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771.
Glucose and physostigmine effects on morphine- and amphetamine-induced increases in locomotor activity in mice 总被引:2,自引:0,他引:2
Recent findings indicate that glucose antagonizes several behavioral effects of cholinergic antagonists and augments those of cholinergic agonists. For example, scopolamine elicits increased locomotor activity, an action which is attenuated by glucose and by combined treatment with glucose and physostigmine at doses which are individually without effect. Opiate and catecholamine agonists, such as morphine and amphetamine, also elicit hyperactivity. The present study examined interactions of glucose and physostigmine with morphine- and amphetamine-induced hyperactivity. Mice received saline, morphine (10 mg/kg), or amphetamine (1 mg/kg) 50 min prior to testing, followed by saline, physostigmine (0.01, 0.05, 0.1, or 0.2 mg/kg), or glucose (10, 50, 100, or 500 mg/kg) administered 20 min prior to activity testing in an open field. Physostigmine significantly attenuated both morphine- and amphetamine-induced increases in activity, but higher doses were required to attenuate the effects of amphetamine. Like physostigmine, glucose significantly attenuated morphine-induced activity levels, but unlike physostigmine, glucose did not attenuate amphetamine-induced activity. Thus, the behavioral effects of morphine were more susceptible to modification by physostigmine and glucose than were the effects of amphetamine. The attenuation of morphine-induced hyperactivity demonstrates a similarity between glucose and cholinergic agonists, and also indicates that glucose may inhibit, directly or indirectly, opiate functions. More generally, these findings add to the evidence that circulating glucose levels selectively influence a growing list of behavioral and neurobiological functions. 相似文献
772.
This report reviews the literature on the values of alcoholics and addicts in treatment and presents data that suggest a shift in values is involved in recovery from alcoholism through participation in Alcoholics Anonymous and that values clarification and value therapy may be useful in chemical dependency treatment. 相似文献
773.
774.
Sources of difficulty in deductive reasoning: The THOG task 总被引:2,自引:0,他引:2
David P. O'Brien Ira A. Noveck George M. Davidson Shalom M. Fisch R. Brooke Lea Jason Freitag 《The Quarterly Journal of Experimental Psychology Section A: Human Experimental Psychology》1990,42(2):329-351
The THOG task presents four designs constructed from two shapes and two colours. Subjects are told that the experimenter has written down one of the shapes and one of the colours and are provided the rule that if, and only if, any design has either the shape or the colour, but not both, written down, then it is a THOG. Finally, they are given an exemplar and are asked to classify the remaining designs. Successful solution requires construction of hypotheses, reasoning under each hypothesis, and comparison of the results under each to reach a final conclusion. Few subjects are able to provide adequate responses on the standard version of the task. We present the results of four experiments, with 160 undergraduates each presented with one of eight versions of the task. Experiments 1 and 2 indicate that (1) some subjects think that the properties that are written down are identical to those of the exemplar, although these are not the same subjects who exhibit the modal error pattern, (2) many subjects correctly understand the disjunction of the rule but fail to consider the hypotheses, and (3) poor initial encoding of the problem is not easily corrected. Experiment 3 investigates the sufficiency of the claim of Griggs and Newstead (1982) that appropriate problem solution follows from explicit presentation of all problem information (including use of positive labels for properties that are not written down), and Experiment 4 investigates the necessity of the claim. The results of Experiments 3 and 4 show that presenting positive category labels does increase the frequency of correct solution; however, positive category labels are not necessary for such improvement. Separation of the labels of the THOG rule from those of the exemplar, or informing subjects that only one other design is a THOG, also increases the frequency of successful solution. The results suggest that many people have some fairly sophisticated reasoning skills. but application of these skills is easily discouraged when the features of the task lead to poor initial encoding. 相似文献
775.
Event-Related Potentials were recorded over occipital and parietal scalp from left- and right-handed adults presented with a language and a non-language visual stimulus using a divided field, "oddball" paradigm. The major finding of interest was that the P300 component was larger over the left than the right hemisphere of the right-handers when the language stimulus was presented to the left hemisphere; there were no hemispheric differences for the left-handers, regardless of field of presentation. These results are discussed in the context of developing noninvasive measures to lateralize language function. 相似文献
776.
777.
