大学生心理健康因素分析

大学生的心理健康问题与新时代社会发展有密切关系．他们的心理特点带有强烈的时代色彩。大学新生与毕业生的心理需求不同,所产生的心理障碍也不同,但通过心理咨询和心理健康教育,可以在很大程度上使学生们保持心理健康。     

Entorhinal cortical Island cells regulate temporal association learning with long trace period

Temporal association learning (TAL) allows for the linkage of distinct, nonsynchronous events across a period of time. This function is driven by neural interactions in the entorhinal cortical–hippocampal network, especially the neural input from the pyramidal cells in layer III of medial entorhinal cortex (MECIII) to hippocampal CA1 is crucial for TAL. Successful TAL depends on the strength of event stimuli and the duration of the temporal gap between events. Whereas it has been demonstrated that the neural input from pyramidal cells in layer II of MEC, referred to as Island cells, to inhibitory neurons in dorsal hippocampal CA1 controls TAL when the strength of event stimuli is weak, it remains unknown whether Island cells regulate TAL with long trace periods as well. To understand the role of Island cells in regulating the duration of the learnable trace period in TAL, we used Pavlovian trace fear conditioning (TFC) with a 60-sec long trace period (long trace fear conditioning [L-TFC]) coupled with optogenetic and chemogenetic neural activity manipulations as well as cell type-specific neural ablation. We found that ablation of Island cells in MECII partially increases L-TFC performance. Chemogenetic manipulation of Island cells causes differential effectiveness in Island cell activity and leads to a circuit imbalance that disrupts L-TFC. However, optogenetic terminal inhibition of Island cell input to dorsal hippocampal CA1 during the temporal association period allows for long trace intervals to be learned in TFC. These results demonstrate that Island cells have a critical role in regulating the duration of time bridgeable between associated events in TAL.

