Ethical Issues in HIV/STD Prevention Research With High Risk Youth: Providing Help,Preserving Validity

Many preventive intervention studies with adolescents address high-risk behaviors such as drug and alcohol use, and unprotected sex. Randomized controlled trials (RCT) are the gold standard methodology used to test the effectiveness of these behavioral interventions. Interventions outside the rigidly described protocol are prohibited. However, there are ethical challenges to implementing inflexible intervention protocols, especially when the target population is young, experiences many stressful events, and lives in a resource-poor environment. Teens who are at high risk for substance use or sexual risk behaviors tend to be at risk for other problems such as exposure to violence, sexual and physical abuse, depression, and homelessness. How should investigators deal with the psychological and social needs of teenagers in prevention programs in an ethically appropriate way and at the same time preserve the validity of RCT results? We have identified program characteristics, participant characteristics, interaction with parents, and problems with adolescents not in the study as sources of ethical dilemmas in RCT with at-risk adolescents. As a result of our experience, we recommend that every behavioral intervention study develop an ethics protocol, which should include rules for providing help to participants, has contact information for experts to provide guidance, and an emergency procedure for dealing with life threatening situations. In addition, studies should have a resource manual, train research staff in these ethical issues, and work with a data safety and monitoring board or ethics committee.     

Empathy,Tact and the Freedom to be Natural

This paper explores the concepts of tact and empathy in the context of the Freud–Ferenczi correspondence around Ferenczi’s “The Elasticity of Psycho-Analytic Technique” paper. It goes on to explore the problems that they encounter in the neighborhood of reconciling science and subjectivity, in relation to the work on personal knowledge of the Hungarian philosopher Michael Polanyi and concludes with some implications for psychoanalytic training.     

Variable solutions to the same problem: aberrant practice effects in object naming by three aphasic patients

Although deficits in confrontation naming are a common consequence of damage to the language areas of the left cerebral hemisphere, some patients with aphasia show relatively good naming ability. We measured effects of repeated practice on naming latencies for a set of pictured objects by three aphasic patients with near-normal naming ability and by neurologically intact young and older adults. While the non-injured participants showed a systematic reduction in overall mean latencies and reduced trial-to-trial latency variability, the aphasic patients did not. Examination of the latency distributions suggests that successful naming by aphasic patients may come about by different underlying operations.     

Distinctive features hold a privileged status in the computation of word meaning: Implications for theories of semantic memory

The authors present data from 2 feature verification experiments designed to determine whether distinctive features have a privileged status in the computation of word meaning. They use an attractor-based connectionist model of semantic memory to derive predictions for the experiments. Contrary to central predictions of the conceptual structure account, but consistent with their own model, the authors present empirical evidence that distinctive features of both living and nonliving things do indeed have a privileged role in the computation of word meaning. The authors explain the mechanism through which these effects are produced in their model by presenting an analysis of the weight structure developed in the network during training.     

Priming race in biracial observers affects visual search for Black and White faces

We examined whether or not priming racial identity would influence Black-White biracial individuals' ability to visually search for White and Black faces. Black, White, and biracial participants performed a visual search task in which the targets were Black or White faces. Before the task, the biracial participants were primed with either their Black or their White racial identity. All participant groups detected Black faces faster than White faces. Critically, the results also showed a racial-prime effect in biracial individuals: The magnitude of the search asymmetry was significantly different for those primed with their White identity and those primed with their Black identity. These findings suggest that top-down factors such as one's racial identity can influence mechanisms underlying the visual search for faces of different races.     

Risk Reduction Behaviors and Provider Communication Following Genetic Counseling and BRCA1 Mutation Testing in an African American Kindred

Little is known about the impact of cancer genetic counseling and testing on health behaviors in racial and ethnic subgroups. This prospective observational study examined use of risk reduction strategies following BRCA1 counseling and testing. Participants were female members of an African American kindred who received genetic education, counseling and testing (n = 40) and completed a 1-year follow-up interview. Mutation carriers were more likely to opt for breast (100%, 7/7) and ovarian (25%; 1 of 4) cancer surveillance than prophylactic surgery. Following genetic counseling, 71% (5/7) of the BRCA1 carriers who opted for surveillance reported having a mammogram within the year following receipt of their genetic test results. Ovarian cancer screening among mutation carriers increased from 0% at baseline to 25% (one of four) at 1 year. Compared to noncarriers (23%, 7/30), carriers (70%, 7/10) were more likely to discuss their BRCA1 test results with their primary health care providers. Surveillance for breast cancer was preferred to prophylactic surgery and chemoprevention as a way to reduce risk for these cancers. Our data indicate that patient-provider communication about BRCA1 test results is suboptimal.     

Honeybees (Apis mellifera) holding on to memories: response competition causes retroactive interference effects

Five experiments on honeybees examined how the learning of a second task interferes with what was previously learned. Free flying bees were tested for landmark-based memory in variations on a paradigm of retroactive interference. Bees first learned Task 1, were tested on Task 1 (Test 1), then learned Task 2, and were tested again on Task 1 (Test 2). A 60-min delay (waiting in a box) before Test 2 caused no performance decrements. If the two tasks had conflicting response requirements, (e.g., target right of a green landmark in Task 1 and left of a blue landmark in Task 2), then a strong decrement on Test 2 was found (retroactive interference effect). When response competition was minimised during training or testing, however, the decrement on Test 2 was small or nonexistent. The results implicate response competition as a major contributor to the retroactive interference effect. The honeybee seems to hold on to memories; new memories do not wipe out old ones.