Intraadministration associations: conditional hyperalgesia elicited by morphine onset cues

There is evidence that exteroceptive cues associated with drug administration elicit conditional compensatory responding (e.g., hyperalgesia in organisms with a history of morphine administration). Recently it has become apparent that, within each administration, interoceptive early-drug onset cues (DOCs) may become associated with the later, larger drug effect (intraadministration associations). The present experiments evaluated DOC-elicited conditional hyperalgesia in rats intravenously infused with morphine. The results indicated that DOC-elicited hyperalgesia contributes to tolerance to the analgesic effect of morphine, and such DOC-elicited hyperalgesia is an associative phenomenon, rather than a sensitized response to the opiate. The findings suggest that associative analyses of tolerance should acknowledge the conditional responding elicited by DOCs, and extinction-based addiction treatments should incorporate extinction of DOC-elicited conditional responding.     

Regularities of source recognition: ROC analysis

Source memory has become the focus of a growing number of investigations in a variety of fields. An appropriate model for source memory is, therefore, of increasing importance. A simple 2-dimensional signal-detection model of source recognition is presented. The receiver operating characteristics (ROCs) obtained from 3 experiments are then used to test the model. The data demonstrate 3 regularities: convex ROCs, z-ROCs with linear slopes of 1.00, and slightly concave z-ROCs. Two of these regularities support the model. The 3rd requires a revision of the model. This revised model is fitted to the data. The implications of these regularities for other theories are also discussed.     

Differential functioning of the Beck depression inventory in late-life patients: use of item response theory

The present analyses examined age-related measurement bias in responses to items on the revised Beck Depression Inventory (BDI) in depressed late-life patients versus midlife patients. Item response theory (IRT) models were used to equate the scale and to differentiate true-group differences from bias in measurement in the 2 samples. Baseline BDI data (218 late life and 613 midlife) were used for the present analysis. IRT results indicated that late-life patients tended to report fewer cognitive symptoms, especially at low to average levels of depression. Conversely, they tended to report more somatic symptoms, especially at higher levels of depression. Adjusted cutoff scores in the late-life group are provided, and possible reasons for age-related differences in the performance of the BDI are discussed.     

Fabry disease in genetic counseling practice: recommendations of the National Society of Genetic Counselors

The objective of this document is to provide health care professionals with recommendations for genetic counseling and testing of individuals with a suspected or confirmed diagnosis of Fabry disease, with a family history of Fabry disease, and those identified as female carriers of Fabry disease. These recommendations are the opinions of a multicenter working group of genetic counselors, medical geneticists, and other health professionals with expertise in Fabry disease counseling, as well as an individual with Fabry disease who is a founder of a Fabry disease patient advocacy group in the United States. The recommendations are U.S. Preventive Task Force Class III, and they are based on clinical experience, a review of pertinent English-language articles, and reports of expert committees. This document reviews the genetics of Fabry disease, the indications for genetic testing and interpretation of results, psychosocial considerations, and references for professional and patient resources. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a healthcare provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.     

Helen Flanders Dunbar,John Dewey,and clinical pragmatism: reflections on method in psychosomatic medicine and bioethics

This article outlines the method utilized by physicians and major figures in the founding of Clinical Pastoral Education, Helen Flanders Dunbar, in her work of 1943, Psychosomatic Diagnosis, and relates it to the currently evolving approach in bioethics known as clinical pragmatism. It assesses Dewey's influence on both Dunbar in psychosomatic medicine and clinical pragmatism in bioethics, and illustrates the breadth of influence of the school of philosophical thought known as pragmatism with which Dewey's name and those of William James and Charles Sanders Pierce are most often identified.     

