Impact of Institutional Review Boards on cancer research

The concepts of informed consent and surveillance of human research designed to protect human subjects is commendable. The regulations of the Institutional Review Board (IRB) are having a major impact on clinical cancer research. There is greater administrative time needed of the investigator, the mechanisms of patient care have become cumbersome and some patients reject optional medical management that could be life saving. IRB regulations must be flexible to meet the needs of human subjects as well as those of the clinical investigator.     

Automatic monitoring of temperature and/or location: A computer-controlled radiotelemetry system

A radiotelemetry system for continuous monitoring of the temperature and/or location of small animals is described. All the functions of system control are carried out by an on-line microcomputer (TRS-80 Model III), resulting in a versatile system capable of alternating recording the temperature/location of multiple subjects with other behavioral or physiological events, such as activity level. We describe the use of this system in monitoring body temperature in hamsters and in recording the incubation pattern of breeding ring doves.     

An analysis of some sensitizing agents in the pathogenesis of stress-induced gastric erosive disease

Prior surgical implantation of a venous catheter sensitized rats to coldimmobilization stress. Three of six catheterized females succumbed during the stress. The remaining rats fell into two groups in terms of their core temperature at the end of the stress period: Male uncatheterized rats had higher temperatures than rats in the other three groups. No relation was found between catheter patency and magnitude of hypothermia. Degree of gastric disease paralleled the core temperature findings in that the male uncatheterized rats had significantly fewer gastric erosions than the rats in the other three groups. Additionally, a robust effect of gender was found with uncatheterized females showing more hypothermia and more gastric disease than uncatheterized males. A subsequent experiment was conducted to evaluate whether anesthesia or wearing the protective spring was responsible in part for the sensitization seen. Here, the gender difference was less although females consistently averaged lower core temperatures after stress than did males. Despite similar core temperatures after stress, females that were prepared with the protective spring apparatus developed more gastric disease than female controls or similarly treated males. Thus, the additional sensitization exhibited by females in the first experiment may relate to the fact that both catheterization and the taping procedure were sensitizers while only catheterization was a sensitizer for males.     

Relationships between adolescent drug use and parental drug behaviors

The present study examined some previously reported relationships between drug use by adolescents and perceived attitudes and behaviors of their parents. An anonymous questionnaire was administered to the student body of an inner-city secondary school for difficult students. Relationships between parental use of drugs and adolescent use of the same drugs were moderate and roughly equivalent across drugs. However, parental use of marijuana was strongly related to the adolescent's use of other, harder drugs such as opiates, cocaine, amphetamines, and barbiturates. This finding is explained within the framework of Kandel's postulated stages of drug initiation. It points to a need for further study of parental influences, which may be increasingly problematic as more individuals who have grown up in our marijuana-accepting society become parents of adolescents.     

Attentional strategies and the visual control of discrete movements

The relationship between the availability of visual information and attention demands during the production of a discrete motor act was examined. Subjects were required to move a linear slide a distance of 15 cm in both 150 and 600 msec conditions under three light manipulations, viz., light always on; light always terminated as movement began; or, subject was unsure as to whether light would stay on or terminate. A simple key press by the index finger of the opposite hand to a tone was used as a secondary task and a measure of attention demands. The light manipulation influenced attention demands on the rapid 150 msec movement such that more attention was demanded when the subject knew the light would terminate. No such attentional strategy differences were found with the slow 600 msec movement. These findings suggest that task constraints in the form of kinematic criteria, together with the perceived availability of visual information, contribute to determining attentional strategy in movement production.     

The relationship of self and occupational concepts to the occupational preferences of adolescents

This study tested aspects of Super's self-concept theory of career development with a sample of British schoolchildren. Findings suggested that self-concepts and concepts of occupational preferences do have a role in career development, though there were some indications that the theory is more applicable to more able youngsters and to those high in self-esteem, than to others. Agreement between ideal-self-concepts and occupational preference concepts was significantly greater than that between actual-self-concepts and occupational preference concepts. This finding was interpreted as reflecting the youngsters' greater concern for the future and the possible, rather than the present and the given, and it suggested that refinements are needed in Super's theory.     

The end phase of analysis: indicators, functions, and tasks of termination

This paper considers the end phase of analysis. Beginning with a brief review of the literature on termination, specifically the indicators for initiating the termination process, we identify the structural attainments necessary for the patient to successfully complete the analysis and to maintain smooth post-analytic functioning. We stress in this regard the significance of self-analytic functions and the relative immutability of the transference neurosis. These points are illustrated with clinical examples. Our paper concludes with a discussion of the tasks and contributions of the analyst during the termination process. We make special reference to countertransference vulnerability resulting from the analyst's own termination experiences.