》2013,41(4):531-542
Neuroendocrine dysfunction is hypothesized to be an early emerging vulnerability marker for depression. We tested whether the main and interactive effects of maternal psychopathology and early child temperamental vulnerability for depression assessed at age three predicted offspring’s basal cortisol function at age 6 years. 228 (122 males) children participated in the baseline and follow-up assessments. At age three, maternal lifetime psychopathology was assessed with a diagnostic clinical interview, and child temperamental positive affectivity (PA) and negative affectivity (NA) were assessed using laboratory observations. At age six, children’s waking and evening cortisol were assessed on 2 days. Maternal lifetime anxiety predicted offspring’s higher morning cortisol at age six. Child temperamental NA at age three predicted higher evening cortisol at age six. There was a significant interaction between maternal lifetime depression and child temperamental PA at age three in predicting offspring’s morning cortisol at age six. For the offspring of mothers with lifetime depression, higher PA at age 3 predicted lower morning cortisol at age 6. These findings highlight the importance of examining the main and interactive effects of maternal psychopathology and early child temperamental vulnerability in predicting the development of offspring’s stress physiology. Findings hold significance in identifying etiological mechanisms of risk and delineating the complex developmental pathways to psychopathology. 相似文献
94.
Alexandria Meyer Greg Hajcak Dana C. Torpey Autumn Kujawa Jiyon Kim Sara Bufferd Gabrielle Carlson Daniel N. Klein 《Journal of abnormal child psychology》2013,41(8):1257-1266
Anxiety disorders are the most frequently diagnosed form of psychopathology in children and often result in chronic impairment that persists into adulthood. Identifying neurobehavioral correlates of anxiety that appear relatively early in life would inform etiological models of development and allow intervention and prevention strategies to be implemented more effectively. The error-related negativity (ERN), a negative deflection in the event-related potential at fronto-central sites approximately 50 ms following the commission of errors, has been consistently found to be larger among anxious adults. The current study sought to extend these findings to even younger individuals: the ERN was elicited by a Go/NoGo task in 48 six year-old children with a clinical anxiety disorder assessed by diagnostic interview and 48 age-matched controls. In addition to child anxiety disorder, the ERN was examined in relation to maternal history of anxiety disorder, which was previously related to a smaller ERN. Anxious children were characterized by a larger (i.e., more negative) ERN and maternal history of anxiety disorder was associated with a smaller ERN. Thus, the relationship between an increased ERN and clinical anxiety is evident by age 6, and this effect appears independent from an opposing influence of maternal anxiety history on the ERN. These findings support the ERN as a promising neurobehavioral marker of anxiety, and implications are discussed. 相似文献
95.
Helmut Hildebrandt Frauke Fink Paul Eling Heiner Stuke Jan Klein Markus Lentschig Andreas Kastrup Christiane Thiel Thomas Breckel 《Brain and cognition》2013
Introduction
Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.Methods
We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.Results
fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.Conclusion
With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus). 相似文献96.
Audrey A. Klein Justin J. Anker 《Journal of psychopathology and behavioral assessment》2013,35(2):205-214
Despite research suggesting that alcohol-dependent individuals have both craving and avoidant tendencies for alcohol, few studies have measured self-report tendencies using the Approach and Avoidance of Alcohol Questionnaire (AAAQ). The goal of this study was to examine the psychometric properties of the AAAQ using a sample of adults receiving 12 step-based residential treatment for alcohol dependence. As part of a larger study, 100 adults receiving residential treatment completed the AAAQ and several other assessments shortly after treatment admission. Analyses of the AAAQ examined its factor structure, internal consistency, and convergent and predictive validity. A maximum likelihood estimation factor analysis using oblique rotation produced 3 factors accounting for 69 % of the variance. A confirmatory factor analysis suggested that the 3-factor model was a moderate fit for data from a second sample of patients. Internal consistency was fairly high and convergent validity was demonstrated by relationships with another scale of alcohol craving, time since last drink, and quantity and frequency of pre-treatment alcohol use. Regarding predictive validity, the level of approach tendencies on the AAAQ was significantly related to abstinence status during the first 6 months following treatment. Avoidance level was not related to abstinence. The results largely replicated past studies utilizing outpatient samples and suggest that the AAAQ shows promise as a psychometrically sound, internally reliable self-report craving measure for individuals with alcohol dependence. 相似文献
97.
98.
The origin of the rapid hardening which occurs during the initial ageing stage of an Al-1.7 at.% Mg-1.1 at.% Cu alloy has been investigated by the threedimensional atom-probe (3DAP) and transmission electron microscopy techniques. Although the rapid hardening reaction occurs within 1 min at 150 degrees C, no evidence for solute clusters or Guinier-Preston-Bagaryatsky (GPB) zones was detected using the 3DAP after this ageing time. When a short-term aged specimen is deformed and then aged at 150 degrees C, further rapid hardening occurs. This suggests that the rapid hardening is associated with a solutedislocation interaction. Uniform dispersions of Cu-Mg co-clusters do not occur until closer to the end of the hardness plateau and it is thought that these evolve into GPB zones during the second stage of the age-hardening process. 相似文献
99.
The current study examined the robustness, stability, reliability, and isolability of the attention network scores (alerting, orienting, and executive control) when young children experienced repeated administrations of the child version of the Attention Network Test (ANT; Rueda et al., 2004). Ten test sessions of the ANT were administered to 12 young children. Participants were asked to indicate the direction of a target fish, flanked by distractors, presented either above or below the fixation cross following different types of visual cues. Network scores, reflecting alerting, orienting, and executive control, were calculated using orthogonal subtractions of performance in selected conditions. Only the alerting network scores remained highly significant across the 10 sessions. The executive network scores showed some practice effects. The reliability of the network scores remained poor regardless of the amount of data. Based on the results, use of the ANT is cautioned against in young children when repeated testing is required. 相似文献
100.
Esther S. Klein 《Dao》2013,12(2):207-224
This article explores the connection between the Heng Xian and the Changes of Zhou tradition, especially the “Tuan” and “Attached Verbalizations” commentaries. Two important Heng Xian terms—heng 恆 and fu 復—are also Changes of Zhou hexagrams and possible connections are explored. Second, the Heng Xian account of the creation of names is compared with the “Attached Verbalizations” account of the creation of the Changes of Zhou system. Third, the roles played by knowing and desire in both Heng Xian and the Changes of Zhou tradition are explored, with particular focus on potential points of similarity. Finally, insights gained through these comparisons are used to interpret the Heng Xian advice on initiating action. 相似文献