Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats

In a series of experiments, the consequences of a single and double social conflict on various behaviours and body weight in rats were studied. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for one hour, either once, or twice at the same time on two consecutive days. To assess the consequences of social defeat, three experiments were performed with independent groups of rats. In the first experiment, an open field test was performed two days after the last conflict. Locomotor activity was strongly reduced after social defeat. There were no differences between the single and double defeat group. To assess the effects of social defeat on subsequent social behaviour, a second experiment was performed in which experimental animals were confronted with an unfamiliar non-aggressive rat two days after a single or double conflict. Social defeat resulted in a reduction of social contact with the unfamiliar conspecific. There was no difference between the single and double conflict group. In the third experiment, the effects of social conflict on food intake, body weight and saccharine preference were measured. Food intake was not affected after a single conflict, but in the double conflict group food intake was decreased for several days. Body weight gain was decreased after both single and double social defeat. The decrease was stronger in the double conflict group. Water intake and saccharine preference were not significantly affected. This study revealed that social defeat in rats causes pronounced changes in various behaviours and body weight. Different aspects of behaviour are differentially affected by defeat with respect to the magnitude and time course of the changes induced. Moreover, different behavioural parameters are differentially sensitive to repetition of the stressor.     

DNA-sequence patenting: National Society of Genetic Counselors (NSGC) position paper

In November 2000, the Genetic Services Committee of the National Society of Genetic Counselors (NSGC) convened a working group to draft a position paper on patenting of DNA-sequences. The mandate of the group was to produce general position statements that support the perspective and needs of consumers of DNA-based genetic tests and therapies (our patients and their families) and participants in DNA-based genetic research. After review and discussion of the literature on DNA-sequence patenting issues, the working group drafted position statement points that support current United States Patent and Trademark Office (USPTO) guidelines; broad licensing of DNA-sequence patents; nonenforcement of DNA-sequence patents in noncommercial research; reasonable royalty rates; an informed consent process for research participants that discloses whether they can share in any financial rewards relating to the project; the development of guidelines for licensing of DNA-sequence patents; and the establishment of oversight organizations to monitor licensing of DNA-sequence patents. These position statements were approved by the NSGC Board of Directors in the fall of 2001.     

Phases of Group Development: A View from Self Psychology

This paper delineates four phases of group development from the standpoint of self psychological theory. The author contends that a stable sense of groupself develops over time and that the groupself has a distinct number of phases, each of which has a therapeutic impact on members. The individual patient's selfobject experiences include a relationship to the group-as-a-whole, a transference state of which the leader is but one part. Thus, rather than dilute the transference, group analysis offers a unique opportunity to help the individual experience him or herself within a selfobject matrix that extends beyond the dyad. Group analysis leads to a strengthening of the self, especially as it enables the self to experience itself as part of a group identity, which provides alter-ego selfobject experiences, as well as a sense of acceptance within a larger community. This paper attempts to clarify how different selfobject experiences may be highlighted within the groupself at different stages of group development.     

Validation,Persuasion and Recycling: Capitalizing on the Social Ecology of Newspaper Use

Two experiments used clinical validation to increase scrutiny of messages posted in public settings. The first experiment used a 2 (validation: no/yes) × 2 (persuasion: none/"it is important") factorial design to develop messages about newspaper recycling. The prompt (no validation/no persuasion) had little impact on newspaper recycling, but the other 3 signs all resulted in increased recycling while the signs were in place. After signs were removed, recycling remained significantly higher than baseline (marginally significant for validation/persuasion). At the end of the study, number of cognitions favoring recycling was significantly higher in the validation-only condition and was lower in the validation/persuasion condition. Experiment 2 tested whether signs would have more impact if they were sensitive to the social ecology of newspaper recycling; that is, readers' tendency to leave newspapers behind so others may read them. Messages based on a 2 (message: validation-only/validation plus persuasion) × 2 (ecology: no social ecology/social ecology) factorial design supported social ecology's importance. Furthermore, because of the increased sharing in the social ecology conditions, total numbers of newspapers used was significantly lower in those buildings. Validation only yielded sustained behavior change in both Experiments 1 and 2, supporting additional research on the question of whether validation can, by itself, lead to cognitive elaboration and self-persuasion.