Changes in Pediatric Health-Related Quality of Life in Cystic Fibrosis After IV Antibiotic Treatment for Pulmonary Exacerbations

Intravenous (IV) antibiotic therapy for pulmonary exacerbations (PE) has been shown to improve pulmonary functioning for patients with cystic fibrosis (CF); however, little is known about its effects on pediatric health-related quality of life (HRQOL). This prospective study assessed the impact of IV treatment of a PE on generic and CF-specific HRQOL for children and adolescents with CF. Participants included 52 children and adolescents with CF experiencing a PE (M _age = 13.6 years; 54% males; M_\textFEV1% M_{{{\text{FEV}}_{1\% } }} predicted = 58.8%). HRQOL, pulmonary functioning, and body mass index were assessed before and after IV antibiotic treatment. Results of this prospective, observational study indicated significant improvements on CFQ-R Respiratory (M _{change score} = 11.7; 95% CI = 6.3–17.1; p < .0001) and Weight (M _{change score} = 15.9; 95% CI = 7.9–23.8; p < .0001) scales. The CF-specific measure was more sensitive to changes in HRQOL than the generic instrument. These data suggest that CF-specific HRQOL improves with treatment for a PE with IV antibiotics. The noted statistically and clinically significant changes in the CFQ-respiratory scale indicate that the measure may be beneficial to pulmonary health care teams.     

Empathy towards individuals of the same and different ethnicity when depicted in negative and positive contexts

Individuals can show different empathy responses towards others depending on in-group and out-group biases. The present research tested empathy biases related to ethnicity when targets were depicted in negative and positive contexts. Caucasian (n = 99) and Asian (n = 99) participants gave subjective ratings for images depicting same or other ethnicity individuals in socially-relevant negative and positive contexts. Participants rated significantly higher on all three dimensions of empathy (affect, perspective taking, and understanding) for same ethnicity targets than for other ethnicity targets. However, this bias was found only for targets depicted in negative contexts. Moreover, no ethnicity bias was found for ratings of valence, arousal, distress, and interest. The results suggest that ethnicity-related biases in empathy are present, are limited to negative contexts, and are not merely a manifestation of a more general cognitive or affective bias.     

Rumination and suicidal ideation: The moderating roles of hope and optimism

The current study aimed to investigate whether the correlation between rumination and suicidal ideation is moderated by the presence of hope and optimism. It was hypothesized that both hope and optimism would moderate (weaken) the relationship between rumination and suicidal ideation. Two hundred and ninety-eight participants completed self-report measures of hope, optimism, rumination (brooding and reflection), and depression. Results demonstrated that both hope and optimism weakened the relationship between rumination and suicidal ideation, as well as the relationships between both subscales of rumination and suicidal thinking. These results were found when controlling for symptoms of depression. Results suggest that a ruminative thinking style may be most harmful when an absence of hope or optimism is also present.     

Fighting for independence: Significant others' goals for oneself incite reactance among the powerful

We tested the prediction that power increases people's tendencies to act against the goals their close significant others have for them. Participants in Study 1 all reported in a pre-test that their mother wanted them to achieve, but that they themselves were relatively less interested in achieving. A week later, high-power (but not neutral-power) participants who were reminded of their mother were subsequently less likely to pursue an achievement goal. Study 2 replicated this pattern of results with romantic partners and showed that the effects were strongest when individuals were personally less interested in pursuing a goal they believed their significant other held for them. In Study 3, we looked at mothers and healthy eating goals, and found that the predicted pattern only emerged for close significant others. Further, feelings of reactance mediated high-power participants' tendencies to act against significant-other goals that they themselves held less strongly.     

An analysis of independence and interactions of brain substrates that subserve multiple attributes, memory systems, and underlying processes

It is proposed that memory is organized into event-based, knowledge-based, and rule-based memory systems. Furthermore, each system is composed of the same set of multiple attributes and characterized by a set of process oriented operating characteristics that are mapped onto multiple neural regions and interconnected neural circuits. Based on this theoretical model of memory, it is possible to investigate the independence and interaction among brain regions between any two systems for any of the proposed attributes or processes. This applies also to the investigation of independence and interactions between any two attributes within a system and between processes associated with a system for any of the proposed attributes. In this article, research evidence is presented to suggest that there are both dissociations and interactions between the hippocampus and caudate nucleus in mediating spatial and response attributes within the event-based memory system, between the hippocampus and the parietal cortex in subserving the spatial attribute within the event-based and knowledge-based memory systems, and between the hippocampus and the prefrontal cortex in subserving the spatial attribute within the event-based and rule-based memory systems.     

