Genetic Counseling Considerations in the Evaluation of Families for Lynch Syndrome��A Review

Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition.     

The role of strategies in deciding advantageously in ambiguous and risky situations

In decision situations of everyday life, the potential positive or negative consequences of a decision are often specified and the associated probabilities are known or they are principally calculable ("decisions under risk"). On the basis of correlations reported in patient studies, it has been recently proposed that decisions under risk involve strategic components, i.e. calculation of the risk, as well as emotional processes, i.e. processing feedback from previous decisions. However, the potential impact of calculative strategies on decision-making under risk has not been investigated systematically, so far. In the current study, we examined 42 healthy subjects (21 females) with the Game of Dice Task measuring decisions under risk, and a questionnaire assessing strategy application in items comparable to the choices in the Game of Dice Task. In addition, the subjects performed the Iowa Gambling Task, examining decision-making under ambiguity, and a neuropsychological test battery focusing on executive functions. Results indicate that deciding advantageously in a decision-making task with explicit and stable rules is linked to applying calculative strategies. In contrast, individuals who decide intuitively prefer risky or disadvantageous choices in the Game of Dice Task. Applying calculative strategies was correlated with executive functions but not with performance on the Iowa Gambling Task. The results support the view that calculative processes and strategies may improve decision-making under explicit risk conditions.     

Internet Versus Group Cognitive-Behavioral Treatment of Distress Associated With Tinnitus: A Randomized Controlled Trial

Tinnitus distress can be reduced by means of cognitive-behavior therapy (CBT), and the treatment can be delivered in different ways. The most recent format is Internet-based self-help. The aim of this study was to compare this treatment (n = 26) with standard group-based CBT (n = 25) in a randomized controlled trial. Outcomes on self-report inventories measuring tinnitus distress were evaluated immediately after and 1 year after treatment. Results showed that both groups had improved, and there were few differences between them. The effect size for the Internet treatment was d = 0.73 (95% CI = 0.16–1.30) and for the group treatment was d = 0.64 (95% CI = 0.07–1.21). The Internet treatment consumed less therapist time and was 1.7 times as cost-effective as the group treatment. At pretreatment patients rated the Internet treatment as less credible than the group treatment. In conclusion, Internet treatment for tinnitus distress merits further investigation, as the outcomes achieved are promising.     

Reorientation in the real world: the development of landmark use and integration in a natural environment

An influential series of studies have argued that young children are unable to use landmark information to reorient. However, these studies have used artificial experimental environments that may lead to an underestimation of the children’s ability. We tested whether young children could reorient using landmarks in an ecologically valid setting. Children aged between 3 and 7 years completed a reorientation task in open parkland, and the properties of the search array (size and distinctiveness) were manipulated in a within-subjects design. Responses were recorded using Global Positioning Systems technology. All age groups performed above chance level, demonstrating that young children can reorient using natural landmarks. This behaviour was modulated by the nature of the search array: children were more accurate when the locations were spaced in a large array, and when the search locations were distinctively coloured. This suggests that the integration between landmarks and search locations, at different spatial scales, is a key factor in characterising human reorientation in the real world.     

Queuing Among U2 Fans: Reactions to Social Norm Violations1

Two experiments examined reactions to line‐intrusion scenarios among fans of the rock group U2 waiting in overnight lines to obtain desirable concert floor spots. Commitment to the goal, time investment, and ambiguity of the line‐intrusion scenario were examined. Results showed that the queue is a social system influenced by norms of procedural justice (first‐come, first‐served). Violations of these norms were upsetting, even when the consequences did not directly influence personal outcomes (when line intrusions occurred behind a subject). Greater commitment to the goal led to more severe reactions to norm violations, whether the commitment was proximal (having waited in the line for awhile) or distal (being a committed fan). We discuss research on social norm violations.     

On use of student samples for scale construction

This research note responds to the question of whether a convenience sample of undergraduate students may be successfully utilized in concept development and in scale construction, and in what way the results are comparable to the findings of a representative national sample. The results of a Mokken analysis in both samples support the hypothesis that convenience samples have utility in concept development and in developing measures that can also be used in representative samples.     

Cortical regions activated by the subjective sense of perceptual coherence of environmental sounds: A proposal for a neuroscience of intuition

According to the Oxford English Dictionary, intuition is “the ability to understand or know something immediately, without conscious reasoning.” In other words, people continuously, without conscious attention, recognize patterns in the stream of sensations that impinge upon them. The result is a vague perception of coherence, which subsequently biases thought and behavior accordingly. Within the visual domain, research using paradigms with difficult recognition has suggested that the orbitofrontal cortex (OFC) serves as a fast detector and predictor of potential content that utilizes coarse facets of the input. To investigate whether the OFC is crucial in biasing task-specific processing, and hence subserves intuitive judgments in various modalities, we used a difficult-recognition paradigm in the auditory domain. Participants were presented with short sequences of distorted, nonverbal, environmental sounds and had to perform a sound categorization task. Imaging results revealed rostral medial OFC activation for such auditory intuitive coherence judgments. By means of a conjunction analysis between the present results and those from a previous study on visual intuitive coherence judgments, the rostral medial OFC was shown to be activated via both modalities. We conclude that rostral OFC activation during intuitive coherence judgments subserves the detection of potential content on the basis of only coarse facets of the input.     

Interpreting dissociations between regular and irregular past-tense morphology: Evidence from event-related potentials

Neuropsychological dissociations between regular and irregular English past-tense morphology have been reported using a lexical decision task in which past-tense primes immediately precede present-tense targets. We present N400 event-related potential data from healthy participants using the same design. Both regular and irregular past-tense forms primed corresponding present-tense forms, but with a longer duration for irregular verbs. Phonological control conditions suggested that differences in formal overlap between prime and target contribute to, but do not account for, this difference, suggesting a link between irregular morphology and semantics. Further analysis dividing the irregular verbs into two categories (weak irregular and strong) revealed that priming for strong verbs was reliably stronger than that for weak irregular and regular verbs, which were statistically indistinguishable from one another. We argue that, although we observe a regular-irregular dissociation, the nature of this dissociation is more consistent with single- than with dual-system models of inflectional morphology.     

Depression in Women with Heart Disease: The Importance of Social Role Performance and Spirituality

Compared with men, women are more likely to experience depression, and depression increases risk of morbidity and mortality in individuals with heart disease. Psychosocial interventions have been developed for depressed patients with heart disease; however, women's experience of chronic disease differs from men's and women may benefit from interventions tailored to address their difficulties. Spirituality and social roles have been related to depressive symptoms in other populations. To identify the relationship between depression and spirituality and social role performance (i.e., role concerns, role rewards and confidence in ability to fulfill roles) in women with heart disease, we assessed depressive symptoms, spirituality, social role functioning and medical history in 125 women with heart disease. After controlling for age and severity of medical conditions, spirituality, role confidence and role concerns were significantly associated with depressive symptoms. Consideration of spirituality and aspects of social role performance may be important when developing psychosocial interventions for depressed women with heart disease.     

Testing and Training Analogical Responding in Young Children Using A Relational Evaluation Procedure

The Psychological Record - Analogical responding, or relating relations, as operationally defined by relational frame theory (RFT), is ubiquitous in everyday language and cognition, and is a key...