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971.
Cognitive conflict plays an important role in tuning cognitive control to the situation at hand. On the basis of earlier findings demonstrating emotional modulations of conflict processing, we predicted that affective states may adaptively regulate goal-directed behavior that is driven by conflict. We tested this hypothesis by measuring conflict-driven control adaptations following experimental induction of four different mood states that could be differentiated along the dimensions of arousal and pleasure. After mood states were induced, 91 subjects performed a flanker task, which provided a measure of conflict adaptation. As predicted, pleasure level affected conflict adaptation: Less pleasure was associated with more conflict-driven control. Arousal level did not influence conflict adaptation. This study suggests that affect adaptively regulates cognitive control. Implications for future research and psychopathology are discussed. 相似文献
972.
We investigated the role of vision in tactile enumeration within and outside the subitizing range. Congenitally blind and
sighted (blindfolded) participants were asked to enumerate quickly and accurately the number of fingers stimulated. Both groups
of participants enumerated one to three fingers quickly and accurately but were much slower and less accurate with four to
nine fingers. Within the subitizing range, blind participants performed no differently from both sighted (blindfolded) and
sighted-seeing participants. Outside of the subitizing range, blind and sighted-seeing participants showed better performance
than did sighted-blindfolded participants, suggesting that lack of access to the predominant sensory modality does affect
performance. Together, these findings further support the claim that subitizing is a general perceptual mechanism and demonstrate
that vision is not necessary for the development of the subitizing mechanism. 相似文献
973.
Duane T. Wegener Richard E. Petty Kevin L. Blankenship Brian Detweiler‐Bedell 《Journal of Consumer Psychology》2010,20(1):5-16
Researchers across many domains have examined the impact of externally presented numerical anchors on perceiver judgments. In the traditional paradigm, “anchored” judgments are typically explained as a result of elaborate thinking (i.e., confirmatory hypothesis testing that selectively activates anchor-consistent information in memory). Consistent with a long tradition in attitude change, we suggest that the same judgments can result from relatively thoughtful or non-thoughtful processes, with more thoughtful processes resulting in judgments that have more lasting impact. We review recent anchoring research consistent with this elaboration-based perspective and discuss implications for past anchoring results and theory in judgment and decision making. 相似文献
974.
N.M.W.J. de Bruin J. Prickaerts J.H.M. Lange S. Akkerman E. Andriambeloson M. de Haan J. Wijnen M. van Drimmelen E. Hissink L. Heijink C.G. Kruse 《Neurobiology of learning and memory》2010,93(4):522-531
Cannabinoid CB1 receptor (CB1R) signaling has been suggested to play an important role in the regulation of memory and cognition. In the present study, our aim was to investigate whether the CB1R antagonist SLV330 (doses ranging from 0.3 to 10 mg/kg, given orally, p.o.) could ameliorate impairments in distinct aspects of cognition using different disruption models in both mice and rats. Effects of SLV330 were tested on working memory deficits in the T-maze Continuous Alternation Task (T-CAT) in mice; episodic memory deficits in the Object Recognition Task (ORT) and Social Recognition Task (SRT) in rats. The acetylcholinesterase inhibitor (AChEI) donepezil (Aricept®, approved for symptomatic treatment of Alzheimer’s disease) and nicotine were used as reference compounds.SLV330 markedly improved aging and scopolamine-induced memory deficits in the T-CAT in mice with a lowest effective dose (LED) of 1 mg/kg p.o., while reversing the cognitive dysfunction induced by the N-methyl-d-aspartate (NMDA) antagonist dizocilpine (MK-801) only at the middle dose of 3 mg/kg. In the ORT, we have found that combined administration of subthreshold doses of SLV330 (1 mg/kg, p.o.) and the AChEI donepezil (0.1 mg/kg, p.o.), that had no discernable effects on performance when given alone, enhanced memory performance in Wistar rats with deficits induced by the muscarinic antagonist scopolamine, suggestive of additive synergistic effects of SLV330 and donepezil on cognitive impairment. Finally, SLV330 was found to have cognition enhancing properties in a time delay paradigm in the SRT at a LED dose of 3 mg/kg (p.o.).In conclusion, the CB1R antagonist SLV330 was found to clearly improve memory in several preclinical models for cognitive impairment. 相似文献
975.