The linkage of temporally discontiguous events, called temporal association learning (TAL), is an essential function for episodic memory formation; for animals, when an event took place, and in what order a series of events occurred is directly linked to adaptation to continuous changes in the environment (Eichenbaum 2000; Tulving 2002a,b; Kitamura et al. 2015a; Kitamura 2017; Pilkiw and Takehara-Nishiuchi 2018). The entorhinal cortical–hippocampal (EC-HPC) network in particular is currently considered to bridge the temporal discontinuity between events (Solomon et al. 1986; Moyer et al. 1990; Wallenstein et al. 1998; McEchron et al. 1999; Eichenbaum 2000; Huerta et al. 2000; Ryou et al. 2001; Takehara et al. 2003; Chowdhury et al. 2005; Esclassan et al. 2009; Morrissey et al. 2012; Suter et al. 2013; Sellami et al. 2017; Wilmot et al. 2019).Two major excitatory inputs to HPC arise from the superficial layers of the EC (Fig. 1A), forming the direct (monosynaptic), and indirect (trisynaptic) pathways (Amaral and Witter 1989; Amaral and Lavenex 2007; Kitamura 2017; Kitamura et al. 2017). While pyramidal cells in EC layer III (ECIII cells) project directly to CA1 (Kohara et al. 2014; Kitamura et al. 2015b), the trisynaptic pathway originates from excitatory Reelin⁺ stellate cells in EC layer II (ECII) projecting directly to DG, CA3, and CA2 (Fig. 1B; Tamamaki and Nojyo 1993; Varga et al. 2010). CalbindinD-28K⁺/Wolfram syndrome 1 (Wfs1)⁺ pyramidal cells, another excitatory neural population in EC layer II called “Island cells,” form cell clusters along the ECII/ECI border (Alonso and Klink 1993; Fujimaru and Kosaka 1996; Klink and Alonso 1997; Kawano et al. 2009; Varga et al. 2010; Kitamura et al. 2014; Ray et al. 2014) and directly project to the GABAergic interneurons of stratum lacunosum (SL-INs) in HPC CA1 and drive feedforward inhibition to HPC CA1 pyramidal cells (Fig. 1B; Kitamura et al. 2014; Surmeli et al. 2016; Kitamura 2017; Ohara et al. 2018; Yang et al. 2018; Zutshi et al. 2018).Open in a separate windowFigure 1.Circuit schematic diagram of the medial entorhinal cortex (MEC)–hippocampal (HPC) circuit. (A) Major projections in the entorhinal cortical (EC)-HPC network. ECIII neurons (green) project directly to CA1. ECII Ocean cells (ECIIo, purple) project to the dentate gyrus (DG) (light blue)/CA3 (pink) initiating the trisynaptic pathway. ECII Island cells (ECIIi, blue) project directly into CA1. (B) ECIII projections (green) excite the distal portions of CA1 pyramidal cell (yellow) dendrites in the stratum moleculare. Island cells (ECIIi, blue) excite the interneurons of stratum lacunosum (SL-INs, red), which in turn inhibit the distal dendrites of CA1 pyramidal cells in SL.Trace fear conditioning (TFC) has been established as one suitable animal model for TAL (Fendt and Fanselow 1999; Maren 2001; Kim and Jung 2006) that can be also used as a translational bridge between animal and human learning (Clark and Squire 1998; Buchel and Dolan 2000; Delgado et al. 2006). Lesion, pharmacological, molecular, and optogenetic manipulation, as well as disease models in medial entorhinal cortex (MEC), demonstrate that MEC is crucial for TFC and temporal learning (Ryou et al. 2001; Woodruff-Pak 2001; Runyan et al. 2004; Esclassan et al. 2009; Gilmartin and Helmstetter 2010; Suh et al. 2011; Morrissey et al. 2012; Shu et al. 2016; Hales et al. 2018; Yang et al. 2018; Heys et al. 2020). Specifically, MECIII inputs into the HPC CA1 pyramidal cells are essential for the formation of TFC (Yoshida et al. 2008; Suh et al. 2011; Kitamura et al. 2014; Kitamura 2017). However, the temporal association function driven by MECIII neurons must be regulated for optimal adaptive memory formation, as too strong an association of a particular pair of events may interfere with associations of other useful pairs, whereas too weak an association for a given pair of events, in terms of weaker impact of events or longer duration of temporal gap between events, would not result in an effective memory (Kitamura et al. 2015a; Marks et al. 2020). In a naturalistic context, this would mean that more distant/quieter sounds, less intense somatic sensations (e.g., pain), or increased temporal distance between any two events would signal that the events are less likely to be causally associated, therefore less relevant, and less likely to be stored and recalled. In fact, successful TFC depends on the strength of event stimuli and duration of temporal gap between events (Stiedl and Spiess 1997; Misane et al. 2005; Kitamura et al. 2014; Kitamura 2017). However, the underlying regulatory mechanism for TAL remains hidden. Previously we demonstrated that feedforward inhibition by Island cells acts as a gating controller for the MECIII inputs to the distal dendrites of HPC CA1 pyramidal cells in stratum moleculare (SM) (Kitamura et al. 2014) to control TFC when weaker (in this case diminished footshock intensity) unconditioned stimuli were delivered for TFC, indicating that Island cell activity controls the temporal association when the strength of two discontinuous events are relatively weaker. However, the way in which the EC-HPC network regulates TFC with a longer trace period still remains unknown. Because the activation of Island cells would result in a net inhibitory effect on the local network in CA1, imposing a tight and specific regulation on associations of events across the temporal gap in TAL (Crestani et al. 2002; Moore et al. 2010; Kitamura et al. 2014, 2015b), we hypothesized that the length of the temporal gap between events would also be modulated by this mechanism. In this study, we examined the role of the regulatory input to this circuit arising specifically from the Island cells in the MECII using apoptotic elimination of Island cells, chemogenetic neural inhibition, and optogenetic terminal inhibition methods within an L-TFC protocol to give a thorough and complete assessment of the circuit involvement while considering each technique''s unique features.     

工作记忆训练提升幼儿流体智力表现

目前已有许多研究证据表明, 工作记忆训练能提高成人、儿童的流体智力成绩, 然而这种训练是否能够提高幼儿的流体智力表现, 更为重要的是, 如果训练确有成效, 那么这种训练效果能否长期保持？为此, 本研究选择了幼儿园4~5岁幼儿进行工作记忆训练任务, 考察工作记忆训练对流体智力的提升及保持效应。实验中设立3个组：实验组、控制1组和控制2组。实验组采用单个空间n-back的工作记忆游戏程序进行训练, 控制1组采用“水果忍者”的游戏程序进行训练, 两组进行游戏训练的时间均为14天, 每天15 min; 控制2组不进行任何训练。结果发现, 训练后实验组幼儿被试的流体智力成绩明显优于两个控制组, 在6个月后再进行测试, 这种优势仍然保持。本研究结果表明, n-back工作记忆训练可以提高幼儿的流体智力成绩, 并且这种训练效果具有持续的稳定性。     

音乐时间加工的影响因素

音乐的时间维度在音乐艺术中具有重要的作用。已有研究表明, 对音乐时间维度的加工受制于许多方面, 一方面, 音乐构成要素的特征影响着人们对音乐时间的加工; 另一方面, 听者的年龄、注意、工作记忆、音乐训练以及对音乐的熟悉性等因素也影响着他们对音乐时间加工的深度和广度。未来的研究应进一步确定音乐时间加工的影响因素及其相对重要性, 并对音乐时间加工中基因与环境的关系以及发展的敏感期等问题进行研究。     

