发展地看待知识内隐性的判别方法：内隐与外显学习区分的新途径

知识内隐性的判别一直是内隐学习研究领域的研究重点之一,恰当的区分内隐被试和外显被试对于该类研究有着至关重要的意义。本文介绍知识内隐性判别问题的研究历史,由最初的主观标准和客观标准到后来改进的研究方法,指出了随着对待内隐和外显学习两者关系的理论的发展,研究方法有必要与时俱进,并提出了新的区分内隐被试和外显被试的新方法。相对于传统研究方法,新方法从内隐知识和外显知识互为补充、＂任何一种学习即存在内隐学习,也存在外显学习＂的理论指导下,通过被试的猜测水平来判断其内隐水平,并确定＂纯的＂内隐被试的标准。该方法发展地看待内隐学习及其与外显学习的关系,有助于研究者更加深入、精确地研究内隐学习的相关问题。     

Expression of VGLUTs contributes to degeneration and acquisition of learning and memory

Vesicular glutamate transporters (VGLUTs), which include VGLUT1, VGLUT2 and VGLUT3, are responsible for the uploading of L-glutamate into synaptic vesicles. The expression pattern of VGLUTs determines the level of synaptic vesicle filling (i.e., glutamate quantal size) and directly influences glutamate receptors and glutamatergic synaptic transmission; thus, VGLUTs may play a key role in learning and memory in the central nervous system. To determine whether VGLUTs contribute to the degeneration or acquisition of learning and memory, we used an animal model for the age-related impairment of learning and memory, senescence-accelerated mouse/prone 8 (SAMP8). KM mice were divided into groups based on their learning and memory performance in a shuttle-box test. The expression of VGLUTs and synaptophysin (Syp) mRNA and protein in the cerebral cortex and hippocampus were investigated with real-time fluorescence quantitative PCR and western blot, respectively. Our results demonstrate that, in the cerebral cortex, protein expression of VGLUT1, VGLUT2, VGLUT3 and Syp was decreased in SAMP8 with age and increased in KM mice, which displayed an enhanced capacity for learning and memory. The protein expression of VGLUT2 and Syp was decreased in the hippocampus of SAMP8 with aging. The expression level of VGLUT1 and VGLUT2 proteins were highest in KM mouse group with a 76-100% avoidance score in the shuttle-box test. These data demonstrate that protein expression of VGLUT1, VGLUT2 and Syp decreases age-dependently in SAMP8 and increases in a learning- and memory-dependent manner in KM mice. Correlation analysis indicated the protein expression of VGLUT1, VGLUT2 and Syp has a positive correlation with the capacity of learning and memory.     

对"中国基因歧视第一案败诉"的疑问与思考

国人对基因歧视有明显的认识不足.通过五个疑问来深入剖析"中国基因歧视第一案",并对其败诉的结果提出质疑.同时从基因信息的保护、基因改良的伦理问题、对"基因决定论"的辩证思考三方面展开基因伦理的哲学思考,以期提高国人对基因的正确认识并减少基因歧视的发生.     

Does Freedom of Speech Include Hate Speech?

I take it that liberal justice recognises special protections against the restriction of speech and expression; this is what I call the Free Speech Principle. I ask if this Principle includes speech acts which might broadly be termed ‘hate speech’, where ‘includes’ is sensitive to the distinction between coverage and protection, and between speech that is regulable and speech that should be regulated. I suggest that ‘hate speech’ is too broad a designation to be usefully analysed as a single category, since it includes many different kinds of speech acts, each of which involves very different kinds of free speech interests, and may cause very different kinds of harm. I therefore propose to disaggregate hate speech into various categories which are analysed in turn. I distinguish four main categories of hate speech, namely (1) targeted vilification, (2) diffuse vilification, (3) organised political advocacy for exclusionary and/or eliminationist policies, and (4) other assertions of fact or value which constitute an adverse judgment on an identifiable racial or religious group. Reviewing these categories in the light of the justifications for the Free Speech Principle, I will argue that category (1) is uncovered by the Principle, categories (2) and (3) are covered but unprotected, and that category (4) is protected speech.     

从"本体——工夫"维度看中国传统道德理念的内在结构

中国传统道德文化复杂多样,经过两千多年的历史发展和演进,形成了名目繁多、内涵丰富的诸多道德规范或德目。本文从中国传统哲学的本体-工夫思维模式,对中国传统道德理念进行重新排序和定位,提出了二维四面三层次的内在结构模式。中国传统道德文化是一个整体性的存在,具有普遍性与超越性的内在深层结构,正是这一整体性的存在和具有某种普遍性和超越性的内在深层结构,为其现代践行提供了可能性和有效性的理论依据。     

美国积极心理学介评

积极心理学是近年来美国出现的一个新兴的心理学研究领域,它对二战后心理学中存在以病理学研究为重点的倾向提出了异议,主张心理学应对人类自身拥有的正向品质加以研究。文章从其思想主张出发,结合有关研究现状及存在问题对积极心理学进行了一个概括的介绍及简评。     

日本人格心理学研究动向及启示

日本人格心理学领域近几年的研究表明,对“大五”和“自我”的研究是其主要关注点,同时还重视对人际关系的研究,强调理论研究的应用化取向与研究方法的多元化和整合。但目前日本人格心理学研究仍然存在一定局限,对此加深认识,具有重要的借鉴意义。     

预期错误在复合恐惧记忆提取消退中的作用

基于记忆再巩固理论的提取消退范式被证明是一种有效和颇有前景的消除不良记忆的方法。本研究将预期错误(Prediction Error, PE)应用于提取消退范式中, 采用多感官复合刺激模型(声音 + 图片)作为条件刺激, 以皮电反应作为恐惧反应指标, 考察在提取阶段不同的预期错误设置(无PE、单个负性PE、单个正性PE和多重PE)对条件性恐惧记忆提取消退效果有何差异。结果表明：无PE组和多重PE组出现了恐惧的自发恢复和重建效应, 而负性PE组和正性PE组均没有出现恐惧的自发恢复和重建效应。说明了在对复合恐惧记忆进行提取消退时, 提取阶段适当的PE才能使记忆进入再巩固过程, 随后传统消退达到抑制恐惧返回效果, 提取阶段没有PE或PE量过多都不能达到恐惧消退效果。     

法律的道德审视:当代中国卫生法伦理学研究的使命

卫生法伦理学是由医学、法学和伦理学三大学科相互交融、渗透而结合的产物。卫生法伦理学作为一门独立的学科有着独特的研究对象。法律的道德审视,不仅是法伦理学研究的基础途径,更是当代中国卫生法伦理学研究的使命。