环境基因组计划(EGP)对预防医学发展的影响

1998年美国正式启动环境基因组计划,该计划旨在探讨环境－基因的交互作用,寻找对环境因素损伤的易感基因及环境反应基因的多态性在疾病病因和发病过程中的作用,因而该计划的实施将对预防医学的发展产生重要的影响。     

A follow-up of a media-based,worksite smoking cessation program

Described an examination of data collected 2 years following the onset of a media-based, worksite smoking cessation intervention. Thirty-eight companies in Chicago were randomly assigned to one of two experimental conditions. In the inital 3-week phase, all participants in both conditions received self-help manuals and were instructed to watch a 20-day televised series designed to accompany the manual. In addition, participants in the group (G) condition received six sessions emphasizing quitting techniques and social support. In the second phase, which continued for 12 months, employees in G participated in monthly peer-led support groups and received incentives, while participants in the nongroup (NG) condition received no further treatment. Twenty-four months after pretest, 30% of employees in G were abstinent compared to only 19.5% in NG. This study is one of the few experimentally controlled worksite smoking cessation interventions to demonstrate significant program differences 2 years following the initial intervention. Our thanks to Lori Klett and Libby Yeager-Turner for their help in data collection. Work on the project was supported in part by National Institute on Drug Abuse grant DA-04406-01 and a grant from the Chicago Lung Association to the second author.     

Effects of active student response during error correction on the acquisition, maintenance, and generalization of science vocabulary by elementary students: A systematic replication

We compared active student response (ASR) error correction and no-response (NR) error correction while teaching science terms to 5 elementary students. When a student erred on ASR terms, the teacher modeled the definition and the student repeated it. When a student erred on NR terms, the teacher modeled the definition while the student looked at the vocabulary card. ASR error correction was superior on each of the study's seven dependent variables.     

Family timing in late adolescence and early adulthood: The case of southern males

Social science research and theory about familial orientations and reproductive ideals have largely neglected males' attitudes. Drawing on demographic and status attainment perspectives, this study applies a model of processes underlying marriage and family timing to longitudinal data on 288 young adult males from the Southern Youth Study. Several posited influences of family of origin factors, significant others, and adolescent status and familial aspirations on marital timing and early family growth are assessed.Development of this report was sponsored in part by the Texas Agricultural Experiment Station and contributes both to TAES Project H-2811 and to USDA (CSRS) Regional Research Project S-81, and in part by the Maxwell Policy Center on Aging and the All-University Gerontology Center, Syracuse University through Title IV-C Grant #90-A-1054101 from the Administration on Aging, Department of Health, Education, and Welfare. Information for analysis was obtained by pooling data collected under grants provided by the Agricultural Experiment Stations of Alabama, Georgia, South Carolina, and Texas. Appreciation is expressed to John Womack, Paul D. Mader, and G. David Curry for their advice at various stages of this research.     

Status and familial orientations of rural Mexican-American youth: Integration and conflict within aspirational frames of reference

Studies regarding status aspirations among Mexican-American youth have presumed that life goals are integrated and congruent. In the present paper, after reviewing cultural and structural explanations of low Mexican-American attainment, an alternative line of inquiry is suggested which questions these assumptions and specifies types of conflicts that may arise among occupational, educational, and familial orientations. Using data from a survey of South Texas high school students, the prevalence of such conflicts are observed by sex, and implications for future attainment patterns are discussed.     

The inclination of modern jurists to associate lawyers with doctors: Plato's response inGorgias 464–465

From the turn of the century, jurists have tended to associate lawyers with doctors as professionals and tried to ground this association in an analogy between law and medicine. Paradoxically, such comparisons suggest that American law and medicine are not analogous, while an analogy proposed by Plato illumines more fundamental respects in which law and medicine might be truly analogous.     

A Systematic Review of the Relationship Between Rumination and Suicidality

Rumination has been persistently implicated in the etiology of hopelessness and depression, which are proximal predictors of suicidality. As a result, researchers have started to examine the role of rumination in suicidality. This systematic review provides a concise synopsis of the current progress in examining the relationship between rumination and suicidality, and highlights areas for future research. A search of the international literature was conducted using the three main psychological and medical databases. Eleven studies were identified providing evidence, with one exception, of a relationship between rumination and suicidality. This review also highlights the considerable dearth of studies on this area of concern, specifically of case‐control and prospective, clinical studies, in the worldwide literature.     

尼可地尔与前列地尔预处理对大鼠心肌缺血再灌注的影响

研究尼可地尔、前列地尔及两药物联合应用预处理对心肌缺血再灌注中的影响,探究其作用机制.采用Tunel法检测心肌组织的凋亡情况,免疫组化法检测Bax、Bcl-2和caspase-3的蛋白表达情况.结果显示尼可地尔和前列地尔半剂量联合组细胞凋亡数、Bax和caspase-3的表达量均明显低于其他给药组(P＜0.05),Bcl-2的表达量明显高于其他给药组(P＜0.05);尼可地尔和前列地尔单给药组细胞凋亡、Bax、caspase-3表达均有降低,Bcl-2表达升高,但效果不及联合用药半剂量组.以此得出结论尼可地尔和前列地尔的联合用药效果较好,可加强对心肌的保护作用.