The mediating role of work locus of control on the relationship among emotional intelligence,organisational citizenship behaviours,and mental health among nurses

Using a cross‐sectional design to evaluate the perceptions of 242 nurses working in a Malaysian hospital, this study investigates the mediating role of work locus of control (WLOC) on the relationship among emotional intelligence (EI), organisational citizenship behaviours (OCBs), and mental health among nurses. Additionally, the role of EI is examined. Findings indicate that EI correlates positively with OCBs and negatively with mental health and that WLOC mediates the relationship between EI and OCBs. However, WLOC does not mediate the relationship between EI and mental health. An in‐depth understanding of nurses' EI provides insights into health institution management to increase organisational outcomes. Results of this study are interpreted to indicate that EI should be part of nurse training and that OCBs are associated with performance and productivity. It is suggested that EI could also be included in selection processes to encourage growth and development of a health institution.     

Exploring emotional and cognitive conflict using speeded voluntary facial expressions

Affective conflict and control may have important parallels to cognitive conflict and control, but these processes have been difficult to quantitatively study with emotionally naturalistic laboratory paradigms. The current study examines a modification of the AX-Continuous Performance Task (AX-CPT), a well-validated probe of cognitive conflict and control, for the study of emotional conflict. In the Emotional AX-CPT, speeded emotional facial expressions measured with electromyography (EMG) were used as the primary response modality, and index of emotional conflict. Bottom-up emotional conflict occurred on trials in which precued facial expressions were incongruent with the valence of an emotionally evocative picture probe (e.g., smiling to a negative picture). A second form of top-down conflict occurred in which the facial expression and picture probe were congruent, but the opposite expression was expected based on the precue. A matched version of the task was also performed (in a separate group of participants) with affectively neutral probe stimuli. Behavioral interference was observed, in terms of response latencies and errors, on all conflict trials. However, bottom-up conflict was stronger in the emotional version of the task compared to the neutral version; top-down conflict was similar across the two versions. The results suggest that voluntary facial expressions may be more sensitive to indexing emotional than nonemotional conflict, and importantly, may provide an ecologically valid method of examining how emotional conflict may manifest in behavior and brain activity.     

Driving forces in free visual search: An ethology

Visual search typically involves sequences of eye movements under the constraints of a specific scene and specific goals. Visual search has been used as an experimental paradigm to study the interplay of scene salience and top-down goals, as well as various aspects of vision, attention, and memory, usually by introducing a secondary task or by controlling and manipulating the search environment. An ethology is a study of an animal in its natural environment, and here we examine the fixation patterns of the human animal searching a series of challenging illustrated scenes that are well-known in popular culture. The search was free of secondary tasks, probes, and other distractions. Our goal was to describe saccadic behavior, including patterns of fixation duration, saccade amplitude, and angular direction. In particular, we employed both new and established techniques for identifying top-down strategies, any influences of bottom-up image salience, and the midlevel attentional effects of saccadic momentum and inhibition of return. The visual search dynamics that we observed and quantified demonstrate that saccades are not independently generated and incorporate distinct influences from strategy, salience, and attention. Sequential dependencies consistent with inhibition of return also emerged from our analyses.     

Speech perception and short-term memory deficits in persistent developmental speech disorder

Children with developmental speech disorders may have additional deficits in speech perception and/or short-term memory. To determine whether these are only transient developmental delays that can accompany the disorder in childhood or persist as part of the speech disorder, adults with a persistent familial speech disorder were tested on speech perception and short-term memory. Nine adults with a persistent familial developmental speech disorder without language impairment were compared with 20 controls on tasks requiring the discrimination of fine acoustic cues for word identification and on measures of verbal and nonverbal short-term memory. Significant group differences were found in the slopes of the discrimination curves for first formant transitions for word identification with stop gaps of 40 and 20 ms with effect sizes of 1.60 and 1.56. Significant group differences also occurred on tests of nonverbal rhythm and tonal memory, and verbal short-term memory with effect sizes of 2.38, 1.56, and 1.73. No group differences occurred in the use of stop gap durations for word identification. Because frequency-based speech perception and short-term verbal and nonverbal memory deficits both persisted into adulthood in the speech-impaired adults, these deficits may be involved in the persistence of speech disorders without language impairment.