Effect of Interleukin-1beta on Pituitary-Adrenal Responses and Body Weight in Neonatal Rats: Interaction with Maternal Deprivation

The hypothalamic-pituitary-adrenal (HPA) axis of the infant rat is normally hyporesponsive during postnatal days (pnd) four to fourteen. This interval is termed the stress hyporesponsive period (SHRP). The HPA axis, however, does respond to selective stimuli, such as interleukin-1beta (IL-1beta) during this period. Furthermore, maternal deprivation has been shown to alter the system so that it is responsive to mild stimuli. The present studies examined the interaction between 24 h of maternal deprivation and intraperitoneal administration of recombinant human (rh) IL-1beta (4 μg/kg) at 3 ages (i.e., pnd 6, 12, 18) during or after the SHRP. The results demonstrate that maternal deprivation modifies the response of the HPA axis induced by IL-1beta in an age-dependent fashion: 1) a greater response at pnd 6; 2) a quicker response at pnd 12; and 3) a suppressed response pattern at pnd 18. Moreover, these responses across ages differ as a function of maternal contact postinjection: 1) deprivation augments the ACTH and CORT response and maternal contact postinjection further augments this response at pnd 6; 2) deprivation increases the ACTH and CORT response to vehicle and the CORT response to IL-1beta in 12 day-old pups and the mother has a modest inhibitory effect; and 3) at pnd 18 deprivation leads to lower ACTH concentrations, but higher overall CORT levels and maternal contact postinjection effectively suppresses both the ACTH and CORT response to IL-1. These differences in the HPA response do not appear to be due to differences in the immune response. Plasma concentrations of endogenous rat IL-1beta determined 1 and 2 h after injection of rhIL-1beta were not modified by deprivation and were reduced at pnd 18 compared to pnd 6 and 12 in NDEP pups. Finally, IL-1beta reduced food intake, as reflected by a decrease in body weight, in deprived pups at all 3 ages. The findings in the present experiments suggest that there are additional pathways through which IL-1beta can act on the CNS to activate the HPA axis besides direct action at the hypothalamus.     

Deviant Scripturalism and Ritual Satanic Abuse Part Two: Possible Masonic, Mormon, Magick, and Pagan Influences

Having shown in a previous paper the possible Judeo-Christian influences that may exist in ritual satanic abuse, this study compares portions of people's accounts (using interviews and diaries from several alleged survivors), with doctrinal precedents for satanic ritual abuse in deviant interpretations of Masonic, Mormon, Magick, and Pagan traditions.     

Is transcendental idealism coherent?

I argue that transcendental idealism can be understood as a coherent and plausible account of experience. I begin by proposing an interpretation of the claim that we know only appearances that does not imply that the objects of experience are anything other than independently real objects. As I understand it, the claim here is abouthow objects appear to us, and not aboutwhat objects appear to us. After this, I offer a version of a correspondence account of veridical experience, in virtue of which these independent entities can satisfy the contents of our experiences. Specifically, I claim that veridical experience can be construed as a kind of map of reality in itself, and that these independent entities satisfy the contents of our experiences when they are, given the proper method of projection, the objects mapped by those experiences.     

Effects of speech rate on the absolute and relative timing of apraxic and conduction aphasic sentence production

The purpose of this investigation was to provide a constructive replication of the Kent and McNeil (1987, In Phonetic approaches to speech production in aphasia and related disorders. San Diego: College-Hill Press) study of the speech timing characteristics of apraxic and conduction aphasic speakers. Acoustic analysis was used to obtain absolute utterance durations, segment durations, and vowel formant trajectories from utterances produced under control, fast, and slow rate conditions. Segment-to-whole ratios and slope values were calculated. Results support the hypothesis presented by Kent and McNeil (1987) that there is a phonetic-motoric component contributing to the speech patterns of both the apraxic and conduction aphasic speakers sampled. Theories of rate control in normal and disordered speakers are discussed.     

