Lessons Learned from the Parents Matter! Program

We present a discussion of some of the lessons the investigators learned during the development and implementation phases of the Parents Matter! Program (PMP). Lessons were learned that are relevant to various groups involved in large scale, multi-site, community-based intervention studies: investigators, community leaders, community members, project staff, and participants. Specific lessons learned include: (1) forge collaboration early: (2) maintain communication; (3) clearly delineate policies and procedures; and (4) develop proactive strategies. We also include a list of important questions to consider when contemplating similar projects.     

Cerebellar dentate nuclei lesions reduce motivation in appetitive operant conditioning and open field exploration

Recently identified pathways from the dentate nuclei of the cerebellum to the rostral cerebral cortex via the thalamus suggest a cerebellar role in frontal and prefrontal non-motor functioning. Disturbance of cerebellar morphology and connectivity, particularly involving these cerebellothalamocortical (CTC) projections, has been implicated in motivational and cognitive deficits. The current study explored the effects of CTC disruption on motivation in male Long Evans rats. The results of two experiments demonstrate that electrolytic lesions of the cerebellar dentate nuclei lower breaking points on an operant conditioning progressive ratio schedule and decrease open field exploration compared to sham controls. Changes occurred in the absence of motor impairment, assessed via lever pressing frequency and rotarod performance. Similar elevated plus maze performances between lesioned and sham animals indicated that anxiety did not influence task performance. Our results demonstrate hedonic and purposive motivational reduction and suggest a CTC role in global motivational processes. These implications are discussed in terms of psychiatric disorders such as schizophrenia and autism, in which cerebellar damage and motivational deficits often present concomitantly.     

Personal, Medical, and Healthcare Utilization Among Homeless Veterans Served by Metropolitan and Nonmetropolitan Veteran Facilities

This study assessed differences in personal, medical, and health care utilization characteristics of homeless veterans living in metropolitan versus nonmetropolitan environments. Data were obtained from a Veterans Health Administration (VHA) network sample of homeless veterans. Chi-square tests were used to assess differences in demographics, military history, living situation, medical history, employment status, and health care utilization. Moderator analyses determined whether predictors of health care utilization varied by metropolitan status. Of 3,595 respondents, 60% were residing in metropolitan areas. Age, sex, and marital status were similar between metropolitan and nonmetropolitan homeless. Metropolitan homeless were less likely to receive public financial support or to be employed, to have at least one medical problem, one psychiatric problem, or current alcohol dependency, but more likely to be homeless longer. Of the 52% of the sample who used VHA care in the last 6 months, 53% were metropolitan versus 49% nonmetropolitan (p = .01). Metropolitan status predicted at least one VHA visit within the prior 6 months (OR:1.3, CI:1.1, 1.6). Significant differences occur in the personal, medical, and health care utilization characteristics of homeless veterans in metropolitan versus nonmetropolitan areas.     

Sensitivity and specificity of depression questionnaires in a college-age sample

The authors evaluated the sensitivity and specificity of the Beck Depression Inventory-II (BDI-II; A. T. Beck, R. A. Steer, & G. K. Brown, 1996) and Center for Epidemiological Studies-Depression Scale (CESD; L. S. Radloff, 1977) questionnaires for a college-student sample. Results indicate that the BDI-II and CES-D evidenced satisfactory levels of specificity and positive predictive value for current, past-year, and lifetime depressive disorder ratings on the Diagnostic Interview Schedule-IV (American Psychiatric Association, 1994). Researchers can use the questionnaires as valid initial screens in a two-stage process designed to identify individuals meeting Diagnostic and Statistical Manual of Mental Disorders-IV (American Psychiatic Association) criteria for depressive disorders. However, if the questionnaires are the only method used to select participants, the resulting sample may include a number of false positives.     

Associations of substance use problems with intimate partner violence for at-risk men in long-term relationships

Associations of substance use problems in men--defined as a man's meeting at least 1 criterion of dependence on each of a number of substances by his mid-20s--with their perpetration of intimate partner violence (IPV) were examined in an at-risk community sample of 150 men in long-term relationships from their late adolescence to their late 20s. Men who had a problem with substances other than sedatives (especially cannabis and hallucinogens) committed more IPV than did men without such problems. Most of the men who had a problem with marijuana also had an alcohol problem, which explains why alcohol was found to have only an indirect association with IPV. The failure of previous alcohol-use studies to control for co-occurrence of alcohol and marijuana problems may explain the discrepancy with conclusions from past research that alcohol problems contribute directly to the perpetration of IPV.     

