Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins

Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins used to color food (E163), has been reported to possess a variety of biological activities, including anti-oxidant, anti-tumor, and anti-inflammatory. The effect of PSPC on the spatial learning and memory of mice treated with d-galactose (d-gal) was evaluated by the Morris water maze; d-gal-treated mice had decreased performance compared with mice in the vehicle and PSPC groups, while the PSPC + d-gal group showed significantly shortened escape latency to platform, increased swimming speed, more target quadrant search time and more platform crossings as compared with the d-gal group. Brain functions, such as memory formation and recovery of function after injury, depend on proper regulation of the expression levels of the pre- and post-synaptic proteins. We investigated the expression of four pre-synaptic proteins (growth-associated protein-43, synapsin-I, synaptophysin, and synaptotagmin) and two post-synaptic proteins (post-synaptic density protein-95 and Ca²⁺/calmodulin-dependent protein kinase II) in the hippocampus and cerebral cortex, respectively, in response to different treatments. Western blotting analysis showed that there were significant decreases in the expression of these representative synaptic proteins in the hippocampus and cerebral cortex of d-gal-treated mice. Interestingly, these decreased expression levels of synaptic proteins could be reversed by PSPC. The levels of expression of these representative synaptic proteins in mice treated with PSPC alone were not significantly different from those in untreated mice. The results of this study suggested that memory impairment and synaptic protein loss in d-gal-treated mice may be improved by treatment with PSPC.     

脉压差变化对预测心血管疾病的研究进展

心血管疾病严重威胁人类的生命安全及身心健康,脉压差作为预测心血管疾病的指标近年来也颇受重视,研究结果显示：脉压差和冠心病的发病率呈显著正相关,脉压差升高是动脉硬化及心血管病高危的一个标志,它的作用大于舒张压甚至超过收缩压;提示：脉压差是心血管疾病的一个良好的预测因子,也是反映中老年人血管硬化的一个较好的指标。     

内科临床实习医师的带教思考

针对新形势下教学医院内科实习医生的特点,从教学方法、医学模式转变、能力培养、实习管理、医惠关系和医德教育以及就业指导等6个方面进行了分别阐述,强调了教学实习的新特点、新任务,主张教师的角色转换,真正实行弹性化管理,从而达到最佳的实习效果。     

肾移植术后糖尿病临床高危险因素分析

探讨移植后糖尿病发生的高危因素。116例受者分为糖尿病组（22例）和非糖尿病组（94例）。对可能危险因素进行χ^2检验后显示术前肝功、糖耐量正常、术后用小量激素、CSA方案并血药浓度正常的患者糖尿病发生率低于相对应组,而性别、年龄、糖尿病家族史相比,P〉0．05。说明肝功能、糖耐量、激素量、免疫抑制剂及药物浓度是移植后糖尿病发生的危险因素。     

中医学防治亚健康的机制与方法研究

随着传统医学模式的转变,亚健康状态的研究已经成为当今医学的热点。但由于其系统研究的不足,亚健康状态产生与治疗机制尚未明确,在亚健康的治疗上仍然存在许多困难和未知。总结了中医学对亚健康状态的防治机制,提出了亚健康状态的治疗原则和防治方法。     

姑息治疗及其在肿瘤学中的地位

本文对姑息治疗的历史及概念作了详细的介绍,解释了其不同阶段的内涵,作为医学学科之一,姑息治疗的内容主要包括了疾病伴随或治疗所致症状的诊断评估、预防和治疗,心理和非癌性躯体疾病的预防和治疗,姑息治疗的科研、教学和教育以及终末期病人的治疗和护理等,特别纠正了对“安乐死”的看法。在肿瘤学中,经过40多年,它已从治疗中的辅助角色迅速成为肿瘤综合治疗中的主角,且贯穿于始终。它倡导多学科协作,与抗癌治疗完整结合,对无法治愈的晚期癌症患者以缓解症状、改善生活质量为主要目标,在全球范围内,很大一部分晚期肿瘤病人已从姑息治疗中明显获益。它的有力实施,也是我们创建和谐社会的重要反映。     

脑死亡立法的艰难与中国传统文化

因中国传统伦理文化对人们意识观念的深刻影响导致中国脑死亡立法步履艰难。从中国传统文化视角分析中国的脑死亡及相关伦理问题,提出中国脑死亡诊断标准的制定必须充分考虑民族心理感受,要立足于民族文化理性地探索“中国脑死亡”。     

高校教师生活压力的研究

本研究采用因素分析法研究了广东高校教师的生活压力。结果表明 ,高校教师的生活压力来自家庭生活、发展提高、人际关系、工作性质、工作冲突以及兴趣和满意感等 6个方面