Anxiety management training in the treatment of essential hypertension

The study was conducted to assess the efficacy of Anxiety Management Training as an adjunctive treatment for essential hypertension. Twenty-one patients with essential hypertension, all but one of whom were on antihypertension medication, were randomly assigned either to an Anxiety Management Training condition or a waiting-list control condition. At the time of a posttest assessment session, compared to subjects in the control condition, subjects in the Anxiety Management Training condition manifested a decrease in resting systolic and diastolic blood pressure and a decrease in systolic and diastolic blood pressure following a stressful task. At the time of a follow-up assessment session, subjects in the Anxiety Management Training condition not only manifested good maintenance of reduced blood pressure but also exhibited a further decrease in resting systolic blood pressure and a decrease in systolic blood pressure during the stressful task.     

The type a behavior pattern,sex differences,and cardiovascular response to and recovery from stress

Sixty-one subjects performed a Stroop Color-Word Interference task, a mental arithmetic task (serial subtraction of 7s), and a shock avoidance task (repeating digits backward while expecting to be shocked for mistakes). Systolic and diastolic blood pressure and pulse rate were recorded while subjects anticipated, undertook, and recovered from the shock avoidance task, and undertook and recovered from the Stroop and mental arithmetic tasks. The results revealed that, compared to Type B subjects, Type A subjects manifested higher diastolic blood pressure during the Stroop and shock avoidance tasks and higher pulse rate following the mental arithmetic and shock avoidance tasks. No significant interactions were found between sex and A/B Type. The results are congruent with the notion that greater sympathetic nervous system activity among Type A individuals, both men and women, contributes to greater coronary atherosclerosis and heart disease in this group.     

Differences in encoding for free recall vs. recognition

Three experiments examined effects of test expectancy on memory for relatively unrelated words. In Experiment I, where preliminary recall or recognition practice was given, both recall and recognition were superior when the subjects expected and had practiced for recall. Free study led to better recall and recognition than paced presentation, but did not interact with test expectancy. Experiment II demonstrated that recall was better for subjects expecting a recall vs. a recognition test in the absence of preliminary practice. In Experiment III all subjects practiced both recall and recognition prior to presentation of the critical list. Study time also was varied. With longer study, recall was better when a recall test was expected, with no test expectancy effect on recognition. There were no appreciable expectancy effects with the short study period. Self-reports and other data suggested that the critical encoding differences produced by test expectancy manipulation were quantitative in nature.     

Type a behavior,irritability, and cardiovascular response

Previous research suggests that high levels of hostility may augment the cardiovascular reactivity and risk of coronary heart disease (CHD) associated with Type A behavior. In contrast, other research indicates that the tendency to deny or suppress anger is associated with enhanced cardiovascular reactivity and risk of CHD. To delineate further the combined role of anger processes and Type A behavior in CHD risk, this study examined the interactive effects of Type A behavior and self-reported irritability on cardiovascular response to a challenging mental task. Type A and Type B college students were further classified as either high or low in self-reported irritability. Type A subjects who were low in self-reported irritability evidenced greater cardiovascular reactivity (i.e., systolic blood pressure and pulse rate) than did Type B subjects low in irritability. However, Type A subjects who were high in irritability tended to demonstrate less cardiovascular response than Type B subjects high in irritability. Further, Type A's low in self-reported irritability evidenced greater cardiovascular response than high-irritability Type A's. It is suggested that reduced reporting of irritability by Type A's may reflect suppression or denial, and further that this reduced reporting is associated with enhanced cardiovascular responsivity.     

Anxiety, pain and type of dental procedure

The anxiety, pain expected and pain experienced of patients arriving for their scheduled dental appointments were measured. The amount of pain expected and experienced was found to be related to the type of dental procedure. Highly anxious patients expected more pain than they experienced when they received drilling/extraction type procedures but the discrepancy was small when they were due to receive a check-up. Low-anxiety patients, by contrast, accurately predicted the amount of pain they would experience, whatever the procedure. The results may explain why anxiety about dentistry is slow to extinguish.