Informed Choice in Direct-to-Consumer Genetic Testing (DTCGT) Websites: A Content Analysis of Benefits,Risks, and Limitations

An informed choice about health-related direct-to-consumer genetic testing (DTCGT) requires knowledge of potential benefits, risks, and limitations. To understand the information that potential consumers of DTCGT services are exposed to on company websites, we conducted a content analysis of 23 health-related DTCGT websites. Results revealed that benefit statements outweighed risk and limitation statements 6 to 1. The most frequently described benefits were: 1) disease prevention, 2) consumer education, 3) personalized medical recommendations, and 4) the ability to make health decisions. Thirty-five percent of websites also presented at least one risk of testing. Seventy-eight percent of websites mentioned at least one limitation of testing. Based on this information, potential consumers might get an inaccurate picture of genetic testing which could impact their ability to make an informed decision. Practices that enhance the presentation of balanced information on DTCGT company websites should be encouraged.     

Computational psychiatry

Computational ideas pervade many areas of science and have an integrative explanatory role in neuroscience and cognitive science. However, computational depictions of cognitive function have had surprisingly little impact on the way we assess mental illness because diseases of the mind have not been systematically conceptualized in computational terms. Here, we outline goals and nascent efforts in the new field of computational psychiatry, which seeks to characterize mental dysfunction in terms of aberrant computations over multiple scales. We highlight early efforts in this area that employ reinforcement learning and game theoretic frameworks to elucidate decision-making in health and disease. Looking forwards, we emphasize a need for theory development and large-scale computational phenotyping in human subjects.     

Toward an electrocortical biomarker of cognition for newborn infants

The event-related potential (ERP) effect of mismatch negativity (MMN) was the first electrophysiological probe to evaluate cognitive processing (change detection) in newborn infants. Initial studies of MMN predicted clinical utility for this measure in identification of infants at risk for developmental cognitive deficits. These predictions have not been realized. We hypothesized that in sleeping newborn infants, measures derived from wavelet assessment of power in the MMN paradigm would be more robust markers of the brain's response to stimulus change than the ERP-derived MMN. Consistent with this premise, we found increased power in response to unpredictable and infrequent tones compared to frequent tones. These increases were present at multiple locations on the scalp over a range of latencies and frequencies and occurred even in the absence of an ERP-derived MMN. There were two predominant effects. First, theta band power was elevated at middle and late latencies (200 to 600 ms), suggesting that neocortical theta rhythms that subserve working memory in adults are present at birth. Second, late latency (500 ms) increased power to the unpredictable and infrequent tones was observed in the beta and gamma bands, suggesting that oscillations involved in adult cognition are also present in the neonate. These findings support the expectation that frequency dependent measures, such as wavelet power, will improve the prospects for a clinically useful test of cortical function early in the postnatal period.     

On the time course of exogenous cueing effects in bilinguals: higher proficiency in a second language is associated with more rapid endogenous disengagement

Previous investigations have demonstrated a bilingual advantage on various aspects of executive control. It remains unclear how the language proficiency of bilinguals might relate to the mechanisms involved in attentional disengagement. In the present investigation, we tested the hypothesis that high bilingual proficiency would lead to a more rapid endogenous disengagement of attention from task-irrelevant peripheral cues. We predicted that more rapid attentional disengagement would result in an earlier appearance of inhibition of return (IOR). In this study Hindi-English bilinguals who differed in their L2 (English) proficiency participated in a target detection task. Visual targets were preceded by uninformative peripheral cues at various stimulus onset asynchronies (SOAs) allowing for us to visualize the time course of cue-related facilitation and inhibition. High-proficient Hindi-English bilinguals showed an earlier appearance of IOR than did low-proficient bilinguals, suggesting increased efficiency in disengagement of attention from task-irrelevant inputs. Furthermore, consistent with the "global" advantage that characterizes bilinguals in many tasks, the high-proficient group outperformed low-proficient bilinguals in overall reaction time.     

A Mixed Methods Approach to Vulnerability and Quality of Life Assessment of Waste Picking in Urban Nigeria

Quality of life (QoL) studies have become acceptable globally as indicators of how well a people are living. They are increasingly being used to identify and design areas of intervention to raise the wellbeing of a population. While studies on livelihoods in the informal waste recycling system of developing country cities have also been on the increase in recent years, assessments of the QoL expectations within the livelihoods framework in the informal waste recycling sector seem surprisingly few. Studies of this nature have also not been undertaken in the context of Nigerian socio-political, cultural and economic environment. Applying qual-dominant mixed methods approach to the livelihood activity of waste picking in the commercial city of Aba in southeastern Nigeria, this paper identifies predominant social indicators relevant to the Aba scavengers, waste pickers?? perceptions and QoL expectations, and potential outcomes of meeting the QoL expectations of waste pickers in the area. It also categorizes pickers?? vulnerabilities into four levels of increasing magnitude. Given that African social dynamics do not always or often find expression, fully or partially, in figures, the paper stresses the need to apply ethnographic and qualitative research methods in assessment of QoL and wellbeing in the informal waste recycling system. It further argues that integrating QoL assessments into public decision-making and social policy in Nigeria will contribute significantly towards meeting some of the Millennium Development Goals (MDGs) while also engendering sustainable urban livelihood outcomes.     