非熟练潮-粤双言者的语义通达：来自听觉词加工的证据

采用听觉跨语言启动的语义判断范式, 考察非熟练潮-粤双言者的两种方言之间的语义通达方式。结果发现, 无论是以潮语词为启动词, 还是以粤语词为启动词, 当二者具有翻译关系时, 启动词均促进对目标词的识别, 但L1对L2的启动量比L2对L1的启动量大。当启动词与目标词具有语义联想关系时, 启动词亦能促进对目标词的识别, 但L1→L2与L2→L1的启动量差异不显著。整个研究表明, 非熟练潮-粤双言者的两种方言的词汇独立表征, 语义共享表征; 第二方言的词汇能够直接通达语义表征, 不需要以第一方言的词汇为中介, 但双言的词汇表征与语义表征的联结强度仍然存在着不对称性。     

小学生学习坚持性和学习投入在效能感、内在价值与学业成就关系中的中介作用*

采用学习坚持性问卷、自我效能感问卷、内在价值问卷和学习投入量表,对407名四、五年级小学生施测,并收集学生期中考试成绩作为客观指标,建立结构方程模型以考察学习坚持性和学习投入在自我效能感、内在价值与学业成就关系中的中介作用。结果发现:(1)学习坚持性与自我效能感、内在价值、学习投入、学业成就均显著正相关;(2)学习坚持性可以部分中介自我效能感与学习投入、内在价值与学习投入之间的相关;(3)学习坚持性通过学习投入的中介作用影响学业成就。     

5-HTTLPR、性别、家庭社会经济地位与面孔表情识别的关系

该研究采用531名中国汉族健康大学生为被试,综合考察了5-HTTLPR(5-羟色胺转运体基因连锁多态区)基因型、性别和家庭社会经济地位之间交互作用与面孔表情识别的关系。研究结果发现,性别和家庭社会经济地位在面孔表情识别上有显著的主效应。总体来说,家庭社会经济地位较高和女性的被试具有较好的面孔表情识别能力。5-HTTLPR基因型、性别、家庭社会经济地位,它们在面孔表情识别上的三因素交互作用也显著。该三因素交互作用主要是源于,在高家庭社会经济地位背景下,女性携带有5-HTTLPR长片段等位基因比短片段纯合子表现出稍差的面孔表情识别能力。该结果体现了基因与环境多因素交互作用对面孔表情识别能力的重要性。     

东方人在不道德行为之后会做些什么

道德情绪对个体的行为模式具有重要的影响。本文通过唤起个体的不道德情绪(或道德情绪),然后分别对其进行字词偏好、物品选择和颜色喜好等测验,来探讨东方人在不道德情绪状态下会产生什么行为。结果发现：处于不道德情绪状态下的个体,对含有掩饰意义的行为动作、物品具有心理和行为上的接近性,且经过掩饰行为(整理动作)之后,这些个体对白色就产生了一定程度的偏好,而无整理动作(休息)的个体则更偏爱黑色。这表明,不同于西方个体的道德洁净行为,东方人身上出现的是一种道德掩饰行为。     

工科院校大学生人格和人际交往特点与网络成瘾的关系研究

采用中国大学生人格量表(CCSPS)、自编的大学生人际交往能力量表和Young的网络成瘾量表,研究工科院校大学生人格、人际交往特点与网络成瘾倾向的关系.发现:大学生人际交往能力的高低对其网络成瘾倾向有预测作用;大学生人格特质大中的活跃、坚韧、严谨、利他、重情维度与网络成瘾倾向呈显著相关,其中,人格的活跃、坚韧、严谨、重情维度有预测作用.     

不同性质汉语否定句心理加工过程的实验研究

采用词汇/图片判断范式,以不同性质的否定句和其对应的肯定句为实验材料,以词汇/图片判断的反应时和正确率为因变量指标,探讨不同性质汉语否定句的加工是否是动态变化的过程。研究分为两个大实验四个小实验。实验一采用句图匹配任务,否定句是对具体现实情境的否定,实验1a和1b分别考察句图短时间间隔和长时间间隔下否定意义的加工。实验二采用词汇判断任务,实验材料为隐喻形式的否定句。实验2a和2b分别为句词短时间间隔和长时间间隔。实验1发现短时间间隔时,句图不匹配条件下图片判断时间短于匹配时;长时间间隔时相反,句图匹配条件下图片判断时间更短。实验2发现短时间间隔时,句词不匹配条件下词汇判断时间短于匹配时,而长时间间隔时匹配与否的词汇判断时间无差异。综合两个实验结果表明,对现实情境的具体否定句符合两阶段模拟加工,被否定意义在加工早期被表征,但会因句子实际意义的通达而得到抑制;而隐喻形式的抽象否定句加工更符合抑制/保存假说,被否定意义在加工早期被表征,并在加工后期仍保留在头脑中。