The present study indicates that some of the inconsistencies in studies of the lateralization of mental rotation may be a consequence of uncontrolled individual differences in the general level of spatial ability. In order to investigate the relation between spatial ability and the lateralization of mental rotation, 48 subjects (24 males and 24 females) were divided into three groups based on their performance on a standardized test of spatial ability. They then performed a lateralized two-dimensional mental rotation task. The results showed the typical mental rotation function in that angle of rotation and reaction time were linearly related. A significant spatial ability by visual field interaction indicated that subjects with low spatial ability had a left field advantage, whereas subjects with medium spatial ability showed no field advantage and subjects with high spatial ability showed a right field advantage. Gender also interacted with visual field, with males showing a left visual superiority and females an insignificant right visual field advantage. A significant three-way interaction of gender, spatial ability, and angle of rotation reflected the fact that low spatial males were more profoundly affected by rotation than the other groups. The results suggest that at least some of the inconsistent findings in studies of lateralization of mental rotation may be accounted for by differences in the level of spatial ability. 相似文献
778.
Locus of information in words and the right visual field effect 总被引:2,自引:0,他引:2
The right visual field (RVF) advantage found for the identification or classification of words has usually been interpreted as evidence for left hemisphere language functions. It has more recently been explained as the result of the fact that the most informative part of the word, presumably the beginning, is in a region of better visual acuity. It is not clear from existing evidence that the beginnings of words are in fact more informative. The present study assessed the locus of information in words by deleting either the initial or terminal one or two letters. Subjects were required to generate a completion. Regardless of whether subjects were scored as correct for generating the original target word (as would be appropriate in a naming study) or for producing any legitimate word (as would be appropriate for a lexical decision study), the results indicated that most words have more information in the initial letters. Nevertheless, there are exceptions to this rule, and some words have more terminal information. Equal numbers of words with more initial information and with more terminal information were selected for two visual field studies in order to assess the effect of the locus of information on visual laterality. In neither a lexical decision study nor a naming study did locus of information affect the commonly observed right visual field superiority. Thus the distribution of information is not likely to be a major confounding variable in laterality studies employing horizontally presented words. 相似文献
779.
Efficacy of behavioral management and patient education on vascular access cleansing compliance in hemodialysis patients 总被引:1,自引:0,他引:1
Compared four treatment conditions to test their ability to enhance compliance with vascular access cleansing (VAC) procedures in a group of 56 hemodialysis patients. The conditions were patient education, behavioral management with monetary incentive, patient education/behavioral management, and attention control. Behavioral observers rated VAC behavior at pretreatment, posttreatment 1-month follow-up, and 1-year follow-up. Knowledge of VAC procedures was also assessed via a questionnaire at pretreatment and posttreatment. Data were analyzed using repeated-measures multivariate analyses of variance. Results indicated that the patients in the education/behavioral, behavioral, and education groups gave significantly more correct answers on our VAC knowledge questionnaires at posttreatment than did patients in the attention control group. Further, patients in the education/behavioral and behavioral groups completed significantly more VAC steps at posttreatment and 1-month follow-up than did patients in the education group and in the attention control group. Differences were not maintained at 1-year follow-up, although more than 50% of the patients were lost to follow-up. Implications of the present findings for behavioral and educational interventions are discussed. 相似文献
780.
Summary In the literature two different views with regard to the time course of activation of recognition units —hypothetical entities that represent identity information —are proposed. Both views are derived from a restricted set of phenomena in visual perception. The first view gets its intuitions from phenomena such as those summarized by Bloch's law; these phenomena show integration or summation of activation over time. This grow-and-grow view assumes that recognition units accumulate activation gradually over times The second view finds its inspiration in phenomena such as Mach-bands and simultaneous contrast; these phenomena show inhibition or steady-state suppression over time. This grow-and-shrink view assumes that the activation levels increase fast initially and then start to decrease.The perception literature strongly suggests that it may be light intensity that determines whether mainly integration (and phenomena such as Bloch's law) or inhibition (and phenomena such as Mach-bands) is obtained. So it is also likely that both information-processing views apply only to a limited range of intensity conditions; the grow-and-grow view to conditions of low-flight intensities, and the grow-and-shrink view to conditions of intermediate-and high-light intensities.It is argued that, to arrive at a complete view, a visual phenomenon that applies to the complete range of light intensities should be taken as a background for generating hypotheses about time courses in visual-information processing. The Broca-Sulzer effect is such a phenomenon. Starting from this phenomenon a simple, synthesizing, information-processing model is derived that is compatible with both the grow-and-grow view and the grow-andshrink view. It is shown that, besides the relevant temporal properties, this model also produces the appropriate spatial properties. 相似文献