Staying in or moving away from structured activities: Explanations involving parents and peers

Adolescent participation in structured activities, meaning those with adult leaders, regular meetings, and skill-building activities, is related to good adjustment. Participation in unstructured, unsupervised, peer-oriented activities is related to poor adjustment. Structured activity participation is high in early adolescence and then declines, raising the question of why youths leave structured activities. The authors examined explanations involving parents and peers. They used longitudinal data from 861 youths (ages 13-17 years). Results showed that, compared with youths who stayed in structured activities, those who switched to hanging out on the streets were less likely to have peers in structured activities and had less positive feelings about the home context and more negative interactions with parents. In addition, delinquency predicted switching to hanging out in the streets and never joining structured activities in the first place. The results concerning parents support a theoretical explanation of how parents might unintentionally affect youths' leisure choices. Furthermore, the authors found some indications that positive feelings at home might protect youths who switch from structured activities to hanging out on the streets from increases in delinquency.     

Clinical Effectiveness of the LE<Superscript>3</Superscript>AN Program: A Military Healthy Lifestyle Program

For several decades, obesity has been a major health concern within the general population of the United States as well as within the unique military population. Unlike the civilian sector, military service requires individuals to meet weight and body fat standards. In order to assist overweight military personnel return to standards, Tripler Army Medical Center initiated the LE³AN Program. LE³AN is a one-week, day-treatment, cognitive-behavioral weight management program coupled with 12 months of weekly follow-up. Baseline data was collected on 387 consecutive participants. Despite physical fitness training and required standards in each military service, the average BMIs for men and women were in the obese range, with male participants’ BMIs significantly higher than women’s (34.3 vs 31.9, p<.005). One year outcome data was collected from 167 participants, i.e. 43.2% of treatment initiators. Among participants who completed treatment, men maintained a 6.56% loss of their initial weight while women maintained a 7.35% loss. Over a quarter, 26.6%, of those who started the program (but did not complete it) maintained at least a 5% weight loss at one year, while 61.6% of treatment completers maintained 5% weight losses. The opinions expressed in this article reflect the views of the authors and not those of the Department of Defense or the U.S. Army.     

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice

The present study was designed to examine whether life-long exposure to standard or enriched housing affects the ability of estrogen to improve spatial and object memory throughout the lifespan. Three-week-old female mice were maintained in standard or enriched housing up to and through ovariectomy and behavioral testing at 5, 17, or 22 months of age. Spatial memory was tested in the Morris water maze and object memory was tested using an object recognition task. Immediately after training each day, mice were injected intraperitoneally with vehicle or 0.2 mg/kg 17beta-estradiol. Among young females, object recognition was enhanced by estradiol alone, an effect that was reduced by enrichment. In contrast, spatial water maze performance was impaired by estradiol alone, but improved by the combination of both estradiol and enrichment. At middle-age, object recognition was enhanced by estradiol or enrichment alone, and the combination of both treatments. Spatial memory in the water maze was also improved by both treatments at middle-age, but the beneficial effects of estradiol were limited to standard-housed females. Finally, whereas enrichment in aged females significantly enhanced performance in both tasks, estradiol had no effect at this age in either task. In total, the data indicate that life-long enrichment can significantly alter the extent to which estradiol affects memory in mice throughout the lifespan. Importantly, the interaction between these treatments is highly dependent on age and type of memory tested.     

“100% of anything looks good”: The appeal of one hundred percent

People overweight certainty, even when certainty is only an illusion. A vaccine that was described as 100% effective against 70% of disease targets was preferred to one described as 70% effective against 100% of disease targets (Studies 1 and 2). The appeal of 100% extends beyond the probability attribute. In Study 2, participants preferred both of the vaccines above to normatively equivalent vaccines that were less than 100% effective toward fewer than 100% of targets. In Study 3, participants preferred a 100% discount on a cup of coffee every 10 days to other more frequent, but lower amount, discounts. This preference evaporated, however, when savings were framed as points rather than as percentage discounts. We propose that people view 100% as a salient reference point and overweight it in those domains where it cannot be exceeded (e.g., probability, discount); the overweighting is weaker in domains where 100% can be exceeded (e.g., target range, points).