Kevin L. Brown Alexis Agelan Diana S. Woodruff-Pak 《Neurobiology of learning and memory》2010,93(3):303-311
Young adult Purkinje cell degeneration (pcd) mutant mice, with complete loss of cerebellar cortical Purkinje cells, are impaired in delay eyeblink classical conditioning. In the delay paradigm, the conditioned stimulus (CS) overlaps and coterminates with the unconditioned stimulus (US), and the cerebellar cortex supports normal acquisition. The ability of pcd mutant mice to acquire trace eyeblink conditioning in which the CS and US do not overlap has not been explored. Recent evidence suggests that cerebellar cortex may not be necessary for trace eyeblink classical conditioning. Using a 500 ms trace paradigm for which forebrain structures are essential in mice, we assessed the performance of homozygous male pcd mutant mice and their littermates in acquisition and extinction. In contrast to results with delay conditioning, acquisition of trace conditioning was unimpaired in pcd mutant mice. Extinction to the CS alone did not differ between pcd and littermate control mice, and timing of the conditioned response was not altered by the absence of Purkinje cells during acquisition or extinction. The ability of pcd mutant mice to acquire and extinguish trace eyeblink conditioning at levels comparable to controls suggests that the cerebellar cortex is not a critical component of the neural circuitry underlying trace conditioning. Results indicate that the essential neural circuitry for trace eyeblink conditioning involves connectivity that bypasses cerebellar cortex. 相似文献
976.
Kees-Jan Kan Annemie Ploeger Maartje E. J. Raijmakers Conor V. Dolan Han L. J. van der Maas 《Developmental science》2010,13(1):11-27
We present a review of empirical evidence that suggests that a substantial portion of phenotypic variance is due to nonlinear (epigenetic) processes during ontogenesis. The role of such processes as a source of phenotypic variance in human behaviour genetic studies is not fully appreciated. In addition to our review, we present simulation studies of nonlinear epigenetic variance using a computational model of neuronal network development. In each simulation study, time series for monozygotic and dizygotic twins were generated and analysed using conventional behaviour genetic modelling. In the results of these analyses, the nonlinear epigenetic variance was subsumed under the non-shared environmental component. As is commonly found in behaviour genetic studies, observed heritabilities and unique environmentabilities increased with time, whereas common environmentabilities decreased. The fact that the phenotypic effects of nonlinear epigenetic processes appear as unsystematic variance in conventional twin analyses complicates the identification and quantification of the ultimate genetic and environmental causes of individual differences. We believe that nonlinear dynamical system theories provide a challenging perspective on the development of individual differences, which may enrich behaviour genetic studies. 相似文献
977.
978.
The present research explored when observing gaze shifts of another person, involving both the observer and a specific object, enhances desirability of the gazed-at object. Specifically, we offer an initial attempt to test the idea that a three-step sequence consisting of direct gaze at the observer, followed by object-directed gaze and then by direct gaze at the observer, cues the desirability of an object to the observer and hence increases the perceived desirability of the gazed-at object. We examined this hypothesis in three experiments by manipulating eye-gaze shifts and including a no-gaze control condition. In line with our prediction, results showed that the dynamic sequence of gaze shifts indeed increases perceived object desirability. These findings provide new evidence that a sequence of gaze behavior involving the observer and an object plays an important role in influencing affective evaluation of objects. 相似文献
979.
There is considerable evidence indicating that people are primed to monitor social signals of disapproval. Thus far, studies on selective attention have concentrated predominantly on the spatial domain, whereas the temporal consequences of identifying socially threatening information have received only scant attention. Therefore, this study focused on temporal attention costs and examined how the presentation of emotional expressions affects subsequent identification of task-relevant information. High (n = 30) and low (n = 31) socially anxious women were exposed to a dual-target rapid serial visual presentation (RSVP) paradigm. Emotional faces (neutral, happy, angry) were presented as the first target (T1) and neutral letter stimuli (p, q, d, b) as the second target (T2). Irrespective of social anxiety, the attentional blink was relatively large when angry faces were presented as T1. This apparent prioritized processing of angry faces is consistent with evolutionary models, stressing the importance of being especially attentive to potential signals of social threat. 相似文献
980.
Sunscreens with Titanium Dioxide (TiO<Subscript>2</Subscript>) Nano-Particles: A Societal Experiment
The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding
their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal
experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of
sunscreens containing nano-sized titanium dioxide (TiO2) particles. We argue that the marketing of this TiO2 nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for
societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation).
To remedy the current way nano-sized TiO2 containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing
review, designing for safety, and regulative improvements) so that its marketing can become more acceptable. 相似文献