Forms of benefit sharing in global health research undertaken in resource poor settings: a qualitative study of stakeholders' views in Kenya

Background  

Increase in global health research undertaken in resource poor settings in the last decade though a positive development has raised ethical concerns relating to potential for exploitation. Some of the suggested strategies to address these concerns include calls for providing universal standards of care, reasonable availability of proven interventions and more recently, promoting the overall social value of research especially in clinical research. Promoting the social value of research has been closely associated with providing fair benefits to various stakeholders involved in research. The debate over what constitutes fair benefits; whether those that addresses micro level issues of justice or those focusing on the key determinants of health at the macro level has continued. This debate has however not benefited from empirical work on what stakeholders consider fair benefits. This study explores practical experiences of stakeholders involved in global health research in Kenya, over what benefits are fair within a developing world context.     

Perceptual and motor inhibition of return: components or flavors?

The most common evidence for inhibition of return (IOR) is the robust finding of increased response times to targets that appear at previously cued locations following a cue?Ctarget interval exceeding ~300?ms. In a variation on this paradigm, Abrams and Dobkin (Journal of Experimental Psychology: Human Perception and Performance 20:467?C477, 1994b) observed that IOR was greater when measured with a saccadic response to a peripheral target than with that to a central arrow, leading to the conclusion that saccadic responses to peripheral targets comprise motoric and perceptual components (the two-components theory for saccadic IOR), whereas saccadic responses to a central target comprise a single motoric component. In contrast, Taylor and Klein (Journal of Experimental Psychology: Human Perception and Performance 26:1639?C1656, 2000) discovered that IOR for saccadic responses was equivalent for central and peripheral targets, suggesting a single motoric effect under these conditions. Rooted in methodological differences between the studies, three possible explanations for this discrepancy can be found in the literature. Here, we demonstrate that the empirical discrepancy is rooted in the following methodological difference: Whereas Abrams and Dobkin (Journal of Experimental Psychology: Human Perception and Performance 20:467?C477, 1994b) administered central arrow and peripheral onset targets in separate blocks, Taylor and Klein (Journal of Experimental Psychology: Human Perception and Performance 26:1639?C1656, 2000) randomly intermixed these stimuli in a single block. Our results demonstrate that (1) blocking central arrow targets fosters a spatial attentional control setting that allows for the long-lasting IOR normally generated by irrelevant peripheral cues to be filtered and (2) repeated sensory stimulation has no direct effect on the magnitude of IOR measured by saccadic responses to targets presented about 1?s after a peripheral cue.     

Resting EEG in alpha and beta bands predicts individual differences in attentional blink magnitude

Accuracy for a second target (T2) is reduced when it is presented within 500 ms of a first target (T1) in a rapid serial visual presentation (RSVP) - an attentional blink (AB). There are reliable individual differences in the magnitude of the AB. Recent evidence has shown that the attentional approach that an individual typically adopts during a task or in anticipation of a task, as indicated by various measures, predicts individual differences in the AB deficit. It has yet to be observed whether indices of attentional approach when not engaged in a goal-directed task are also relevant to individual differences in the AB. The current studies investigated individual differences in the AB by examining their relationship with attention at rest using quantitative measures of EEG. Greater levels of alpha at rest were associated with larger AB magnitudes, where greater levels of beta at rest were associated with smaller AB magnitudes. Furthermore, individuals with more beta than alpha demonstrated a smaller AB effect than individuals with more alpha than beta. Our results suggest that greater attentional engagement at rest, when not engaged in a goal-directed task, is associated with smaller AB magnitudes.     

The impact of rater agreeableness and rating context on the evaluation of poor performance

We tested the effects of rater agreeableness on the rating of others’ poor performance in performance appraisal (PA). We also examined the interactions between rater agreeableness and two aspects of the rating context: ratee self‐ratings and the prospect of future collaboration with the ratee. Participants (n= 230) were allocated to one of six experimental groups (a 3 × 2 between‐groups design) or a control group (n= 20). Participants received accurate, low‐deviated, or high‐deviated self‐ratings from the ratee. Half were notified they would collaborate with the ratee in a future task. High rater agreeableness, positive deviations in self‐rating, and the prospect of future collaboration were all independent predictors of higher PA ratings. The interactions between rater agreeableness and rating context were very small. We argue that conflict avoidance is an important motivation in the PA process.     

A Qualitative Exploration of Sleep Habits and Intervention Needs Among Youth with Cystic Fibrosis

Evidence suggests that individuals with Cystic Fibrosis (CF) experience difficulties with sleep architecture and hygiene, although research is limited. There are currently no behavioral sleep interventions for youth with CF. The current study used qualitative methods to understand sleep needs and concerns among youth with CF, as well as to obtain feedback about potentially useful behavioral sleep intervention strategies. Semi-structured interviews were conducted with youth with CF between the ages of 11–17 and their parents. Themes were extracted from the data and will be used to inform the development of a brief behavioral sleep intervention for youth with CF. Youth and their parents described several CF-specific sleep concerns, often related to respiratory symptoms, and a number of strategies used to manage these concerns. They also described concerns that apply to the general population, including pervasive use of technology around bedtime. Many evidence-based behavioral sleep intervention strategies are acceptable to youth with CF, although modifications are appropriate to reduce time burden and address CF-specific needs. Youth with CF experience a number of disease-specific and more generalized sleep concerns which are likely amenable to behavioral intervention. Results from this study will be used to inform the development of a brief behavioral sleep intervention for youth with CF.