Minimizing error in measurement of error: a proposed method for calculation of error in a two-dimensional motor task

Traditional one-dimensional error scores are still consistently used in research on motor learning to quantify two-dimensional error; however, the inherent differences in two-dimensional tasks render that application inappropriate and often misleading. Consequently, the purpose of this paper was to propose a novel method of presenting errors, which more precisely represents the accuracy, direction, and variability of error in two-dimensional settings. Although closely related to several alternatives for representing errors, the methodology used and the results obtained provide a more accurate procedure for pinpointing critical trends in what have been commonly referred to as AE (absolute error), VE (variable error), CE (constant error), and E (total variability). The proposed measurements of AVE (adjusted variable error), DE (directional error), TSE (total spread of error), and RE (radial error) provide composite error scores carrying a variety of information about performance on two-dimensional tasks. Formulas and examples are provided to facilitate computation and enhance understanding of the proposed scores.     

Psychometric Study of the Child and Adolescent Functional Assessment Scale: Prediction of Contact with the Law and Poor School Attendance

The predictive validity of the Child and Adolescent Functional Assessment Scale (CAFAS) is investigated using the data set generated by the national evaluation of the demonstration service grants funded by the Center for Mental Health Services. Logistic regressions were performed separately for contact with the law and poor school attendance, which were both assessed at 6 months postintake. Other variables included in the model besides the CAFAS total score at intake were age, gender, and family risk factors. The results show that the CAFAS total score at intake was a positive predictor of the likelihood of contact with the law and poor school attendance, even after controlling for age, gender, and risk factors. Furthermore, the CAFAS total score was predictive even after excluding scores on CAFAS subscales, which may have been influenced by absenteeism or delinquency. These findings are consistent with recent research indicating that the CAFAS predicts recidivism in juvenile delinquents.This research was conducted while the author was a Research Associate at the Population Studies Center, University of Michigan, Ann Arbor, MI     

Punishments adolescents find justified: an examination of altitudes toward delinquency

The purpose of this study was to examine adolescents' attitudes toward delinquency, specifically the degree to which they find norm violations acceptable in various circumstances. A total of 1,914 Dutch youths participated: 1,046 reported having committed no crimes in the past year, 578 reported having committed only nonviolent offenses, and 290 reported having committed both violent and nonviolent offenses. It was hypothesized that, in general, delinquents would prescribe less severe punishments for deviant behavior, irrespective of the circumstances. This hypothesis was rejected. It was found, however, that violent delinquents were significantly more tolerant of violent behavior as compared with nondelinquents, with one important exception: when injury was inflicted on someone they knew, they were as little inclined to excuse the perpetrator as were nondelinquents. Violent delinquents discriminated most strongly between friends and strangers as both victims and perpetrators.     

The Temple-Wisconsin Cognitive Vulnerability to Depression Project: lifetime history of axis I psychopathology in individuals at high and low cognitive risk for depression

The authors tested the cognitive vulnerability hypotheses of depression with a retrospective behavioral high-risk design. Individuals without current Axis I diagnoses who exhibited either negative or positive cognitive styles were compared on lifetime prevalence of depressive and other disorders and the clinical parameters of depressive episodes. Consistent with predictions, cognitively high-risk participants had higher lifetime prevalence than low-risk participants of major and hopelessness depression and marginally higher prevalence of minor depression. These group differences were specific to depressive disorders. The high-risk group also had more severe depressions than the low-risk group, but not longer duration or earlier onset depressions. The risk group differences in prevalence of depressive disorders were not mediated by current depressive symptoms.     

Perceiving circular heading in noncanonical flow fields

Five experiments examined circular heading perception with optical flows that departed from the canonical form. Noncanonicity was achieved through nonrigidity of the environment (Experiments 1 and 2), oscillations of the point of observation (Experiment 3), and the bending of light (Experiments 4 and 5). In Experiments 1 and 2, perception was impaired more by nonrigidity of the ground plane than by nonrigidity of the medium. In Experiment 3, perception was unimpaired by noncanonical flows induced by the bounce and sway of observer locomotion. In Experiments 4 and 5, perception was not impaired when light paths were distorted by a spherical projection, but perception was impaired when they were distorted by a sine function. Results are discussed in relation to the hypothesis that the information for perceiving heading is the ordinal pattern of optical flow.