Beta-Amyloid Deposition and the Aging Brain

A central issue in cognitive neuroscience of aging research is pinpointing precise neural mechanisms that determine cognitive outcome in late adulthood as well as identifying early markers of less successful cognitive aging. One promising biomarker is beta amyloid (Aβ) deposition. Several new radiotracers have been developed that bind to fibrillar Aβ providing sensitive estimates of amyloid deposition in various brain regions. Aβ imaging has been primarily used to study patients with Alzheimer’s Disease (AD) and individuals with Mild Cognitive Impairment (MCI); however, there is now building data on Aβ deposition in healthy controls that suggest at least 20% and perhaps as much as a third of healthy older adults show significant deposition. Considerable evidence suggests amyloid deposition precedes declines in cognition and may be the initiator in a cascade of events that indirectly leads to age-related cognitive decline. We review studies of Aβ deposition imaging in AD, MCI, and normal adults, its cognitive consequences, and the role of genetic risk and cognitive reserve.     

Leadership and Adolescent Girls: A Qualitative Study of Leadership Development

This research investigated youth leadership experiences of adolescent girls who participated in a comprehensive feminist-based leadership program. This qualitative study utilized a grounded theory approach to understand changes that occurred in 10 female adolescent participants. The words of the participants revealed that initially they viewed leadership in traditional terms and were hesitant to identify themselves as leaders or to see themselves included within their concepts of leadership. Following the program their view of leadership expanded and diversified in a manner that allowed for inclusion of themselves within it. They spoke with greater strength and confidence and felt better positioned and inspired to act as leaders. Participants identified having examples of women leaders, adopting multiple concepts of leadership, and participating in an environment of mutual respect and trust as factors that contributed to their expanded conceptualization.     

Reflective practice framework for TESOL teachers: one teacher’s reflective journey

Just as in the field of general education, scholars within the field of teaching English to speakers of other languages (TESOL) have also struggled to come to a consensus as to how reflective practice should be operationalized with many different approaches suggesting a retrospective approach to questioning about practice. As a result, many of these approaches have led to a type of routinization of reflection. Worried about such routinization of reflection, Farrell developed a more holistic approach to reflective practice that recognizes the spiritual, moral, and emotional aspects of reflection, as well as the usual retrospective questions about practice. This paper outlines a case study of the reflections of one experienced TESOL teacher teaching in South Korea using Farrell’s framework for reflecting on practice that included reflections on his philosophy, principles, theory, practice, and beyond practice. The results revealed three common themes of approachability, art-oriented conceptions, and curiosity that emerged in all aspects of his reflection as uniquely influential parts of a larger whole. Thus, Farrell’s holistic framework for teacher reflection employed in this study provided multiple filters through which these various parts could be viewed.     

A study of syntactic processing in aphasia II: neurological aspects

This paper presents the results of a study of the effects of left hemisphere strokes on syntactically-based comprehension in aphasic patients. We studied 42 patients with aphasia secondary to left hemisphere strokes and 25 control subjects for the ability to assign and interpret three syntactic structures (passives, object extracted relative clauses, and reflexive pronouns) in enactment, sentence-picture matching and grammaticality judgment tasks. We measured accuracy, RT and self-paced listening times in SPM and GJ. We obtained magnetic resonance (MR) and 5-deoxyglucose positron emission tomography (FDG PET) data on 31 patients and 12 controls. The percent of selected regions of interest (ROIs) that was lesioned on MR and the mean normalized PET counts per voxel in ROIs were calculated. In regression analyses, lesion measures in both perisylvian and non-perisylvian ROIs predicted performance. Patients who performed at similar levels behaviorally had lesions of very different sizes, and patients with equivalent lesion sizes varied greatly in their level of performance. The data are consistent with a model in which the neural tissue that is responsible for the operations underlying sentence comprehension and syntactic processing is localized in different neural regions in different individuals.     

TEACHING CHOICE MAKING DURING SOCIAL INTERACTIONS TO STUDENTS WITH PROFOUND MULTIPLE DISABILITIES

We taught 4 students with profound multiple disabilities to use a microswitch communication system to request a change in recreational stimuli during social interactions with nondisabled peers. In Study 1, we conducted a preference assessment across a range of stimuli for each student. The most and least preferred stimuli were incorporated into microswitch communication system training in Study 2. During the second study, 3 of the 4 students (a) learned to use the microswitch communication system to control stimulus presentation, (b) more clearly differentiated their time among stimuli, and (c) increased their level of general alertness. Study 3 extended the use of the microswitch communication system to social interactions with nondisabled peers. Two students were more engaged in interactions when they chose when to change stimuli; 1 student was more alert when a peer chose when to change activities; a 4th student showed an undifferentiated pattern. The outcomes of the investigation are discussed in terms of the effects of controlling stimulus presentation on the behavior of students with profound multiple disabilities and the stability of preference hierarchies over time.     

Timing precision in circle drawing does not depend on spatial precision of the timing target

The authors manipulated the width of a timing target in continuous circle drawing to determine whether a more stringent spatial-timing criterion would produce an increase in participants' (N = 30) temporal variability. They also examined the effect of the computational method of determining cycle duration. There was no effect of spatial precision on temporal variability in circle drawing, and tapping and circle drawing were found to use the same criterion. Those findings lend strong support to the earlier view of R. B. Ivry, R. M. Spencer, H. N. Zelaznik, and J. Diedrichsen (2002), who argued that continuous tasks such as circle drawing are timed differently from discrete-like tasks such as tapping. Therefore, the results of the present study provide support for the event and emergent timing frameworks.     

The Effect of Warnings to Timeout on Child Compliance to Parental Instructions

ABSTRACT

One common component of behavioral parent training packages is the use of a warning prior to implementation of a timeout following noncompliance to parental instructions. The primary purpose of this research was to evaluate the effects of warnings on compliance. An alternating treatments design was used to evaluate compliance to warned versus unwarned timeouts with three typically developing children. All participants showed a significant increase in compliance upon implementation of the timeout package, either with or without a warning. However, compliance decreased over time in the Warning condition for two participants and increased in variability for a third. All participants had more timeouts in the No Warning condition. Results also showed preliminary evidence for parental preference of Warned timeouts. Implications are discussed.